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Paper · 38540669

HIIT Promotes M2 Macrophage Polarization and Sympathetic Nerve Density to Induce Adipose Tissue Browning in T2DM Mice.

Guo Y and 4 others. Biomolecules, 2024. Cited by 17 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. HIIT Promotes M2 Macrophage Polarization and Sympathetic Nerve Density to Induce Adipose Tissue Browning in T2DM Mice. Papers, record 38540669. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/38540669

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
HIIT Promotes M2 Macrophage Polarization and Sympathetic Nerve Density to Induce Adipose Tissue Browning in T2DM Mice.
PubMed
Journal
Biomolecules
PubMed
Year
2024
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
17
iCite
Relative citation ratio, by iCite
2.5, provisional
iCite
Revised in PubMed
2026-04-13
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Guo YYifan
2Zhang QQilong
3Yang DDan
4Chen PPeijie
5Xiao WWeihua

Source PubMed

Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Diabetes Mellitus, Type 2Major topic
High-Intensity Interval TrainingMajor topic
Male
Animals
Mice
Mice, Inbred C57BL
Adipose Tissue
Macrophages
Adipose Tissue, White
Glucose
Membrane Proteins

Source PubMed

Grants6

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
32371185the National Natural Science Foundation of ChinaPubMedPubMed
23010504200the Shanghai Science and Technology Plan ProjectPubMedPubMed
20SG50Shanghai Education Development Foundation and Shanghai Municipale Education CommissionPubMedPubMed
YJSCX-2023-018the Research and Innovation Grant for Graduate Students, Shanghai University of SportYJSCX202301PubMedNIH RePORTER
2022KF001the Key Lab of Exercise and Health Sciences of Ministry of Education (Shanghai University of Sport)PubMedPubMed
11DZ2261100the Shanghai Key Lab of Human Performance (Shanghai University of Sport)PubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References36

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
127,458,196Abandoning M1/M2 for a Network Model of Macrophage Function.Circ Res2016https://conductscience.org/library/papers/27458196PubMed
235,029,593Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine.Med Sci Sports Exerc2022https://conductscience.org/library/papers/35029593PubMed
334,782,792Slit3 secreted from M2-like macrophages increases sympathetic activity and thermogenesis in adipose tissue.Nat Metab2021https://conductscience.org/library/papers/34782792PubMed
436,170,659OPA1 Regulates Lipid Metabolism and Cold-Induced Browning of White Adipose Tissue in Mice.Diabetes2022https://conductscience.org/library/papers/36170659PubMed
530,120,579Emerging Role of AMPK in Brown and Beige Adipose Tissue (BAT): Implications for Obesity, Insulin Resistance, and Type 2 Diabetes.Curr Diab Rep2018https://conductscience.org/library/papers/30120579PubMed
625,035,950Macrophage activation and polarization: nomenclature and experimental guidelines.Immunity2014https://conductscience.org/library/papers/25035950PubMed
730,122,557CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation.Cell Metab2018https://conductscience.org/library/papers/30122557PubMed
823,512,570Acute exercise induces a phenotypic switch in adipose tissue macrophage polarization in diet-induced obese rats.Obesity (Silver Spring)2013https://conductscience.org/library/papers/23512570PubMed
925,347,855Moderate exercise training provides modest protection against adipose tissue inflammatory gene expression in response to high-fat feeding.Physiol Rep2014https://conductscience.org/library/papers/25347855PubMed
1028,459,435Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure.Nat Immunol2017https://conductscience.org/library/papers/28459435PubMed

1 to 10 of 36

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Cited by8

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 17 citations.

PMIDTitleJournalYearIn PapersSource
42,563,997Underlying mechanisms of exercise protection against diabetes mellitus: a narrative review.Front Endocrinol (Lausanne)2026https://conductscience.org/library/papers/42563997PubMed
42,291,260M2 macrophage associated genes shape prognosis and tumor progression in human colorectal cancer.iScience2026https://conductscience.org/library/papers/42291260PubMed
41,594,656BDH1 Mediates Aerobic Exercise-Induced Improvement in Skeletal Muscle Metabolic Remodeling in Type 2 Diabetes Mellitus.Biomolecules2026https://conductscience.org/library/papers/41594656PubMed
41,594,545Resistance Exercise Counteracts Skeletal Muscle Atrophy in T2DM Mice by Upregulating FGF21 and Activating PI3K/Akt Pathway.Biomolecules2025https://conductscience.org/library/papers/41594545PubMed
40,643,547The Effects of Different Types of Exercise on Pulmonary Inflammation and Fibrosis in Mice with Type 2 Diabetes Mellitus.Cells2025https://conductscience.org/library/papers/40643547PubMed
39,696,579High-intensity interval training or lactate administration combined with aerobic training enhances visceral fat loss while promoting VMH neuroplasticity in female rats.Lipids Health Dis2024https://conductscience.org/library/papers/39696579PubMed
39,618,876The Role of Exercise in Regulating the Generation of Extracellular Vesicles in Cardiovascular Diseases.Rev Cardiovasc Med2024https://conductscience.org/library/papers/39618876PubMed
39,590,824Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms.Metabolites2024https://conductscience.org/library/papers/39590824PubMed

Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ARG1383PubTator's text mininghttps://conductscience.org/library/genes/383NCBI Gene
BDNF627PubTator's text mininghttps://conductscience.org/library/genes/627NCBI Gene
CCL26,347PubTator's text mininghttps://conductscience.org/library/genes/6347NCBI Gene
CXCL149,547PubTator's text mininghttps://conductscience.org/library/genes/9547NCBI Gene
GAP432,596PubTator's text mininghttps://conductscience.org/library/genes/2596NCBI Gene
IL103,586PubTator's text mininghttps://conductscience.org/library/genes/3586NCBI Gene
ISYNA151,477PubTator's text mininghttps://conductscience.org/library/genes/51477NCBI Gene
ITGAX3,687PubTator's text mininghttps://conductscience.org/library/genes/3687NCBI Gene
MRC14,360PubTator's text mininghttps://conductscience.org/library/genes/4360NCBI Gene
NGF4,803PubTator's text mininghttps://conductscience.org/library/genes/4803NCBI Gene

1 to 10 of 13

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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