Disease · EFO_0009505

head injury

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. head injury. Diseases, record EFO_0009505. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0009505

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: head injury; Open Targets
Open Targets ID: EFO_0009505; Open Targets
NCI Thesaurus: C34660; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 9 drugs, from DailyMed; Open Targets

Drugs9

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DESMOPRESSIN ACETATE	CHEMBL1200556	Protein	Approval	DailyMed	2	0	0	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Phase 3	ClinicalTrials.gov	2	2	1	Drugs and targets
DEXTRAN	CHEMBL1697742	Oligosaccharide	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
ALBUMIN HUMAN	CHEMBL1201451	Protein	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
PERFLUORO TERT-BUTYLCYCLOHEXANE	CHEMBL4297413	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
ROSUVASTATIN	CHEMBL1496	Small molecule	Phase 1/2	ClinicalTrials.gov	1	1	1	Drugs and targets
COSYNTROPIN	CHEMBL2103784	Protein	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
METYRAPONE	CHEMBL934	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
PEGORGOTEIN	CHEMBL2108560		Unknown	TTD	1	0	0	Drugs and targets

Targets6

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
AVPR1A	Vasopressin receptor	1	Vasopressin receptor agonist	Approval	https://conductscience.org/library/genes/552	Drugs and targets
AVPR1B	Vasopressin receptor	1	Vasopressin receptor agonist	Approval	https://conductscience.org/library/genes/553	Drugs and targets
AVPR2	Vasopressin receptor	1	Vasopressin receptor agonist	Approval	https://conductscience.org/library/genes/554	Drugs and targets
CYP11B1	Cytochrome P450 11B1, mitochondrial	1	Cytochrome P450 11B1, mitochondrial inhibitor	Unknown	https://conductscience.org/library/genes/1584	Drugs and targets
HMGCR	3-hydroxy-3-methylglutaryl-coenzyme A reductase	1	HMG-CoA reductase inhibitor	Phase 1/2	https://conductscience.org/library/genes/3156	Drugs and targets
MC2R	Adrenocorticotropic hormone receptor	1	Melanocortin receptor 2 agonist	Unknown	https://conductscience.org/library/genes/4158	Drugs and targets

Trials6

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00174980	Study of Oxycyte in Severe Closed Head Injury	Phase 2	9	2026-02-24	Traumatic Brain Injury	PERFLUORO TERT-BUTYLCYCLOHEXANE	Its record names the disease	ClinicalTrials.gov
NCT01642524	The Toronto Prehospital Hypertonic Resuscitation Head Injury and Multi Organ Dysfunction Trial (TOPHR HIT)	Phase 3	114		Traumatic Brain Injury	DEXTRAN	Its record names the disease	ClinicalTrials.gov
NCT00878631	Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline	Phase 2/3	113		Brain Injuries	SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT00152685	High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury	Phase 2/3	40		Severe Head Injury	ALBUMIN HUMAN	Its record names the disease	ClinicalTrials.gov
NCT00990028	Effect of Rosuvastatin on Cytokines After Traumatic Brain Injury	Phase 1/2	40		Head Injury	ROSUVASTATIN	Its record names the disease	ClinicalTrials.gov
NCT00006270	Study of the Approximate Entropy of Adrenocorticotropic Hormone and Cortisol Secretion in Patients With Head Injury		32		Brain Injury, Craniocerebral Trauma	COSYNTROPIN, METYRAPONE	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials3

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
23289819	DERIVED	1	PubMed
20082712	DERIVED	1	PubMed
19930566	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/EFO_0009505

GET https://conductscience.org/api/diseases/v1/EFO_0009505/drugs

API reference For AI assistants