ConductScience.org, home
Papers
API referenceFor AI assistants

Paper · 21397855

Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.

Chow LM and 8 others. Cancer Cell, 2011. Cited by 222 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Download JSON
Cite this record

ConductScience Library. Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain. Papers, record 21397855. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/21397855

On this page

Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Cooperativity within and among Pten, p53, and Rb pathways induces high-grade astrocytoma in adult brain.
PubMed
Journal
Cancer Cell
PubMed
Year
2011
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
222
iCite
Relative citation ratio, by iCite
4.78
iCite
Revised in PubMed
2025-05-29
PubMed

Authors9

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chow LMLionel M L
2Endersby RRaelene
3Zhu XXiaoyan
4Rankin SSherri
5Qu CChunxu
6Zhang JJunyuan
7Broniscer AAlberto
8Ellison DWDavid W
9Baker SJSuzanne J

Source PubMed

Topics25

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
AstrocytomaMajor topic
Brain NeoplasmsMajor topic
PTEN PhosphohydrolaseMajor topic
Retinoblastoma ProteinMajor topic
Signal TransductionMajor topic
Tumor Suppressor Protein p53Major topic
Animals
Blotting, Western
Brain
Female
Gene Amplification
Gene Expression Profiling
Glioblastoma
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Kaplan-Meier Estimate
Male
Mice
Mice, 129 Strain
Mice, Inbred C57BL
Mice, Knockout
Receptor Protein-Tyrosine Kinases
Reverse Transcriptase Polymerase Chain Reaction
Time Factors

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P01 CA096832NCI NIH HHSUnited StatesP01CA096832PubMed and NIHNIH RePORTER
R01 CA135554NCI NIH HHSUnited StatesR01CA135554PubMed and NIHNIH RePORTER
CA135554NCI NIH HHSUnited StatesR01CA135554PubMed and NIHNIH RePORTER
CA096832NCI NIH HHSUnited StatesP01CA096832PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Comment in21,397,851Glioma models: new GEMMs add "class" with genomic and expression correlations.https://conductscience.org/library/papers/21397851

Source PubMed

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
119,927,122Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.EMBO J2010https://conductscience.org/library/papers/19927122PubMed
212,004,004Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.Lab Invest2002https://conductscience.org/library/papers/12004004PubMed
311,371,355T cell-specific loss of Pten leads to defects in central and peripheral tolerance.Immunity2001https://conductscience.org/library/papers/11371355PubMed
417,618,441The 2007 WHO classification of tumours of the central nervous system.Acta Neuropathol2007https://conductscience.org/library/papers/17618441PubMed
518,451,155Pten haploinsufficiency accelerates formation of high-grade astrocytomas.Cancer Res2008https://conductscience.org/library/papers/18451155PubMed
619,544,474Astrocytes reverted to a neural progenitor-like state with transforming growth factor alpha are sensitized to cancerous transformation.Stem Cells2009https://conductscience.org/library/papers/19544474PubMed
711,726,926Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.Nat Genet2001https://conductscience.org/library/papers/11726926PubMed
815,172,977Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.Cancer Res2004https://conductscience.org/library/papers/15172977PubMed
911,095,732Identification of a multipotent astrocytic stem cell in the immature and adult mouse brain.Proc Natl Acad Sci U S A2000https://conductscience.org/library/papers/11095732PubMed
1016,530,701Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis.Cancer Cell2006https://conductscience.org/library/papers/16530701PubMed

1 to 10 of 49

See all 49 references

Cited by178

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 222 citations.

PMIDTitleJournalYearIn PapersSource
42,793,014Architects of Aggression: The Molecular Blueprint of Glioma Progression.Genes (Basel)2026https://conductscience.org/library/papers/42793014PubMed
42,768,016Metabolic licensing of quiescent glioblastoma activation and immune evasion via astrocyte-mitochondria shuttle.Nat Commun2026https://conductscience.org/library/papers/42768016PubMed
42,094,747Modeling genetic mosaicism of the mammalian target of rapamycin pathway in the cerebral cortex.Front Mamm Sci2023https://conductscience.org/library/papers/42094747PubMed
41,756,760Epigenetic maintenance of the injury response state in glioblastoma stem cells.Neurooncol Adv2026https://conductscience.org/library/papers/41756760PubMed
41,634,415Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.Nat Genet2026https://conductscience.org/library/papers/41634415PubMed
41,105,775Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup.Sci Adv2025https://conductscience.org/library/papers/41105775PubMed
40,781,177Graphene quantum dot-integrated nanocomposites: a promising avenue for glioblastoma treatment.Med Oncol2025https://conductscience.org/library/papers/40781177PubMed
40,597,933Sulforaphane induces cell morphology change and cell apoptosis by activating endoplasmic reticulum stress in glioblastoma.BMC Cancer2025https://conductscience.org/library/papers/40597933PubMed
40,429,889IGFBP-2 and IGF-II: Key Components of the Neural Stem Cell Niche? Implications for Glioblastoma Pathogenesis.Int J Mol Sci2025https://conductscience.org/library/papers/40429889PubMed
40,243,478Reactive Astrocytes in Glioma: Emerging Opportunities and Challenges.Int J Mol Sci2025https://conductscience.org/library/papers/40243478PubMed

1 to 10 of 178

See all 178 cited by

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CYCSP39342,358PubTator's text mininghttps://conductscience.org/library/genes/342358NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
IDH13,417PubTator's text mininghttps://conductscience.org/library/genes/3417NCBI Gene
NF14,763PubTator's text mininghttps://conductscience.org/library/genes/4763NCBI Gene
PDGFRA5,156PubTator's text mininghttps://conductscience.org/library/genes/5156NCBI Gene
PTEN5,728PubTator's text mininghttps://conductscience.org/library/genes/5728NCBI Gene
RB15,925PubTator's text mininghttps://conductscience.org/library/genes/5925NCBI Gene
SLTM79,811PubTator's text mininghttps://conductscience.org/library/genes/79811NCBI Gene
TP537,157PubTator's text mininghttps://conductscience.org/library/genes/7157NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE22927

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this paper from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/papers/v1/21397855

GET https://conductscience.org/api/papers/v1/21397855/references?page=2

API referenceFor AI assistants