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Paper · 25119024

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Viale A and 29 others. Nature, 2014. Cited by 1,097 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Papers, record 25119024. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/25119024

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
PubMed
Journal
Nature
PubMed
Year
2014
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
1,097
iCite
Relative citation ratio, by iCite
29.4
iCite
Revised in PubMed
2026-04-08
PubMed

Authors30

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Viale AAndrea
2Pettazzoni PPiergiorgio
3Lyssiotis CACostas A
4Ying HHaoqiang
5Sánchez NNora
6Marchesini MMatteo
7Carugo AAlessandro
8Green TTessa
9Seth SSahil
10Giuliani VVirginia

1 to 10 of 30Source PubMed

See all 30 authors

Topics21

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Carcinoma, Pancreatic DuctalMajor topic
MitochondriaMajor topic
Pancreatic NeoplasmsMajor topic
Proto-Oncogene Proteins p21(ras)Major topic
Animals
Autophagy
Cell Respiration
Cell Survival
Disease Models, Animal
Female
Gene Expression Regulation, Neoplastic
Genes, p53
Glycolysis
Lysosomes
Mice
Mutation
Neoplasm Recurrence, Local
Neoplastic Stem Cells
Oxidative Phosphorylation
Recurrence
Signal Transduction

Source PubMed

Grants10

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30CA16672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
P30 CA016672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
CA16672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
P01 CA117969NCI NIH HHSUnited StatesP01CA117969PubMed and NIHNIH RePORTER
P01CA117969NCI NIH HHSUnited StatesP01CA117969PubMed and NIHNIH RePORTER
P01CA120964NCI NIH HHSUnited StatesP01CA120964PubMed and NIHNIH RePORTER
P50 CA127003NCI NIH HHSUnited StatesP50CA127003PubMed and NIHNIH RePORTER
P01 CA120964NCI NIH HHSUnited StatesP01CA120964PubMed and NIHNIH RePORTER
CA016672NCI NIH HHSUnited StatesP01CA016672PubMed and NIHNIH RePORTER
P30CA016672NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in41,951,747Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.https://conductscience.org/library/papers/41951747PubMed
Comment in25,155,173Targeted therapy: Targeting mitochondria in pancreatic cancer.https://conductscience.org/library/papers/25155173PubMed

References29

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,994,921K-ras codon-specific mutations produce distinctive metabolic phenotypes in NIH3T3 mice [corrected] fibroblasts.Cancer Res2005https://conductscience.org/library/papers/15994921PubMed
220,818,844Inhibition of mutated, activated BRAF in metastatic melanoma.N Engl J Med2010https://conductscience.org/library/papers/20818844PubMed
319,876,027Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice.Nat Protoc2009https://conductscience.org/library/papers/19876027PubMed
419,652,654Imatinib and beyond--exploring the full potential of targeted therapy for CML.Nat Rev Clin Oncol2009https://conductscience.org/library/papers/19652654PubMed
521,847,114Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.Mol Syst Biol2011https://conductscience.org/library/papers/21847114PubMed
611,870,241Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia.N Engl J Med2002https://conductscience.org/library/papers/11870241PubMed
723,321,785P2Y1R-initiated, IP3R-dependent stimulation of astrocyte mitochondrial metabolism reduces and partially reverses ischemic neuronal damage in mouse.J Cereb Blood Flow Metab2013https://conductscience.org/library/papers/23321785PubMed
821,695,188ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma.PLoS One2011https://conductscience.org/library/papers/21695188PubMed
918,568,040Ras oncogenes: split personalities.Nat Rev Mol Cell Biol2008https://conductscience.org/library/papers/18568040PubMed
1019,339,967Autophagy regulates lipid metabolism.Nature2009https://conductscience.org/library/papers/19339967PubMed

1 to 10 of 29

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Cited by840

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,097 citations.

PMIDTitleJournalYearIn PapersSource
42,967,940Molecular and immune heterogeneity across limited-stage and extensive-stage small cell lung cancer.Exp Mol Med2026https://conductscience.org/library/papers/42967940PubMed
42,936,416NDUFS1 promotes malignant breast cancer behaviors through enhancement of mitochondrial respiration and PROX1/c-Myc signaling.iScience2026https://conductscience.org/library/papers/42936416PubMed
42,926,286Integrated Functional and Metabolomic Profiling of Melanoma Cells Treated with Redox-Active Compounds.Methods Mol Biol2027https://conductscience.org/library/papers/42926286PubMed
42,923,094Epigenetic adaptations and vulnerabilities in ovarian cancer drug-tolerant persister cells.NAR Cancer2026https://conductscience.org/library/papers/42923094PubMed
42,857,319Research progress of pancreatic cancer based on ferroptosis-cuproptosis interaction (Review).Oncol Lett2026https://conductscience.org/library/papers/42857319PubMed
42,818,236ALDH1B1 promotes mitochondrial γ-butyrobetaine biosynthesis and fatty acid oxidation in colorectal cancer.bioRxiv2026https://conductscience.org/library/papers/42818236PubMed
42,698,921Spatiotemporal control of mitoribosome-mediated metabolic reprogramming in cancer: implications for heterogeneity and therapeutic targeting.Front Cell Dev Biol2026https://conductscience.org/library/papers/42698921PubMed
42,669,625DLST Succinylation-Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma.Adv Sci (Weinh)2026https://conductscience.org/library/papers/42669625PubMed
42,666,728Autophagy inhibition in pancreatic cancer: hope or hype?Autophagy Rep2026https://conductscience.org/library/papers/42666728PubMed
42,653,862A Bioactivated Lepidium latifolium Formulation Disrupts Mitochondrial Bioenergetics and Metabolic Adaptation in KRAS-Mutant Cancer Cells.Molecules2026https://conductscience.org/library/papers/42653862PubMed

1 to 10 of 840

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ABCD1215PubTator's text mininghttps://conductscience.org/library/genes/215NCBI Gene
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
EIF2AK39,451PubTator's text mininghttps://conductscience.org/library/genes/9451NCBI Gene
HSP90AA13,320PubTator's text mininghttps://conductscience.org/library/genes/3320NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MAP2K75,609PubTator's text mininghttps://conductscience.org/library/genes/5609NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene
PIK3CD5,293PubTator's text mininghttps://conductscience.org/library/genes/5293NCBI Gene
POTEF728,378PubTator's text mininghttps://conductscience.org/library/genes/728378NCBI Gene

1 to 10 of 16

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data1

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccession
GEOGSE58307

Source GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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