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Paper · 26909576

Genomic analyses identify molecular subtypes of pancreatic cancer.

Bailey P and 102 others. Nature, 2016. Cited by 2,921 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Genomic analyses identify molecular subtypes of pancreatic cancer. Papers, record 26909576. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/26909576

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Genomic analyses identify molecular subtypes of pancreatic cancer.
PubMed
Journal
Nature
PubMed
Year
2016
PubMed
Publication types
Journal Article, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
2,921
iCite
Relative citation ratio, by iCite
92
iCite
Revised in PubMed
2026-08-12
PubMed

Authors103

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bailey PPeter
2Chang DKDavid K
3Nones KKatia
4Johns ALAmber L
5Patch AMAnn-Marie
6Gingras MCMarie-Claude
7Miller DKDavid K
8Christ ANAngelika N
9Bruxner TJTim J C
10Quinn MCMichael C

1 to 10 of 103Source PubMed

See all 103 authors

Topics31

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Genes, NeoplasmMajor topic
Genome, HumanMajor topic
GenomicsMajor topic
MutationMajor topic
Pancreatic NeoplasmsMajor topic
Animals
Basic Helix-Loop-Helix Proteins
Carcinoma, Pancreatic Ductal
Cell Line, Tumor
DNA Methylation
DNA-Binding Proteins
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Hepatocyte Nuclear Factor 3-beta
Hepatocyte Nuclear Factor 3-gamma
Histone Demethylases
Homeobox Protein Nkx-2.2
Homeodomain Proteins
Humans
Mice
Nuclear Proteins
Prognosis
Receptors, Cytoplasmic and Nuclear
Survival Analysis
Trans-Activators
Transcription Factors
Transcription, Genetic
Transcriptome
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Zebrafish Proteins

Source PubMed

Grants12

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
12946Cancer Research UKUnited KingdomPubMed
11650Cancer Research UKUnited KingdomPubMed
22533Cancer Research UKUnited KingdomPubMed
21139Cancer Research UKUnited KingdomPubMed
MR/N005813/1Medical Research CouncilUnited KingdomPubMed
C29717/A17263Cancer Research UKUnited KingdomPubMed
103721/Z/14/ZWellcome TrustUnited KingdomPubMed
A12481Cancer Research UKUnited KingdomPubMed
20409Cancer Research UKUnited KingdomPubMed
17263Cancer Research UKUnited KingdomPubMed

1 to 10 of 12Source PubMed

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Trials3

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT02704156SBRT Plus Pembrolizumab and Trametinib for Pancreatic CancerBackgroundClinicalTrials.gov
NCT04692740Chlorambucil in Metastatic PDAC Patients Bearing a Germ Line DNA Defects Repair Mutations (SALE Trial)BackgroundClinicalTrials.gov
NCT05556603AssesSment of Early-deteCtion basEd oN liquiD Biopsy in PANCEATIC Cancer (ASCEND-PANCREATIC)BackgroundClinicalTrials.gov

Comments and corrections2

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Comment in26,977,785Pancreatic cancer: A problem quartered--new subtypes, new solutions?https://conductscience.org/library/papers/26977785PubMed
Comment in38,984,425Defining and tracing subtypes of patient-derived xenograft models in pancreatic ductal adenocarcinoma.https://conductscience.org/library/papers/38984425PubMed

References50

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
122,529,374Mind bomb 1 is required for pancreatic β-cell formation.Proc Natl Acad Sci U S A2012https://conductscience.org/library/papers/22529374PubMed
221,321,214Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2+ breast cancer patients.Proc Natl Acad Sci U S A2011https://conductscience.org/library/papers/21321214PubMed
324,052,622Acquired mutations that affect pre-mRNA splicing in hematologic malignancies and solid tumors.J Natl Cancer Inst2013https://conductscience.org/library/papers/24052622PubMed
419,910,308edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.Bioinformatics2010https://conductscience.org/library/papers/19910308PubMed
518,551,415Using GenePattern for gene expression analysis.Curr Protoc Bioinformatics2008https://conductscience.org/library/papers/18551415PubMed
621,816,040RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome.BMC Bioinformatics2011https://conductscience.org/library/papers/21816040PubMed
716,126,192The homeodomain protein PDX1 is required at mid-pancreatic development for the formation of the exocrine pancreas.Dev Biol2005https://conductscience.org/library/papers/16126192PubMed
824,113,773Inferring tumour purity and stromal and immune cell admixture from expression data.Nat Commun2013https://conductscience.org/library/papers/24113773PubMed
922,156,295Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.Genome Res2012https://conductscience.org/library/papers/22156295PubMed
1021,460,848Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy.Nat Med2011https://conductscience.org/library/papers/21460848PubMed

1 to 10 of 50

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Cited by2,192

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,921 citations.

PMIDTitleJournalYearIn PapersSource
42,979,207Liver-Lung Organotropism in Pancreatic Ductal Adenocarcinoma: A Five-Stage Framework.Cancer Manag Res2026https://conductscience.org/library/papers/42979207PubMed
42,978,795Machine learning models integrating 2D and 3D intratumoral heterogeneity features from multi-sequence MRI: accurate prediction of perineural invasion in pancreatic ductal adenocarcinoma.Front Artif Intell2026https://conductscience.org/library/papers/42978795PubMed
42,942,302BIMS-GA: Adaptive Multi-Objective Optimization for Network-Aware Pancreatic Ductal Adenocarcinoma Biomarker Discovery.Life (Basel)2026https://conductscience.org/library/papers/42942302PubMed
42,940,093Prognostic and Spatial Organization of Tertiary Lymphoid Structures in Pancreatic Ductal Adenocarcinoma.Biomedicines2026https://conductscience.org/library/papers/42940093PubMed
42,938,942Context-Dependent Spatial and Functional Roles of CD44 Across Pancreatic Ductal Adenocarcinoma States.Cancers (Basel)2026https://conductscience.org/library/papers/42938942PubMed
42,938,908The Evolution of Oligometastatic Pancreatic Ductal Adenocarcinoma: From Anatomic Description to Biologically Informed Patient Selection.Cancers (Basel)2026https://conductscience.org/library/papers/42938908PubMed
42,935,847Treating a systemic disease as a local one: failure points of current pancreatic cancer management and a multimodal, biology-guided framework for redesign.Front Oncol2026https://conductscience.org/library/papers/42935847PubMed
42,922,762Paternal regulation of H3K4 methylation supports tumor suppressor networks in mammals intergenerationally.bioRxiv2026https://conductscience.org/library/papers/42922762PubMed
42,898,383A MYC-LDHA-MCT4 expression program marks an SPP1/TREM2-centered macrophage state in pancreatic ductal adenocarcinoma.Front Immunol2026https://conductscience.org/library/papers/42898383PubMed
42,890,651Transcription factor-driven metabolic stratification reveals glycolytic and lipogenic subtypes with distinct prognostic and functional features in pancreatic cancer.Front Oncol2026https://conductscience.org/library/papers/42890651PubMed

1 to 10 of 2,192

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Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
FOXA23,170PubTator's text mininghttps://conductscience.org/library/genes/3170NCBI Gene
FOXA33,171PubTator's text mininghttps://conductscience.org/library/genes/3171NCBI Gene
KDM6A7,403PubTator's text mininghttps://conductscience.org/library/genes/7403NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MNX13,110PubTator's text mininghttps://conductscience.org/library/genes/3110NCBI Gene
NEUROD14,760PubTator's text mininghttps://conductscience.org/library/genes/4760NCBI Gene
NKX2-24,821PubTator's text mininghttps://conductscience.org/library/genes/4821NCBI Gene
NR5A22,494PubTator's text mininghttps://conductscience.org/library/genes/2494NCBI Gene
PDX13,651PubTator's text mininghttps://conductscience.org/library/genes/3651NCBI Gene
RBPJL11,317PubTator's text mininghttps://conductscience.org/library/genes/11317NCBI Gene

1 to 10 of 13

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data2

The data bank entries PubMed's record names. Trial numbers are under Trials.

Data bankAccessionSource
GEOGSE36924GEO
GEOGSE49149GEO

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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