Paper · 33262135

Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer.

Väyrynen SA and 28 others. Clin Cancer Res, 2021. Cited by 136 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer. Papers, record 33262135. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33262135

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Composition, Spatial Characteristics, and Prognostic Significance of Myeloid Cell Infiltration in Pancreatic Cancer.; PubMed
Journal: Clin Cancer Res; PubMed
Year: 2021; PubMed
Publication types: Journal Article, Multicenter Study, Observational Study, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/33262135/; PubMed
DOI: https://doi.org/10.1158/1078-0432.ccr-20-3141; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8345232/; PubMed
The journal: https://conductscience.org/library/journal-index/9502500; PubMed
Citations, by iCite: 136; iCite
Relative citation ratio, by iCite: 6.31; iCite
Revised in PubMed: 2024-04-03; PubMed

Authors29

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	ORCID iD
1	Väyrynen SA	Sara A	https://orcid.org/0000-0002-8683-2996
2	Zhang J	Jinming
3	Yuan C	Chen	https://orcid.org/0000-0002-0708-9648
4	Väyrynen JP	Juha P	https://orcid.org/0000-0002-8683-2996
5	Dias Costa A	Andressa
6	Williams H	Hannah	https://orcid.org/0000-0003-0434-3900
7	Morales-Oyarvide V	Vicente
8	Lau MC	Mai Chan
9	Rubinson DA	Douglas A	https://orcid.org/0000-0002-5337-5231
10	Dunne RF	Richard F

1 to 10 of 29Source PubMed

See all 29 authors

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Carcinoma, Pancreatic Ductal	Major topic
Myeloid Cells	Major topic
Neoplasm Recurrence, Local	Major topic
Pancreatic Neoplasms	Major topic
Tumor Microenvironment	Major topic
Aged
Cohort Studies
Disease-Free Survival
Female
Humans
Male
Middle Aged
Pancreas
Pancreatectomy
Prognosis
Retrospective Studies

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
U01 CA224146	NCI NIH HHS	United States	U01CA224146	PubMed and NIH	NIH RePORTER
R35 CA197735	NCI NIH HHS	United States	R35CA197735	PubMed and NIH	NIH RePORTER
U01 CA210171	NCI NIH HHS	United States	U01CA210171	PubMed and NIH	NIH RePORTER
K08 CA218420	NCI NIH HHS	United States	K08CA218420	PubMed and NIH	NIH RePORTER
P50 CA127003	NCI NIH HHS	United States	P50CA127003	PubMed and NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References53

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	31,705,130	From state-of-the-art treatments to novel therapies for advanced-stage pancreatic cancer.	Nat Rev Clin Oncol	2020	https://conductscience.org/library/papers/31705130	PubMed
2	30,620,402	Cancer statistics, 2019.	CA Cancer J Clin	2019	https://conductscience.org/library/papers/30620402	PubMed
3	27,813,830	Macrophage Polarization.	Annu Rev Physiol	2017	https://conductscience.org/library/papers/27813830	PubMed
4	24,458,546	Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesis.	Int J Cancer	2014	https://conductscience.org/library/papers/24458546	PubMed
5	32,843,682	Differential association of CD68+ and CD163+ macrophages with macrophage enzymes, whole tumour gene expression and overall survival in advanced melanoma.	Br J Cancer	2020	https://conductscience.org/library/papers/32843682	PubMed
6	24,797,069	Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinoma.	PLoS One	2014	https://conductscience.org/library/papers/24797069	PubMed
7	30,575,490	FOLFIRINOX or Gemcitabine as Adjuvant Therapy for Pancreatic Cancer.	N Engl J Med	2018	https://conductscience.org/library/papers/30575490	PubMed
8	35,359,965	A Comprehensive Atlas of Immunological Differences Between Humans, Mice, and Non-Human Primates.	Front Immunol	2022	https://conductscience.org/library/papers/35359965	PubMed
9	32,334,338	The prognostic value of tumour-infiltrating lymphocytes in pancreatic cancer: a systematic review and meta-analysis.	Eur J Cancer	2020	https://conductscience.org/library/papers/32334338	PubMed
10	25,669,968	Accumulation of FOXP3+T-cells in the tumor microenvironment is associated with an epithelial-mesenchymal-transition-type tumor budding phenotype and is an independent prognostic factor in surgically resected pancreatic ductal adenocarcinoma.	Oncotarget	2015	https://conductscience.org/library/papers/25669968	PubMed

1 to 10 of 53

See all 53 references

Cited by108

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 136 citations.

PMID	Title	Journal	Year	In Papers	Source
42,921,155	Autonomous AI research agents in pancreatic ductal adenocarcinoma immunology: from multimodal evidence to experimental validation.	Front Immunol	2026	https://conductscience.org/library/papers/42921155	PubMed
42,779,702	Conserved Metastatic Cell States and Spatial Immune Microenvironment Remodeling Define Pancreatic Cancer Liver Metastases.	bioRxiv	2026	https://conductscience.org/library/papers/42779702	PubMed
42,643,613	Rethinking PDAC: from immunological silence to therapeutic opportunity.	Front Immunol	2026	https://conductscience.org/library/papers/42643613	PubMed
42,550,364	Local Recurrence After Pancreatic Cancer Resection: A Multidisciplinary Review of Risk Factors and Potential Causes, Diagnostic Innovations, Emerging Therapeutic Frontiers, and Prevention Strategies.	Curr Treat Options Oncol	2026	https://conductscience.org/library/papers/42550364	PubMed
42,547,816	Spatially resolved tissue architecture and computational pathology in pancreatic cancer.	Exp Mol Med	2026	https://conductscience.org/library/papers/42547816	PubMed
42,456,051	Spatial Configuration of Pancreatic Cancer Is Associated with Disease Recurrence after Neoadjuvant Therapy and Curative-Intent Resection.	Clin Cancer Res	2026	https://conductscience.org/library/papers/42456051	PubMed
42,417,469	Impact of vitamin D on the colon cancer immune microenvironment: results of a randomized clinical trial of preoperative vitamin D supplementation in patients with stage I-III colon cancer.	Cancer Discov	2026	https://conductscience.org/library/papers/42417469	PubMed
42,377,389	Multinucleated Giant Cells in Human Pancreatic Cancer Are a Distinct Macrophage Population Undergoing a DNA Damage Response and Associated with an Aggressive Tumor Microenvironment.	Cancer Immunol Res	2026	https://conductscience.org/library/papers/42377389	PubMed
42,233,099	Targeting tumor-associated macrophages in pancreatic cancer.	ILIVER	2026	https://conductscience.org/library/papers/42233099	PubMed
42,224,953	Advances in deciphering intratumoral versus peritumoral heterogeneity of infiltrating lymphocytes in pancreatic cancer: a spatial perspective.	Transl Oncol	2026	https://conductscience.org/library/papers/42224953	PubMed

1 to 10 of 108

See all 108 cited by

Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ARG1	383	PubTator's text mining	https://conductscience.org/library/genes/383	NCBI Gene
CD14	929	PubTator's text mining	https://conductscience.org/library/genes/929	NCBI Gene
CD163	9,332	PubTator's text mining	https://conductscience.org/library/genes/9332	NCBI Gene
CD33	945	PubTator's text mining	https://conductscience.org/library/genes/945	NCBI Gene
CD68	968	PubTator's text mining	https://conductscience.org/library/genes/968	NCBI Gene
CD86	942	PubTator's text mining	https://conductscience.org/library/genes/942	NCBI Gene
CDKN2A	1,029	PubTator's text mining	https://conductscience.org/library/genes/1029	NCBI Gene
FUT4	2,526	PubTator's text mining	https://conductscience.org/library/genes/2526	NCBI Gene
IRF5	3,663	PubTator's text mining	https://conductscience.org/library/genes/3663	NCBI Gene
KRAS	3,845	PubTator's text mining	https://conductscience.org/library/genes/3845	NCBI Gene

1 to 10 of 13

See all 13 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/33262135

GET https://conductscience.org/api/papers/v1/33262135/authors?page=2

API reference For AI assistants