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Paper · 35487993

Life of double minutes: generation, maintenance, and elimination.

Ilić M and 3 others. Chromosoma, 2022. Cited by 25 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Life of double minutes: generation, maintenance, and elimination. Papers, record 35487993. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35487993

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Life of double minutes: generation, maintenance, and elimination.
PubMed
Journal
Chromosoma
PubMed
Year
2022
PubMed
Publication types
Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
25
iCite
Relative citation ratio, by iCite
1.46
iCite
Revised in PubMed
2024-09-04
PubMed

Authors4

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Ilić MMilahttps://orcid.org/0000-0003-4664-9393
2Zaalberg ICIrene Chttps://orcid.org/0000-0001-5535-2853
3Raaijmakers JAJonne Ahttps://orcid.org/0000-0003-1759-8347
4Medema RHRené Hhttps://orcid.org/0000-0002-6754-0381

Source PubMed

Topics6

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Gene AmplificationMajor topic
NeoplasmsMajor topic
Chromosome Aberrations
DNA
Humans
Oncogenes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References132

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
11,611,154Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.Mol Biol Cell1992https://conductscience.org/library/papers/1611154PubMed
22,189,894Double minutes arise from circular extrachromosomal DNA intermediates which integrate into chromosomal sites in human HL-60 leukemia cells.J Clin Invest1990https://conductscience.org/library/papers/2189894PubMed
325,537,274Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells.J Med Genet2015https://conductscience.org/library/papers/25537274PubMed
420,056,677Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci.Hum Mol Genet2010https://conductscience.org/library/papers/20056677PubMed
531,569,279Double-strand breakage in the extrachromosomal double minutes triggers their aggregation in the nucleus, micronucleation, and morphological transformation.Genes Chromosomes Cancer2020https://conductscience.org/library/papers/31569279PubMed
626,687,355Chromothripsis and Kataegis Induced by Telomere Crisis.Cell2015https://conductscience.org/library/papers/26687355PubMed
730,872,802Extrachromosomal oncogene amplification in tumour pathogenesis and evolution.Nat Rev Cancer2019https://conductscience.org/library/papers/30872802PubMed
812,897,142Pathways of DNA double-strand break repair during the mammalian cell cycle.Mol Cell Biol2003https://conductscience.org/library/papers/12897142PubMed
91,628,626Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification.EMBO J1992https://conductscience.org/library/papers/1628626PubMed
109,722,943CpG islands and double-minute chromosomes.Genomics1998https://conductscience.org/library/papers/9722943PubMed

1 to 10 of 132

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Cited by18

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 25 citations.

PMIDTitleJournalYearIn PapersSource
42,826,715An epigenetic program dictates MYC amplification dynamics that promote transient, extrachromosomal, and inherited genomic events.Mol Cell2026https://conductscience.org/library/papers/42826715PubMed
42,245,683Gene amplification in the premalignant stages of non-small cell lung cancer development.Front Oncol2026https://conductscience.org/library/papers/42245683PubMed
41,982,344Acute Myeloid Leukemia, Myelodysplasia-Related (AML-MR), With del(5q) and Double Minutes Containing Chromosomal Segment 11q24 Leading to Amplification and Expression of FLI1.Case Rep Hematol2026https://conductscience.org/library/papers/41982344PubMed
41,811,450BRCA1-A and LIG4 complexes mediate ecDNA biogenesis and cancer drug resistance.Proc Natl Acad Sci U S A2026https://conductscience.org/library/papers/41811450PubMed
41,727,087Evolution of oncogene amplification across 86,000 cancer cell genomes.bioRxiv2026https://conductscience.org/library/papers/41727087PubMed
41,482,934The newfound relationship between extrachromosomal DNAs and excised signal circles.FEBS Lett2026https://conductscience.org/library/papers/41482934PubMed
41,415,205R-loops as a trigger for intra- and extrachromosomal DNA amplification in cancer.Front Cell Dev Biol2025https://conductscience.org/library/papers/41415205PubMed
41,278,658Genetic elements promote retention of extrachromosomal DNA in cancer cells.bioRxiv2025https://conductscience.org/library/papers/41278658PubMed
41,261,124Genetic elements promote retention of extrachromosomal DNA in cancer cells.Nature2026https://conductscience.org/library/papers/41261124PubMed
40,744,497ecDNA replication is disorganized and vulnerable to replication stress.Nucleic Acids Res2025https://conductscience.org/library/papers/40744497PubMed

1 to 10 of 18

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Genes11

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRD423,476PubTator's text mininghttps://conductscience.org/library/genes/23476NCBI Gene
CGAS115,004PubTator's text mininghttps://conductscience.org/library/genes/115004NCBI Gene
DHFR1,719PubTator's text mininghttps://conductscience.org/library/genes/1719NCBI Gene
DNER92,737PubTator's text mininghttps://conductscience.org/library/genes/92737NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
HSR338,386PubTator's text mininghttps://conductscience.org/library/genes/338386NCBI Gene
MDM24,193PubTator's text mininghttps://conductscience.org/library/genes/4193NCBI Gene
MYC4,609PubTator's text mininghttps://conductscience.org/library/genes/4609NCBI Gene
PRKDC5,591PubTator's text mininghttps://conductscience.org/library/genes/5591NCBI Gene

1 to 10 of 11

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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