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Paper2139102

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

Young JW and 1 other. J Exp Med, 1990. Cited by 204 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. Papers, record 2139102. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/2139102

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.
PubMed
Journal
J Exp Med
PubMed
Year
1990
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
204
iCite
Relative citation ratio, by iCite
3.83
iCite
Revised in PubMed
2019-05-08
PubMed

Authors2

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Young JWJ W
2Steinman RMR M

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CD4 AntigensMajor topic
Cytotoxicity, ImmunologicMajor topic
Dendritic CellsMajor topic
T-Lymphocytes, CytotoxicMajor topic
T-Lymphocytes, Helper-InducerMajor topic
Antigens, CD
Cell Communication
Cell Separation
Cells, Cultured
Centrifugation, Density Gradient
Humans
Interleukin-2
Leukocytes
Lymphocyte Culture Test, Mixed
Phenotype

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
1R29 AI-26875NIAID NIH HHSUnited StatesR29AI026875PubMed and NIHNIH RePORTER
KO8 CA-00961NCI NIH HHSUnited StatesK08CA000961PubMed and NIHNIH RePORTER
P01 AI-24775NIAID NIH HHSUnited StatesP01AI024775PubMed and NIHNIH RePORTER

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
16,450,246Anti-recipient cytotoxic T lymphocyte precursors are present in the spleens of mice with acute graft versus host disease due to minor histocompatibility antigens.J Immunol1981https://conductscience.org/library/papers/6450246PubMed
27,451,976Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.J Immunol1981https://conductscience.org/library/papers/7451976PubMed
36,975,347T cell growth factor receptors. Quantitation, specificity, and biological relevance.J Exp Med1981https://conductscience.org/library/papers/6975347PubMed
46,977,610Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriers.J Exp Med1982https://conductscience.org/library/papers/6977610PubMed
56,186,923A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease.Nature1983https://conductscience.org/library/papers/6186923PubMed
66,195,259Alloantigen-specific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors.J Immunol1983https://conductscience.org/library/papers/6195259PubMed
76,434,688Response of resting human peripheral blood natural killer cells to interleukin 2.J Exp Med1984https://conductscience.org/library/papers/6434688PubMed
83,871,216Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens.J Immunol1985https://conductscience.org/library/papers/3871216PubMed
96,239,901Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigen-presenting cell) requirements for growth and lymphokine release.J Exp Med1984https://conductscience.org/library/papers/6239901PubMed
103,894,963An in vitro predictive test for graft versus host disease in patients with genotypic HLA-identical bone marrow transplants.N Engl J Med1985https://conductscience.org/library/papers/3894963PubMed
112,933,483Properties of purified T cell subsets. I. In vitro responses to class I vs. class II H-2 alloantigens.J Exp Med1985https://conductscience.org/library/papers/2933483PubMed
123,936,719Monoclonal antibody 9.3 and anti-CD11 antibodies define reciprocal subsets of lymphocytes.Eur J Immunol1985https://conductscience.org/library/papers/3936719PubMed
133,910,556Graft-versus-host reactions and disease.Immunol Rev1985https://conductscience.org/library/papers/3910556PubMed
143,910,558Graft-versus-host disease in dog and man: the Seattle experience.Immunol Rev1985https://conductscience.org/library/papers/3910558PubMed
153,512,763Properties of purified T cell subsets. II. In vivo responses to class I vs. class II H-2 differences.J Exp Med1986https://conductscience.org/library/papers/3512763PubMed
162,873,281Graft rejection and graft-versus-host disease: mirror images.Lancet1986https://conductscience.org/library/papers/2873281PubMed
173,090,451Capacity of purified Lyt-2+ T cells to mount primary proliferative and cytotoxic responses to Ia- tumour cells.Nature1986https://conductscience.org/library/papers/3090451PubMed
183,108,446Variable capacity of L3T4+ T cells to cause lethal graft-versus-host disease across minor histocompatibility barriers in mice.J Exp Med1987https://conductscience.org/library/papers/3108446PubMed
192,955,054Mononuclear phagocytes as targets for cytolytic T lymphocytes.J Immunol Methods1987https://conductscience.org/library/papers/2955054PubMed
202,955,069Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.J Exp Med1987https://conductscience.org/library/papers/2955069PubMed

See all 42 references

Cited by46

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 204 citations.

PMIDTitleJournalYearIn PapersSource
41,630,477A data-driven cartography of NSCLC vaccine research: Quantifying the paradigm shift toward immuno-oncology combination therapies.Hum Vaccin Immunother2026https://conductscience.org/library/papers/41630477PubMed
41,503,128Neoantigen dendritic cell vaccination combined with conventional chemotherapy for a patient with advanced transverse colon cancer.J Surg Case Rep2026https://conductscience.org/library/papers/41503128PubMed
41,148,450Dendritic Cells: at the Crossroads between Oral Tolerance and Food Allergy.Curr Allergy Asthma Rep2025https://conductscience.org/library/papers/41148450PubMed
30,719,026Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy.Front Immunol2018https://conductscience.org/library/papers/30719026PubMed
24,211,847Therapeutic polyclonal human CD8+ CD25+ Fox3+ TNFR2+ PD-L1+ regulatory cells induced ex-vivo.Clin Immunol2013https://conductscience.org/library/papers/24211847PubMed
23,130,928Dendritic cell-based vaccines: barriers and opportunities.Future Oncol2012https://conductscience.org/library/papers/23130928PubMed
21,917,753Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen.Blood2011https://conductscience.org/library/papers/21917753PubMed
20,644,110Interferon gamma licensing of human dendritic cells in T-helper-independent CD8+ alloimmunity.Blood2010https://conductscience.org/library/papers/20644110PubMed
18,971,304Role of dendritic cells in enhancement of herpes simplex virus type 1 latency and reactivation in vaccinated mice.Clin Vaccine Immunol2008https://conductscience.org/library/papers/18971304PubMed
18,798,913The C3H/HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results.Exp Dermatol2008https://conductscience.org/library/papers/18798913PubMed
17,420,764Immunology and immunotherapy approaches for prostate cancer.Prostate Cancer Prostatic Dis2007https://conductscience.org/library/papers/17420764PubMed
17,239,504Generation and functional assessment of antigen-specific T cells stimulated by fusions of dendritic cells and allogeneic breast cancer cells.Vaccine2007https://conductscience.org/library/papers/17239504PubMed
12,663,800Varicella-zoster virus productively infects mature dendritic cells and alters their immune function.J Virol2003https://conductscience.org/library/papers/12663800PubMed
12,595,432
Trypanosoma cruzi infection modulates in vivo expression of major histocompatibility complex class II molecules on antigen-presenting cells and T-cell stimulatory activity of dendritic cells in a strain-dependent manner.
Infect Immun2003https://conductscience.org/library/papers/12595432PubMed
11,733,563High-affinity T helper epitope induces complementary helper and APC polarization, increased CTL, and protection against viral infection.J Clin Invest2001https://conductscience.org/library/papers/11733563PubMed
11,672,507HIV-1 infection of placental cord blood monocyte-derived dendritic cells.J Hematother Stem Cell Res2001https://conductscience.org/library/papers/11672507PubMed
11,422,197Mechanism of NK cell activation induced by coculture with dendritic cells derived from peripheral blood monocytes.Clin Exp Immunol2001https://conductscience.org/library/papers/11422197PubMed
11,067,871Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.J Exp Med2000https://conductscience.org/library/papers/11067871PubMed
11,021,596Poxvirus as a vector to transduce human dendritic cells for immunotherapy: abortive infection but reduced APC function.Gene Ther2000https://conductscience.org/library/papers/11021596PubMed
10,888,653Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity.J Virol2000https://conductscience.org/library/papers/10888653PubMed

See all 46 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD28940PubTator's text mininghttps://conductscience.org/library/genes/940NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
FCGR3A2,214PubTator's text mininghttps://conductscience.org/library/genes/2214NCBI Gene
IL2RA3,559PubTator's text mininghttps://conductscience.org/library/genes/3559NCBI Gene
ITGAM3,684PubTator's text mininghttps://conductscience.org/library/genes/3684NCBI Gene
PTPRC5,788PubTator's text mininghttps://conductscience.org/library/genes/5788NCBI Gene

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

None in this release

  • Trials
  • Comments and corrections
  • Drugs
  • Data

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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