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Paper · 33369095

Xenopus leads the way: Frogs as a pioneering model to understand the human brain.

Exner CRT and 1 other. Genesis, 2021. Cited by 49 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Xenopus leads the way: Frogs as a pioneering model to understand the human brain. Papers, record 33369095. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33369095

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Xenopus leads the way: Frogs as a pioneering model to understand the human brain.
PubMed
Journal
Genesis
PubMed
Year
2021
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Review
PubMed
Citations, by iCite
49
iCite
Relative citation ratio, by iCite
3.11
iCite
Revised in PubMed
2025-08-16
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Exner CRTCameron R T
2Willsey HRHelen Rankinhttps://orcid.org/0000-0001-8404-3291

Source PubMed

Topics5

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
BrainMajor topic
Disease Models, AnimalMajor topic
NeurogenesisMajor topic
Xenopus laevisMajor topic
Animals

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
U01 MH115747NIMH NIH HHSUnited StatesU01MH115747PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References277

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
19,043,084The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis.Development1997https://conductscience.org/library/papers/9043084PubMed
230,545,852Genome-wide de novo risk score implicates promoter variation in autism spectrum disorder.Science2018https://conductscience.org/library/papers/30545852PubMed
332,200,077Lhx2/9 and Etv1 Transcription Factors have Complementary roles in Regulating the Expression of Guidance Genes slit1 and sema3a.Neuroscience2020https://conductscience.org/library/papers/32200077PubMed
419,763,105Evolution of the neocortex: a perspective from developmental biology.Nat Rev Neurosci2009https://conductscience.org/library/papers/19763105PubMed
527,503,008Fragile X mental retardation protein knockdown in the developing Xenopus tadpole optic tectum results in enhanced feedforward inhibition and behavioral deficits.Neural Dev2016https://conductscience.org/library/papers/27503008PubMed
611,715,053Cutting, pasting and painting: experimental embryology and neural development.Nat Rev Neurosci2001https://conductscience.org/library/papers/11715053PubMed
727,314,579Single Cell Proteomics Using Frog (Xenopus laevis) Blastomeres Isolated from Early Stage Embryos, Which Form a Geometric Progression in Protein Content.Anal Chem2016https://conductscience.org/library/papers/27314579PubMed
830,151,756Generation and Care of Xenopus laevis and Xenopus tropicalis Embryos.Methods Mol Biol2018https://conductscience.org/library/papers/30151756PubMed
911,044,411The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning.Development2000https://conductscience.org/library/papers/11044411PubMed
1031,417,417Xenopus: Driving the Discovery of Novel Genes in Patient Disease and Their Underlying Pathological Mechanisms Relevant for Organogenesis.Front Physiol2019https://conductscience.org/library/papers/31417417PubMed

1 to 10 of 277

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Cited by32

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 49 citations.

PMIDTitleJournalYearIn PapersSource
42,898,804Matching developmental timelines of fish, frog, mouse and human brains.Anim Cells Syst (Seoul)2026https://conductscience.org/library/papers/42898804PubMed
42,394,964Assessing circuit function in the developing Xenopus tadpole: a survey of the behavioral toolkit and underlying neural substrates.Front Behav Neurosci2026https://conductscience.org/library/papers/42394964PubMed
42,340,257Signalling through RXRβ and its agonist, bexarotene, promotes neuron formation in Xenopus laevis embryos.Biol Open2026https://conductscience.org/library/papers/42340257PubMed
41,710,520New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project.Front Toxicol2026https://conductscience.org/library/papers/41710520PubMed
41,671,085Ploidy and neuron size impact nervous system development and function in Xenopus.Cell Rep2026https://conductscience.org/library/papers/41671085PubMed
41,142,358Label-free photoacoustic imaging of glassfrog development.Photoacoustics2025https://conductscience.org/library/papers/41142358PubMed
40,756,283Fluoxetine exposure alters behavior and morphology of Xenopus laevis tadpoles.MicroPubl Biol2025https://conductscience.org/library/papers/40756283PubMed
40,595,330AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models.Commun Med (Lond)2025https://conductscience.org/library/papers/40595330PubMed
40,505,942The role of Goldilocks protein kinase DYRK1A in embryonic development.Dev Biol2025https://conductscience.org/library/papers/40505942PubMed
40,138,183A Blueprint for Translational Precision Medicine in Autism Spectrum Disorder and Related Neurogenetic Syndromes.J Child Adolesc Psychopharmacol2025https://conductscience.org/library/papers/40138183PubMed

1 to 10 of 32

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
DLX21,746PubTator's text mininghttps://conductscience.org/library/genes/1746NCBI Gene
DLX51,749PubTator's text mininghttps://conductscience.org/library/genes/1749NCBI Gene
EMX12,016PubTator's text mininghttps://conductscience.org/library/genes/2016NCBI Gene
EMX22,018PubTator's text mininghttps://conductscience.org/library/genes/2018NCBI Gene
EOMES8,320PubTator's text mininghttps://conductscience.org/library/genes/8320NCBI Gene
FOXG12,290PubTator's text mininghttps://conductscience.org/library/genes/2290NCBI Gene
ISL13,670PubTator's text mininghttps://conductscience.org/library/genes/3670NCBI Gene
LHX29,355PubTator's text mininghttps://conductscience.org/library/genes/9355NCBI Gene
NEUROD14,760PubTator's text mininghttps://conductscience.org/library/genes/4760NCBI Gene

1 to 10 of 16

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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