Drug · CHEMBL80
NALOXONE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. NALOXONE. Drugs and targets, record CHEMBL80. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL80
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Open Targets' highest stage
- Approval, for 2 of its 31 diseases, from ATC, EMA Human Drugs and TTD
- Open Targets
Targets3
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| OPRD1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta antagonist | ANTAGONIST | https://conductscience.org/library/genes/4985 |
| OPRK1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta antagonist | ANTAGONIST | https://conductscience.org/library/genes/4986 |
| OPRM1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta antagonist | ANTAGONIST | https://conductscience.org/library/genes/4988 |
Source ChEMBL
Diseases31
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
1 to 10 of 31Source Open Targets
See all 31 diseasesTrials201
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 2 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT00315341 | Starting Treatment With Agonist Replacement Therapies (START) | Phase 4 | 1,269 | 2017-01-06 | naloxone | Its name | ClinicalTrials.gov |
| NCT02357901 | Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine | Phase 3 | 665 | 2018-02-20 | buprenorphine/naloxone | A combination that names it | ClinicalTrials.gov |
| NCT00640835 | Safety and Tolerability of Buprenorphine/Naloxone Film Strips | Phase 2 | 382 | 2010-10-26 | naloxone | Its name | ClinicalTrials.gov |
| NCT01848054 | Study to Assess Efficacy and Safety of BNX Sublingual Tablets for the Induction of Treatment of Opioid Dependence | Phase 3 | 313 | 2015-06-24 | buprenorphine/naloxone | A combination that names it | ClinicalTrials.gov |
| NCT01936857 | Buprenorphine to Improve HIV Care Engagement and Outcomes | Phase 4 | 281 | 2020-06-24 | buprenorphine/naloxone | A combination that names it | ClinicalTrials.gov |
| NCT01788306 | Project OOPEN: Opioid Overdose Prevention, Education and Intervention | Phase 4 | 256 | 2022-01-11 | naloxone | Its name | ClinicalTrials.gov |
| NCT01666119 | An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjects | Phase 2 | 249 | 2017-04-04 | naloxone | Its name | ClinicalTrials.gov |
| NCT00784810 | A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis | Phase 4 | 247 | 2011-11-02 | naloxone | Its name | ClinicalTrials.gov |
| NCT00605033 | A Randomized Acceptability and Safety Study of the Transfer From Subutex to Suboxone in Opioid- Dependent Subjects (Study P04843)(COMPLETED) | Phase 4 | 241 | 2010-06-30 | buprenorphine hydrochloride + naloxone | A combination that names it | ClinicalTrials.gov |
| NCT02581111 | Naloxone for Optimizing Hypoxemia Of Lung Donors | Phase 2/3 | 199 | 2018-10-16 | naloxone | Its name | ClinicalTrials.gov |
1 to 10 of 201
See all 201 trialsComparisons in its trials78
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Buprenorphine/Nx vs Methadone: serious adverse events | 38 of 727 | 45 of 520 | 1,247 | NCT00315341 | Trial comparisons |
Buprenorphine/Naloxone Film Strip Administered Sublingually vs Buprenorphine/Naloxone Film Strip Administered Buccally: Number of Subjects With Treatment-emergent Adverse Events Associated With the Oral Cavity. | 11 of 194 | 16 of 188 | 382 | NCT00640835 | Trial comparisons |
| Buprenorphine/Naloxone Film Strip Administered Sublingually vs Buprenorphine/Naloxone Film Strip Administered Buccally: serious adverse events | 4 of 194 | 2 of 188 | 382 | NCT00640835 | Trial comparisons |
| BNX Sublingual Tablets Induction vs Buprenorphine Induction: Retention in Treatment in the Full Analysis Population | 132 of 155 | 147 of 155 | 310 | NCT01848054 | Trial comparisons |
| BNX Sublingual Tablets Induction vs Buprenorphine Induction: serious adverse events | 1 of 155 | 2 of 155 | 310 | NCT01848054 | Trial comparisons |
| Buprenorphine/Naloxone vs Methadone Maintenance Therapy: Number of Participants in Retention in HIV Care | 111 of 141 | 118 of 140 | 281 | NCT01936857 | Trial comparisons |
| Buprenorphine/Naloxone vs Methadone Maintenance Therapy: deaths from any cause | 7 of 141 | 3 of 140 | 281 | NCT01936857 | Trial comparisons |
| Buprenorphine/Naloxone vs Methadone Maintenance Therapy: serious adverse events | 10 of 141 | 4 of 140 | 281 | NCT01936857 | Trial comparisons |
| Buprenorphine/Naloxone vs Methadone Maintenance Therapy: Number of Participants in Receipt of Antiretroviral Therapy (ART) | 108 of 128 | 116 of 131 | 259 | NCT01936857 | Trial comparisons |
| BNX Sublingual Tablets Induction vs Buprenorphine Induction: Retention in Treatment in the Per Protocol Population | 113 of 128 | 122 of 128 | 256 | NCT01848054 | Trial comparisons |
1 to 10 of 78
See all 78 comparisons in its trialsPapers from its trials112
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Tests in its trials2
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome | Source |
|---|---|---|---|
| Trail Making Test A | 1 | 0 | ConductCognition |
| Trail Making Test B | 1 | 0 | ConductCognition |
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL80
GET https://conductscience.org/api/drugs/v1/CHEMBL80/diseases?page=2