Paper · 24744239
The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.
Mukherjee S and 3 others. Nucleic Acids Res, 2014. Cited by 17 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage. Papers, record 24744239. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/24744239
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
- Title
- The Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.
- PubMed
Topics8
NLM's MeSH indexing of the paper, its major topics first.
| MeSH term | Major |
|---|---|
| DNA | Major topic |
| DNA-Binding Proteins | Major topic |
| Endonucleases | Major topic |
| Flap Endonucleases | Major topic |
| Saccharomyces cerevisiae Proteins | Major topic |
| DNA Cleavage | |
| DNA, Cruciform | |
| Protein Conformation |
Source PubMed
Grants6
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| T32 GM007377 | NIGMS NIH HHS | United States | T32GM007377 | PubMed and NIH | NIH RePORTER |
| CA92276 | NCI NIH HHS | United States | R01CA092276 | PubMed and NIH | NIH RePORTER |
| R01 CA092276 | NCI NIH HHS | United States | R01CA092276 | PubMed and NIH | NIH RePORTER |
| GM58015 | NIGMS NIH HHS | United States | R01GM058015 | PubMed and NIH | NIH RePORTER |
| R01 GM058015 | NIGMS NIH HHS | United States | R01GM058015 | PubMed and NIH | NIH RePORTER |
| T32 GM099608 | NIGMS NIH HHS | United States | T32GM099608 | PubMed and NIH | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections0
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
None in this release.
References56
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 22,730,299 | Cell cycle-dependent regulation of the nuclease activity of Mus81-Eme1/Mms4. | Nucleic Acids Res | 2012 | https://conductscience.org/library/papers/22730299 | PubMed |
| 2 | 18,054,789 | Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. | J Mol Biol | 2008 | https://conductscience.org/library/papers/18054789 | PubMed |
| 3 | 20,178,992 | Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing. | J Biol Chem | 2010 | https://conductscience.org/library/papers/20178992 | PubMed |
| 4 | 22,123,861 | Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. | J Cell Biol | 2011 | https://conductscience.org/library/papers/22123861 | PubMed |
| 5 | 21,369,956 | Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes. | Chromosoma | 2011 | https://conductscience.org/library/papers/21369956 | PubMed |
| 6 | 21,496,641 | Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily. | Cell | 2011 | https://conductscience.org/library/papers/21496641 | PubMed |
| 7 | 21,496,637 | FEN nucleases: bind, bend, fray, cut. | Cell | 2011 | https://conductscience.org/library/papers/21496637 | PubMed |
| 8 | 21,660,704 | Assays for structure-selective DNA endonucleases. | Methods Mol Biol | 2011 | https://conductscience.org/library/papers/21660704 | PubMed |
| 9 | 11,139,495 | Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. | Genetics | 2001 | https://conductscience.org/library/papers/11139495 | PubMed |
| 10 | 17,174,892 | Single Holliday junctions are intermediates of meiotic recombination. | Cell | 2006 | https://conductscience.org/library/papers/17174892 | PubMed |
1 to 10 of 56
See all 56 referencesCited by13
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 17 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 38,832,625 | Concurrent D-loop cleavage by Mus81 and Yen1 yields half-crossover precursors. | Nucleic Acids Res | 2024 | https://conductscience.org/library/papers/38832625 | PubMed |
| 34,804,132 | Exploring the Structures and Functions of Macromolecular SLX4-Nuclease Complexes in Genome Stability. | Front Genet | 2021 | https://conductscience.org/library/papers/34804132 | PubMed |
| 33,967,572 | Making Choices: DNA Replication Fork Recovery Mechanisms. | Semin Cell Dev Biol | 2021 | https://conductscience.org/library/papers/33967572 | PubMed |
| 32,814,343 | PCNA activates the MutLγ endonuclease to promote meiotic crossing over. | Nature | 2020 | https://conductscience.org/library/papers/32814343 | PubMed |
| 30,652,106 | Guidelines for DNA recombination and repair studies: Mechanistic assays of DNA repair processes. | Microb Cell | 2019 | https://conductscience.org/library/papers/30652106 | PubMed |
| 30,590,761 | Resolution of the Holliday junction recombination intermediate by human GEN1 at the single-molecule level. | Nucleic Acids Res | 2019 | https://conductscience.org/library/papers/30590761 | PubMed |
| 28,969,641 | Role of PCNA and RFC in promoting Mus81-complex activity. | BMC Biol | 2017 | https://conductscience.org/library/papers/28969641 | PubMed |
| 28,453,523 | The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans. | PLoS Biol | 2017 | https://conductscience.org/library/papers/28453523 | PubMed |
| 28,257,701 | The SMX DNA Repair Tri-nuclease. | Mol Cell | 2017 | https://conductscience.org/library/papers/28257701 | PubMed |
| 26,686,657 | Roles for mismatch repair family proteins in promoting meiotic crossing over. | DNA Repair (Amst) | 2016 | https://conductscience.org/library/papers/26686657 | PubMed |
1 to 10 of 13
See all 13 cited byGenes9
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| CDC5L | 988 | PubTator's text mining | https://conductscience.org/library/genes/988 | NCBI Gene |
| CDS1 | 1,040 | PubTator's text mining | https://conductscience.org/library/genes/1040 | NCBI Gene |
| CHEK2 | 11,200 | PubTator's text mining | https://conductscience.org/library/genes/11200 | NCBI Gene |
| EME1 | 146,956 | PubTator's text mining | https://conductscience.org/library/genes/146956 | NCBI Gene |
| EXO1 | 9,156 | PubTator's text mining | https://conductscience.org/library/genes/9156 | NCBI Gene |
| FEN1 | 2,237 | PubTator's text mining | https://conductscience.org/library/genes/2237 | NCBI Gene |
| MUS81 | 80,198 | PubTator's text mining | https://conductscience.org/library/genes/80198 | NCBI Gene |
| PCNA | 5,111 | PubTator's text mining | https://conductscience.org/library/genes/5111 | NCBI Gene |
| SLX4 | 84,464 | PubTator's text mining | https://conductscience.org/library/genes/84464 | NCBI Gene |
Drugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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