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Paper · 16982811

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.

Liang SC and 6 others. J Exp Med, 2006. Cited by 1,902 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. Papers, record 16982811. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/16982811

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.
PubMed
Journal
J Exp Med
PubMed
Year
2006
PubMed
Publication types
Comparative Study, Journal Article
PubMed
Citations, by iCite
1,902
iCite
Relative citation ratio, by iCite
41.7
iCite
Revised in PubMed
2026-01-28
PubMed

Authors7

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Liang SCSpencer C
2Tan XYXiang-Yang
3Luxenberg DPDeborah P
4Karim RRiyez
5Dunussi-Joannopoulos KKyriaki
6Collins MMary
7Fouser LALynette A

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Antimicrobial Cationic PeptidesMajor topic
CD4-Positive T-LymphocytesMajor topic
Immunity, InnateMajor topic
Interleukin-17Major topic
InterleukinsMajor topic
Signal TransductionMajor topic
Animals
Cell Differentiation
Keratinocytes
Mice
Mice, Transgenic
Polymerase Chain Reaction
Transforming Growth Factor beta
Interleukin-22

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References19

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
112,417,590Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.J Biol Chem2003https://conductscience.org/library/papers/12417590PubMed
212,023,331Cutting edge: immune cells as sources and targets of the IL-10 family members?J Immunol2002https://conductscience.org/library/papers/12023331PubMed
314,634,133Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice.J Immunol2003https://conductscience.org/library/papers/14634133PubMed
414,662,908Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation.J Exp Med2003https://conductscience.org/library/papers/14662908PubMed
515,120,653Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2.Int Immunopharmacol2004https://conductscience.org/library/papers/15120653PubMed
615,308,104IL-22 increases the innate immunity of tissues.Immunity2004https://conductscience.org/library/papers/15308104PubMed
715,485,625Interleukin-17 family members and inflammation.Immunity2004https://conductscience.org/library/papers/15485625PubMed
815,657,292IL-23 drives a pathogenic T cell population that induces autoimmune inflammation.J Exp Med2005https://conductscience.org/library/papers/15657292PubMed
915,749,908IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes.J Immunol2005https://conductscience.org/library/papers/15749908PubMed
1015,818,686Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine.Arthritis Rheum2005https://conductscience.org/library/papers/15818686PubMed

1 to 10 of 19

See all 19 references

Cited by1,165

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,902 citations.

PMIDTitleJournalYearIn PapersSource
42,920,770T-cell dynamics after intracerebral hemorrhage and stroke-associated pneumonia: the vicious cycle of the lung-brain axis.Front Neurosci2026https://conductscience.org/library/papers/42920770PubMed
42,886,333Incidence and Risk Factors of Treatment-Emergent Eczematous Reactions in Patients with Psoriasis Treated with Biologics: A Systematic Review and Meta-Analysis.BioDrugs2026https://conductscience.org/library/papers/42886333PubMed
42,709,895IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response.PLoS Pathog2026https://conductscience.org/library/papers/42709895PubMed
42,678,599ADAM10's combined influence on the diagnostic usefulness of IL 22, IL 10, IL-17 A, and IL-17D in autism spectrum disorders: Predicted role on gut leakiness as co-morbidity.Metab Brain Dis2026https://conductscience.org/library/papers/42678599PubMed
42,620,748GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment.Front Immunol2026https://conductscience.org/library/papers/42620748PubMed
42,536,770IL-22 synergizes with IL-17 to promote mucosal inflammation and bone loss.J Immunol2026https://conductscience.org/library/papers/42536770PubMed
42,488,622CD4+ T-cell immunity to Bordetella pertussis.Discov Immun2026https://conductscience.org/library/papers/42488622PubMed
42,441,234Dysregulation of T Helper 17 Cell Pathway In Vitiligo.Indian J Dermatol2026https://conductscience.org/library/papers/42441234PubMed
42,418,101IL-17A, IL-17RA, and IL-22 as biomarkers in migraine: associations with disease activity and clinical features.Ir J Med Sci2026https://conductscience.org/library/papers/42418101PubMed
42,393,041Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis.Nat Commun2026https://conductscience.org/library/papers/42393041PubMed

1 to 10 of 1,165

See all 1,165 cited by

Genes19

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
DEFB4A1,673PubTator's text mininghttps://conductscience.org/library/genes/1673NCBI Gene
DEFB4B100,289,462PubTator's text mininghttps://conductscience.org/library/genes/100289462NCBI Gene
FN12,335PubTator's text mininghttps://conductscience.org/library/genes/2335NCBI Gene
GAPDH2,597PubTator's text mininghttps://conductscience.org/library/genes/2597NCBI Gene
IL103,586PubTator's text mininghttps://conductscience.org/library/genes/3586NCBI Gene
IL12B3,593PubTator's text mininghttps://conductscience.org/library/genes/3593NCBI Gene
IL17A3,605PubTator's text mininghttps://conductscience.org/library/genes/3605NCBI Gene
IL17F112,744PubTator's text mininghttps://conductscience.org/library/genes/112744NCBI Gene
IL1B3,553PubTator's text mininghttps://conductscience.org/library/genes/3553NCBI Gene

1 to 10 of 19

See all 19 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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