Drug · CHEMBL112

ACETAMINOPHEN

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. ACETAMINOPHEN. Drugs and targets, record CHEMBL112. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL112

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Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: ACETAMINOPHEN; ChEMBL
ChEMBL ID: CHEMBL112; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Abdine, Acephen, Acetaminophen component of allay, Acetaminophen component of anexsia, Acetaminophen component of anoquan, Acetaminophen component of apadaz, Acetaminophen component of bancap, Acetaminophen component of bancap hc, Acetaminophen component of bucet, Acetaminophen component of butapap, Acetaminophen component of co-gesic, Acetaminophen component of codrix, Acetaminophen component of combogesic, Acetaminophen component of combogesic iv, Acetaminophen component of darvocet, Acetaminophen component of dhc plus, Acetaminophen component of dolene ap-65, Acetaminophen component of drixoral plus, Acetaminophen component of duradyne dhc, Acetaminophen component of esgic, Acetaminophen component of excedrin, Acetaminophen component of femcet, Acetaminophen component of fioricet, Acetaminophen component of hy-phen, Acetaminophen component of lorcet-hd, Acetaminophen component of lortab, Acetaminophen component of medigesic plus, Acetaminophen component of norcet, Acetaminophen component of norco, Acetaminophen component of oxycet, Acetaminophen component of percocet, Acetaminophen component of phrenilin, Acetaminophen component of roxicet, Acetaminophen component of roxilox, Acetaminophen component of sedapap, Acetaminophen component of synalgos-dc-a, Acetaminophen component of talacen, Acetaminophen component of tencon, Acetaminophen component of trezix, Acetaminophen component of triad, Acetaminophen component of triaprin, Acetaminophen component of tycolet, Acetaminophen component of tylox, Acetaminophen component of ultracet, Acetaminophen component of vicodin, Acetaminophen component of wygesic, Acetaminophen component of xartemis, Acetaminophen component of zydone, Alvedon, Angiers, Calpol, Calpol six plus, Calpol six plus fastmelts, Child lemsip, Cupanol, Dafalgan, Disprol, Disprol infant, Disprol jnr, Disprol paed, Fennings, Galpamol, Hedex, Infadrops, Infants' feverall, Injectapap, Junior parapaed, Mandanol, Medinol, Medinol for children, Medinol over 6, Medinol under 6, Medised plain, Miradol, Neopap, Ofirmev, Paldesic, Panadol, Panadol actifast, Panadol actifast solb, Panadol advan, Panadol jnr, Panadol oa, Panaleve, Panaleve 6 plus, Paramin, Parapaed jnr, Parapaed six plus, Paravict, Perfalgan, Placidex, Rimadol, Salzone, Tixymol, Tramil 500, Tylenol, Tylenol (caplet), Tylenol (geltab); ChEMBL
Other names: Biocetamol, Doliprane, Efferalgan, N-acetyl-p-aminophenol, NSC-109028, NSC-3991, P-hydroxy-acetanilid, Paracetamol, Paracetamolum, Vermidon; ChEMBL
DrugBank: DB00316; DrugBank
InChIKey: RZVAJINKPMORJF-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 18 of its 115 diseases, from ATC, DailyMed, PMDA and TTD; Open Targets

Targets4

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
FAAH	Fatty-acid amide hydrolase 1	Anandamide amidohydrolase inhibitor	INHIBITOR	https://conductscience.org/library/genes/2166
PTGS1	Cyclooxygenase	Cyclooxygenase inhibitor	INHIBITOR	https://conductscience.org/library/genes/5742
PTGS2	Cyclooxygenase	Cyclooxygenase inhibitor	INHIBITOR	https://conductscience.org/library/genes/5743
TRPV1	Transient receptor potential cation channel subfamily V member 1	Vanilloid receptor opener	OPENER	https://conductscience.org/library/genes/7442

Source ChEMBL

Diseases115

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Approval	ATC, DailyMed, PMDA and TTD	350	105	https://conductscience.org/library/drugs?q=HP_0012531
Patent ductus arteriosus	Phase 3	ClinicalTrials.gov	26	26	https://conductscience.org/library/drugs?q=HP_0001643
osteoarthritis	Approval	PMDA	20	19	https://conductscience.org/library/drugs?q=MONDO_0005178
Fever	Approval	ATC, DailyMed and PMDA	67	18	https://conductscience.org/library/drugs?q=HP_0001945
migraine disorder	Approval	DailyMed	109	12	https://conductscience.org/library/drugs?q=MONDO_0005277
Low back pain	Phase 3	ClinicalTrials.gov	12	12	https://conductscience.org/library/drugs?q=HP_0003419
osteoarthritis, knee	Phase 3	ClinicalTrials.gov	7	7	https://conductscience.org/library/drugs?q=MONDO_0005416
Headache	Approval	DailyMed	113	5	https://conductscience.org/library/drugs?q=HP_0002315
toothache	Approval	DailyMed	16	5	https://conductscience.org/library/drugs?q=EFO_0010072
acute kidney injury	Phase 3	ClinicalTrials.gov	5	5	https://conductscience.org/library/drugs?q=MONDO_0002492

1 to 10 of 115Source Open Targets

See all 115 diseases

Trials1,094

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 3 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT04452344	Opioid Analgesic Reduction Study	Phase 3	1,815	2024-07-30	acetaminophen	Its name	ClinicalTrials.gov
NCT03472469	MAST Trial: Multi-modal Analgesic Strategies in Trauma	Phase 4	1,561	2021-06-10	acetaminophen	Its name	ClinicalTrials.gov
NCT03330119	Determining the Effect of an "Alternate Recovery Protocol" Versus Current Standard of Care After Cesarean Section	Phase 3	1,494	2021-03-02	acetaminophen	Its name	ClinicalTrials.gov
NCT02311881	A 12-Week Efficacy Study of Paracetamol 1000mg Sustained-release Tablets in Patients With Osteoarthritis	Phase 3	960	2017-04-07	paracetamol	Its name	ClinicalTrials.gov
NCT01392378	Study Assessing the Effect of Medications to Prevent Fever on Prevenar 13®	Phase 4	908	2014-02-26	paracetamol	Its name	ClinicalTrials.gov
NCT01973205	Efficacy and Safety of Acetaminophen and Aspirin Versus Placebo in the Acute Treatment of Migraine	Phase 3	900	2015-06-11	acetaminophen	Its name	ClinicalTrials.gov
NCT01235949	Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment	Phase 4	850	2019-01-31	paracetamol	Its name	ClinicalTrials.gov
NCT00489424	Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass	Phase 4	793	2009-09-14	acetaminophen	Its name	ClinicalTrials.gov
NCT01248468	Efficacy and Safety of Acetaminophen, Aspirin and Caffeine With Sumatriptan in the Acute Treatment of Migraine	Phase 4	752	2012-07-30	acetaminophen	Its name	ClinicalTrials.gov
NCT00496015	Prophylactic Antipyretic Treatment in Children Receiving Booster Dose of Pneumococcal Conjugate Vaccine GSK1024850A	Phase 3	750	2019-01-18	paracetamol	Its name	ClinicalTrials.gov

1 to 10 of 1,094

See all 1,094 trials

Comparisons in its trials404

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Non-Opioid vs Opioid: Number of Participants Receiving Rescue Medication	26 of 909	54 of 906	1,815	NCT04452344	Trial comparisons
Non-Opioid vs Opioid: deaths from any cause	0 of 909	0 of 906	1,815	NCT04452344	Trial comparisons
Non-Opioid vs Opioid: serious adverse events	1 of 909	2 of 906	1,815	NCT04452344	Trial comparisons
Original MMPR - Descending Dose Arm vs MAST MMPR - Escalating Dose Arm: Number of Participants Discharged From the Hospital With an Opioid Prescription	527 of 787	476 of 774	1,561	NCT03472469	Trial comparisons
Original MMPR - Descending Dose Arm vs MAST MMPR - Escalating Dose Arm: deaths from any cause	29 of 787	36 of 774	1,561	NCT03472469	Trial comparisons
Original MMPR - Descending Dose Arm vs MAST MMPR - Escalating Dose Arm: serious adverse events	29 of 787	36 of 774	1,561	NCT03472469	Trial comparisons
Alternate Management vs Control: deaths from any cause	0 of 475	0 of 641	1,116	NCT03330119	Trial comparisons
Alternate Management vs Control: serious adverse events	0 of 475	0 of 641	1,116	NCT03330119	Trial comparisons
Acetaminophen 250 mg and Aspirin 250 mg vs Placebo: Number of Subjects Who Are Pain Free at the 2-hour Assessment	90 of 408	69 of 415	823	NCT01973205	Trial comparisons
Acetaminophen 250 mg and Aspirin 250 mg vs Placebo: serious adverse events	1 of 408	0 of 415	823	NCT01973205	Trial comparisons

1 to 10 of 404

See all 404 comparisons in its trials

Papers from its trials575

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40889095	RESULT	1	PubMed
40678377	RESULT	1	PubMed
39948605	RESULT	1	PubMed
39578300	RESULT	1	PubMed
39238029	RESULT	1	PubMed
37978159	RESULT	1	PubMed
37266144	RESULT	1	PubMed
36837467	RESULT	1	PubMed
36295622	RESULT	1	PubMed
35869710	RESULT	1	PubMed

1 to 10 of 575

See all 575 papers from its trials

Tests in its trials8

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Rapid Visual Information Processing	3	3	ConductCognition
Choice Reaction Time	1	1	ConductCognition
One-Touch Tower Planning	1	1	ConductCognition
Paired Associate Learning	1	0	ConductCognition
Simple Reaction Time	1	1	ConductCognition
Trail Making Test A	1	0	ConductCognition
Trail Making Test B	1	0	ConductCognition
Verbal Learning	1	1	ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL112

GET https://conductscience.org/api/drugs/v1/CHEMBL112/diseases?page=2

API reference For AI assistants