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Paper · 36070681

Methionine metabolism controls the B cell EBV epigenome and viral latency.

Guo R and 9 others. Cell Metab, 2022. Cited by 69 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Methionine metabolism controls the B cell EBV epigenome and viral latency. Papers, record 36070681. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36070681

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Methionine metabolism controls the B cell EBV epigenome and viral latency.
PubMed
Journal
Cell Metab
PubMed
Year
2022
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
69
iCite
Relative citation ratio, by iCite
4.91
iCite
Revised in PubMed
2026-07-28
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Guo RRui
2Liang JHJin Hua
3Zhang YYuchen
4Lutchenkov MMichael
5Li ZZhixuan
6Wang YYin
7Trujillo-Alonso VVicenta
8Puri RRishi
9Giulino-Roth LLisa
10Gewurz BEBenjamin E

Source PubMed

Topics9

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Epstein-Barr Virus InfectionsMajor topic
Herpesvirus 4, HumanMajor topic
Animals
Epigenesis, Genetic
Epigenome
Humans
Methionine
Mice
Virus Latency

Source PubMed

Grants5

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 AI164709NIAID NIH HHSUnited StatesR01AI164709PubMed and NIHNIH RePORTER
R00 DE031016NIDCR NIH HHSUnited StatesK99DE031016PubMed and NIHNIH RePORTER
K99 DE031016NIDCR NIH HHSUnited StatesK99DE031016PubMed and NIHNIH RePORTER
R01 CA228700NCI NIH HHSUnited StatesR01CA228700PubMed and NIHNIH RePORTER
R01 AI137337NIAID NIH HHSUnited StatesR01AI137337PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in36,070,678Methionine restriction forces Epstein-Barr virus out of latency.https://conductscience.org/library/papers/36070678

Source PubMed

References93

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
125,159,142The NF-κB genomic landscape in lymphoblastoid B cells.Cell Rep2014https://conductscience.org/library/papers/25159142PubMed
29,525,618Specific methylation patterns in two control regions of Epstein-Barr virus latency: the LMP-1-coding upstream regulatory region and an origin of DNA replication (oriP).J Virol1998https://conductscience.org/library/papers/9525618PubMed
331,367,041Dietary methionine influences therapy in mouse cancer models and alters human metabolism.Nature2019https://conductscience.org/library/papers/31367041PubMed
420,181,711The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.J Virol2010https://conductscience.org/library/papers/20181711PubMed
527,641,100One-Carbon Metabolism in Health and Disease.Cell Metab2017https://conductscience.org/library/papers/27641100PubMed
635,073,561Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM.Nature2022https://conductscience.org/library/papers/35073561PubMed
71,849,678Early events in Epstein-Barr virus infection of human B lymphocytes.Virology1991https://conductscience.org/library/papers/1849678PubMed
831,341,086Epstein-Barr virus reprograms human B lymphocytes immediately in the prelatent phase of infection.Proc Natl Acad Sci U S A2019https://conductscience.org/library/papers/31341086PubMed
929,813,138Continuous DNA replication is required for late gene transcription and maintenance of replication compartments in gammaherpesviruses.PLoS Pathog2018https://conductscience.org/library/papers/29813138PubMed
1025,790,223To be or not IIb: a multi-step process for Epstein-Barr virus latency establishment and consequences for B cell tumorigenesis.PLoS Pathog2015https://conductscience.org/library/papers/25790223PubMed

1 to 10 of 93

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Cited by47

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 69 citations.

PMIDTitleJournalYearIn PapersSource
42,875,430Epigenetic regulation of humoral immunity: molecular mechanisms, diseases and therapeutic targets.Signal Transduct Target Ther2026https://conductscience.org/library/papers/42875430PubMed
42,844,382A guide to B cell metabolism.Nat Rev Immunol2026https://conductscience.org/library/papers/42844382PubMed
42,667,619An Epstein-Barr virus-encoded snoRNA directs 2'-O-methylation of human rRNAs to control translation and the viral lytic switch.Cell Rep2026https://conductscience.org/library/papers/42667619PubMed
42,639,448The microbiome-EBV axis in carcinogenesis bridges commensal influence and viral oncogenesis.Front Immunol2026https://conductscience.org/library/papers/42639448PubMed
42,605,204Evolution and Mechanistic Insights of Immunometabolism in Metabolic Diseases and Infections.Scand J Immunol2026https://conductscience.org/library/papers/42605204PubMed
42,515,039Omics-Level Approaches to Studying Gammaherpesvirus Infection.Pathogens2026https://conductscience.org/library/papers/42515039PubMed
42,456,663Systematic investigation reveals extensive Epstein-Barr virus transcriptional regulation of the human genome.Cell Genom2026https://conductscience.org/library/papers/42456663PubMed
42,409,736[Construction of a methionine metabolism-related prognostic signature and the effect of targeting methionine metabolism on diffuse large B-cell lymphoma].Zhonghua Xue Ye Xue Za Zhi2026https://conductscience.org/library/papers/42409736PubMed
42,294,882Arginine metabolism supports de novo pyrimidine biosynthesis to block DNA damage and maintain Epstein-Barr virus latency.mBio2026https://conductscience.org/library/papers/42294882PubMed
42,146,561Methionine Deprivation-induced Reprogramming of Hepatic Rhythms Is Mediated by Glucocorticoid Receptor.bioRxiv2026https://conductscience.org/library/papers/42146561PubMed

1 to 10 of 47

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Genes35

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AHCY191PubTator's text mininghttps://conductscience.org/library/genes/191NCBI Gene
CD19930PubTator's text mininghttps://conductscience.org/library/genes/930NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD40LG959PubTator's text mininghttps://conductscience.org/library/genes/959NCBI Gene
CP1,356PubTator's text mininghttps://conductscience.org/library/genes/1356NCBI Gene
DDX11,653PubTator's text mininghttps://conductscience.org/library/genes/1653NCBI Gene
DNMT11,786PubTator's text mininghttps://conductscience.org/library/genes/1786NCBI Gene
EHMT210,919PubTator's text mininghttps://conductscience.org/library/genes/10919NCBI Gene
EZH22,146PubTator's text mininghttps://conductscience.org/library/genes/2146NCBI Gene
FCER22,208PubTator's text mininghttps://conductscience.org/library/genes/2208NCBI Gene

1 to 10 of 35

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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