Disease · MONDO_0007005
ulcerative proctosigmoiditis
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. ulcerative proctosigmoiditis. Diseases, record MONDO_0007005. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0007005
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- ulcerative proctosigmoiditis
- Open Targets ID
- MONDO_0007005
- Other names
- Proctocolitis, Proctosigmoiditis (disorder), chronic ulcerative rectosigmoiditis (disorder), proctosigmoiditis, ulcerative (chronic) proctosigmoiditis
- Highest stage of its drugs
- Phase 3, for 1 of its 4 drugs, from ClinicalTrials.gov
Source Open Targets
Drugs4
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| BUDESONIDE | CHEMBL1370 | Small molecule | Phase 3 | ClinicalTrials.gov | 3 | 3 | 3 | Drugs and targets |
| NICLOSAMIDE | CHEMBL1448 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ALOE | CHEMBL2108221 | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets | |
| MESALAMINE | CHEMBL704 | Small molecule | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets5
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ALOX5 | Polyunsaturated fatty acid 5-lipoxygenase | 1 | Arachidonate 5-lipoxygenase inhibitor | Unknown | https://conductscience.org/library/genes/240 | Drugs and targets |
| NR3C1 | Glucocorticoid receptor | 1 | Glucocorticoid receptor agonist | Phase 3 | https://conductscience.org/library/genes/2908 | Drugs and targets |
| PPARG | Peroxisome proliferator-activated receptor gamma | 1 | Peroxisome proliferator-activated receptor gamma agonist | Unknown | https://conductscience.org/library/genes/5468 | Drugs and targets |
| PTGS1 | Cyclooxygenase | 1 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5742 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 1 | Cyclooxygenase inhibitor | Unknown | https://conductscience.org/library/genes/5743 | Drugs and targets |
Trials6
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01008423 | Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis | Phase 3 | 281 | 2019-08-14 | Proctitis, Proctosigmoiditis | BUDESONIDE | Its record names the disease | ClinicalTrials.gov |
| NCT01008410 | Efficacy and Safety of Budesonide Foam for Participants With Active Mild to Moderate Ulcerative Proctitis or Proctosigmoiditis | Phase 3 | 265 | 2019-08-14 | Proctitis, Proctosigmoiditis | BUDESONIDE | Its record names the disease | ClinicalTrials.gov |
| NCT01349673 | The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis | Phase 3 | 114 | 2019-08-14 | Proctitis, Proctosigmoiditis | BUDESONIDE | Its record names the disease | ClinicalTrials.gov |
| NCT02368743 | QUality of Life in pAtients With Mild to modeRate Active procTitis Treated by mesalaZine (Pentasa®) | 117 | Distal Ulcerative Colitis | MESALAMINE | Its record names the disease | ClinicalTrials.gov | ||
| NCT04753775 | RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF ENEMA ALOE VERA GEL IN ACTIVE ULCERATIVE PROCTOSIGMOIDITIS. | Not applicable | 44 | Aloe Vera Gel, Proctosigmoiditis, Remission, Trial, Ulcerative Colitis (UC) | ALOE | Its record names the disease | ClinicalTrials.gov | |
| NCT03521232 | A Study of Niclosamide Enemas in Subjects With Active Ulcerative Proctitis or Ulcerative Proctosigmoiditis | Phase 1/2 | 27 | Ulcerative Colitis, Ulcerative Proctitis, Ulcerative Proctosigmoiditis | NICLOSAMIDE | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials4
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Budesonide vs Placebo: deaths from any cause | 0 of 134 | 0 of 147 | 281 | NCT01008423 | Trial comparisons |
| Budesonide vs Placebo: serious adverse events | 3 of 134 | 0 of 147 | 281 | NCT01008423 | Trial comparisons |
| Budesonide vs Placebo: deaths from any cause | 0 of 134 | 0 of 131 | 265 | NCT01008410 | Trial comparisons |
| Budesonide vs Placebo: serious adverse events | 2 of 134 | 3 of 131 | 265 | NCT01008410 | Trial comparisons |
Papers from its trials3
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0007005
GET https://conductscience.org/api/diseases/v1/MONDO_0007005/drugs