Paper · 35637317
Phenotypic drug discovery: recent successes, lessons learned and new directions.
Vincent F and 5 others. Nat Rev Drug Discov, 2022. Cited by 238 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Phenotypic drug discovery: recent successes, lessons learned and new directions. Papers, record 35637317. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35637317
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics2
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Drug Discovery | Major topic |
| Humans |
Source PubMed
Grants4
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| P01 HL141084 | NHLBI NIH HHS | United States | P01HL141084 | PubMed | NIH RePORTER |
| R01 HL130840 | NHLBI NIH HHS | United States | R01HL130840 | PubMed | NIH RePORTER |
| R01 HL138539 | NHLBI NIH HHS | United States | R01HL138539 | PubMed | NIH RePORTER |
| R01 HL152055 | NHLBI NIH HHS | United States | R01HL152055 | PubMed | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections1
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
| Kind | PMID | Title | In Papers |
|---|---|---|---|
| Erratum in | 35,688,887 | Publisher Correction: Phenotypic drug discovery: recent successes, lessons learned and new directions. | https://conductscience.org/library/papers/35688887 |
Source PubMed
References213
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 24,749,835 | Discovery of daclatasvir, a pan-genotypic hepatitis C virus NS5A replication complex inhibitor with potent clinical effect. | J Med Chem | 2014 | https://conductscience.org/library/papers/24749835 | PubMed |
| 2 | 31,846,577 | Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis. | J Med Chem | 2020 | https://conductscience.org/library/papers/31846577 | PubMed |
| 3 | 30,840,449 | Accurate Prediction of Biological Assays with High-Throughput Microscopy Images and Convolutional Networks. | J Chem Inf Model | 2019 | https://conductscience.org/library/papers/30840449 | PubMed |
| 4 | 27,560,178 | Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes. | Nat Protoc | 2016 | https://conductscience.org/library/papers/27560178 | PubMed |
| 5 | 33,257,889 | 'It will change everything': DeepMind's AI makes gigantic leap in solving protein structures. | Nature | 2020 | https://conductscience.org/library/papers/33257889 | PubMed |
| 6 | 24,429,096 | A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect. | Lancet Respir Med | 2013 | https://conductscience.org/library/papers/24429096 | PubMed |
| 7 | 10,598,554 | Enzyme inhibition, polyglutamation, and the effect of LY231514 (MTA) on purine biosynthesis. | Semin Oncol | 1999 | https://conductscience.org/library/papers/10598554 | PubMed |
| 8 | 32,054,125 | Cyclin-Dependent Kinase 5 Inhibitor Butyrolactone I Elicits a Partial Agonist Activity of Peroxisome Proliferator-Activated Receptor γ. | Biomolecules | 2020 | https://conductscience.org/library/papers/32054125 | PubMed |
| 9 | 29,718,665 | Emerging Approaches for the Identification of Protein Targets of Small Molecules - A Practitioners' Perspective. | J Med Chem | 2018 | https://conductscience.org/library/papers/29718665 | PubMed |
| 10 | 32,294,346 | A Non-D2-Receptor-Binding Drug for the Treatment of Schizophrenia. | N Engl J Med | 2020 | https://conductscience.org/library/papers/32294346 | PubMed |
1 to 10 of 213
See all 213 referencesCited by159
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 238 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,973,959 | SCOPE-based target and pathway enrichment identifies the histamine H1 receptor as a regulator of exodosis. | Front Pharmacol | 2026 | https://conductscience.org/library/papers/42973959 | PubMed |
| 42,959,982 | 6‑Chloropyridinyl Benzoate Fragments as Selective Anti-Melanoma Scaffolds Triggering ROS-Mediated Mitochondrial Apoptosis. | ACS Omega | 2026 | https://conductscience.org/library/papers/42959982 | PubMed |
| 42,943,318 | Antiviral Agents, 2024. | Pharmaceuticals (Basel) | 2026 | https://conductscience.org/library/papers/42943318 | PubMed |
| 42,928,229 | In vitro bioactivity profile-driven discovery of drug synergies in hepatocellular carcinoma. | J Transl Med | 2026 | https://conductscience.org/library/papers/42928229 | PubMed |
| 42,907,469 | High-content morphological profiling by Cell Painting in 3D spheroids. | Nat Commun | 2026 | https://conductscience.org/library/papers/42907469 | PubMed |
| 42,901,891 | Learning chemical-induced gene expression perturbations with WAVE. | Nat Commun | 2026 | https://conductscience.org/library/papers/42901891 | PubMed |
| 42,890,046 | DEG2MOL: Conditional Latent Flow Matching for Transcriptome-Guided de novo Drug Design. | ACS Omega | 2026 | https://conductscience.org/library/papers/42890046 | PubMed |
| 42,870,030 | A selective NVL inhibitor suppresses tumor growth by targeting ribosome biogenesis. | Nat Chem Biol | 2026 | https://conductscience.org/library/papers/42870030 | PubMed |
| 42,856,504 | High-Throughput Screening Identifies Novel Antileishmanial Scaffolds and Reveals Cross-Species Activity of Structurally Diverse Compounds. | Res Sq | 2026 | https://conductscience.org/library/papers/42856504 | PubMed |
| 42,819,352 | SpotOn: A Tool to Enhance Echo Acoustic Standard Deposition for Quantitative Mass Spectrometry Imaging. | Chem Biomed Imaging | 2026 | https://conductscience.org/library/papers/42819352 | PubMed |
1 to 10 of 159
See all 159 cited byGenes18
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ABL1 | 25 | PubTator's text mining | https://conductscience.org/library/genes/25 | NCBI Gene |
| ADRB2 | 154 | PubTator's text mining | https://conductscience.org/library/genes/154 | NCBI Gene |
| AHR | 196 | PubTator's text mining | https://conductscience.org/library/genes/196 | NCBI Gene |
| CFTR | 1,080 | PubTator's text mining | https://conductscience.org/library/genes/1080 | NCBI Gene |
| CRBN | 51,185 | PubTator's text mining | https://conductscience.org/library/genes/51185 | NCBI Gene |
| DHODH | 1,723 | PubTator's text mining | https://conductscience.org/library/genes/1723 | NCBI Gene |
| DNER | 92,737 | PubTator's text mining | https://conductscience.org/library/genes/92737 | NCBI Gene |
| IKZF1 | 10,320 | PubTator's text mining | https://conductscience.org/library/genes/10320 | NCBI Gene |
| IKZF3 | 22,806 | PubTator's text mining | https://conductscience.org/library/genes/22806 | NCBI Gene |
| KIT | 3,815 | PubTator's text mining | https://conductscience.org/library/genes/3815 | NCBI Gene |
1 to 10 of 18
See all 18 genesDrugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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