Paper3965500
Variability in purified dysfunctional C1(-)-inhibitor proteins from patients with hereditary angioneurotic edema. Functional and analytical gel studies.
Donaldson VH and 7 others. J Clin Invest, 1985. Cited by 54 papers, by iCite.
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ConductScience Library. Variability in purified dysfunctional C1(-)-inhibitor proteins from patients with hereditary angioneurotic edema. Functional and analytical gel studies. Papers, record 3965500. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/3965500
Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics5
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| Angioedema | Major topic |
| Complement C1 Inactivator Proteins | Major topic |
| Electrophoresis, Polyacrylamide Gel | |
| Humans | |
| Sodium Dodecyl Sulfate |
Source PubMed
Grants4
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| AI-21163 | NIAID NIH HHS | United States | P01AI021163 | PubMed and NIH | NIH RePORTER |
| HL-15690 | NHLBI NIH HHS | United States | R01HL015690 | PubMed and NIH | NIH RePORTER |
| RR-02172 | NCRR NIH HHS | United States | M01RR002172 | PubMed and NIH | NIH RePORTER |
| P50AI021163 | NIH | NIH RePORTER |
References28
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 5,435,787 | Interaction of plasma kallikrein with the C1 inhibitor. | J Immunol | 1970 | https://conductscience.org/library/papers/5435787 | PubMed |
| 2 | 4,908,547 | Hereditary angio-oedema treated with E-aminocaproic acid. | Br J Dermatol | 1969 | https://conductscience.org/library/papers/4908547 | PubMed |
| 3 | 5,432,063 | Cleavage of structural proteins during the assembly of the head of bacteriophage T4. | Nature | 1970 | https://conductscience.org/library/papers/5432063 | PubMed |
| 4 | 5,475,635 | Plasminogen: purification from human plasma by affinity chromatography. | Science | 1970 | https://conductscience.org/library/papers/5475635 | PubMed |
| 5 | 4,107,267 | Genetically determined heterogeneity of the C1 esterase inhibitor in patients with hereditary angioneurotic edema. | J Clin Invest | 1971 | https://conductscience.org/library/papers/4107267 | PubMed |
| 6 | 4,107,360 | Purification of the first component of human complement by affinity chromatography on human globulin linked to sepharose. | J Immunol | 1971 | https://conductscience.org/library/papers/4107360 | PubMed |
| 7 | 4,274,092 | Hereditary angio-oedema: a review with particular reference to pathogenesis and treatment. | Clin Allergy | 1971 | https://conductscience.org/library/papers/4274092 | PubMed |
| 8 | 4,826,936 | Defective activation of clotting, fibrinolytic, and permeability-enhancing systems in human Fletcher trait plasma. | Circ Res | 1974 | https://conductscience.org/library/papers/4826936 | PubMed |
| 9 | 4,857,625 | A simple method for the isolation of the subcomponents of the first component of complement by affinity chromatography. | J Immunol | 1974 | https://conductscience.org/library/papers/4857625 | PubMed |
| 10 | 123,251 | Studies on human plasma C1 inactivator-enzyme interactions. I. Mechanisms of interaction with C1s, plasmin, and trypsin. | J Clin Invest | 1975 | https://conductscience.org/library/papers/123251 | PubMed |
| 11 | 59,937 | Alpha 2-macroglobulin and antithrombin-heparin cofactor: modulators of hemostatic and inflammatory reactions. Alpha 2-macroglobulin. | Prog Hemost Thromb | 1976 | https://conductscience.org/library/papers/59937 | PubMed |
| 12 | 412,531 | Antithrombin Pittsburgh: an alpha1-antitrypsin variant causing hemorrhagic disease. | Blood | 1978 | https://conductscience.org/library/papers/412531 | PubMed |
| 13 | 284,420 | Interactions among Hageman factor, plasma prekallikrein, high molecular weight kininogen, and plasma thromboplastin antecedent. | Proc Natl Acad Sci U S A | 1979 | https://conductscience.org/library/papers/284420 | PubMed |
| 14 | 6,245,704 | Kinetics of reaction of human C1-inhibitor with the human complement system proteases C1r and C1s. | Biochim Biophys Acta | 1980 | https://conductscience.org/library/papers/6245704 | PubMed |
| 15 | 7,400,662 | The relative amidolytic activity of Hageman factor (factor XII) and its fragments. The effect of high-molecular-weight kininogen and kaolin. | J Lab Clin Med | 1980 | https://conductscience.org/library/papers/7400662 | PubMed |
| 16 | 6,914,195 | Human plasma kallikrein. A rapid purification method with high yield. | Biochem J | 1981 | https://conductscience.org/library/papers/6914195 | PubMed |
| 17 | 6,460,805 | Macrophage surface component gp160: sensitivity to plasmin and other proteases. | J Immunol | 1982 | https://conductscience.org/library/papers/6460805 | PubMed |
| 18 | 6,211,203 | Complexes between C1-inhibitor, kallikrein, high molecular weight kininogen, plasma thromboplastin antecedent, and plasmin in normal human plasma and hereditary angioneurotic edema plasmas containing dysmorphic C1-inhibitors: role of cold activation. | Blood | 1982 | https://conductscience.org/library/papers/6211203 | PubMed |
| 19 | 6,833,491 | Behavior in vivo of normal and dysfunctional C1 inhibitor in normal subjects and patients with hereditary angioneurotic edema. | J Clin Invest | 1983 | https://conductscience.org/library/papers/6833491 | PubMed |
| 20 | 6,602,754 | Heparin-stimulated modification of C1-inhibitor by subcomponent C1s of human complement. | Hoppe Seylers Z Physiol Chem | 1983 | https://conductscience.org/library/papers/6602754 | PubMed |
Cited by17
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 54 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 27,459,852 | HAE Pathophysiology and Underlying Mechanisms. | Clin Rev Allergy Immunol | 2016 | https://conductscience.org/library/papers/27459852 | PubMed |
| 9,510,626 | Hereditary angioedema: an unusual case in an African-American woman. | J Natl Med Assoc | 1998 | https://conductscience.org/library/papers/9510626 | PubMed |
| 9,234,243 | Degradation of C1-inhibitor by plasmin: implications for the control of inflammatory processes. | Mol Med | 1997 | https://conductscience.org/library/papers/9234243 | PubMed |
| 8,485,912 | C1 inhibitor functional deficiency in systemic lupus erythematosus (SLE). | Clin Exp Immunol | 1993 | https://conductscience.org/library/papers/8485912 | PubMed |
| 8,450,054 | Transinhibition of C1 inhibitor synthesis in type I hereditary angioneurotic edema. | J Clin Invest | 1993 | https://conductscience.org/library/papers/8450054 | PubMed |
| 7,883,978 | Unique C1 inhibitor dysfunction in a kindred without angioedema. II. Identification of an Ala443-->Val substitution and functional analysis of the recombinant mutant protein. | J Clin Invest | 1995 | https://conductscience.org/library/papers/7883978 | PubMed |
| 3,818,946 | Molecular basis for the deficiency of complement 1 inhibitor in type I hereditary angioneurotic edema. | J Clin Invest | 1987 | https://conductscience.org/library/papers/3818946 | PubMed |
| 3,734,104 | Demonstration of modified inactive first component of complement (C1) inhibitor in the plasmas of C1 inhibitor-deficient patients. | J Clin Invest | 1986 | https://conductscience.org/library/papers/3734104 | PubMed |
| 3,178,731 | Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444----His) mutation. | Biochem J | 1988 | https://conductscience.org/library/papers/3178731 | PubMed |
| 2,723,063 | Type I C1 inhibitor deficiency with a small messenger RNA resulting from deletion of one exon. | J Clin Invest | 1989 | https://conductscience.org/library/papers/2723063 | PubMed |
| 2,723,058 | Acquired C1 inhibitor (C1-INH) deficiency type II. Replacement therapy with C1-INH and analysis of patients' C1-INH and anti-C1-INH autoantibodies. | J Clin Invest | 1989 | https://conductscience.org/library/papers/2723058 | PubMed |
| 2,536,404 | Autoantibody facilitated cleavage of C1-inhibitor in autoimmune angioedema. | J Clin Invest | 1989 | https://conductscience.org/library/papers/2536404 | PubMed |
| 2,318,974 | Plasma levels of C1- inhibitor complexes and cleaved C1- inhibitor in patients with hereditary angioneurotic edema. | J Clin Invest | 1990 | https://conductscience.org/library/papers/2318974 | PubMed |
| 2,296,585 | Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene. | Proc Natl Acad Sci U S A | 1990 | https://conductscience.org/library/papers/2296585 | PubMed |
| 2,244,865 | Rapid and sensitive techniques for identification and analysis of 'reactive-centre' mutants of C1-inhibitor proteins contained in type II hereditary angio-oedema plasmas. | Biochem J | 1990 | https://conductscience.org/library/papers/2244865 | PubMed |
| 2,118,657 | Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site. | Proc Natl Acad Sci U S A | 1990 | https://conductscience.org/library/papers/2118657 | PubMed |
| 1,902,490 | Synthesis of C1 inhibitor in fibroblasts from patients with type I and type II hereditary angioneurotic edema. | J Clin Invest | 1991 | https://conductscience.org/library/papers/1902490 | PubMed |
Genes5
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| C1S | 716 | PubTator's text mining | https://conductscience.org/library/genes/716 | NCBI Gene |
| F12 | 2,161 | PubTator's text mining | https://conductscience.org/library/genes/2161 | NCBI Gene |
| KLK4 | 9,622 | PubTator's text mining | https://conductscience.org/library/genes/9622 | NCBI Gene |
| PLG | 5,340 | PubTator's text mining | https://conductscience.org/library/genes/5340 | NCBI Gene |
| SERPING1 | 710 | PubTator's text mining | https://conductscience.org/library/genes/710 | NCBI Gene |
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- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
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Sources 11
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- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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