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Paper · 29567829

The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.

Pushalkar S and 32 others. Cancer Discov, 2018. Cited by 1,177 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Papers, record 29567829. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29567829

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.
PubMed
Journal
Cancer Discov
PubMed
Year
2018
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
Citations, by iCite
1,177
iCite
Relative citation ratio, by iCite
40.4
iCite
Revised in PubMed
2025-05-29
PubMed

Authors33

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Pushalkar SSmruti
2Hundeyin MMautin
3Daley DDonnele
4Zambirinis CPConstantinos P
5Kurz EEmma
6Mishra AAnkita
7Mohan NNavyatha
8Aykut BBerk
9Usyk MMykhaylo
10Torres LELuisana E

1 to 10 of 33Source PubMed

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Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CarcinogenesisMajor topic
MicrobiotaMajor topic
MonocytesMajor topic
Pancreatic NeoplasmsMajor topic
Toll-Like ReceptorsMajor topic
Animals
Bacteria
Cell Differentiation
Female
Humans
Male
Mice
Signal Transduction

Source PubMed

Grants11

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA180277NCI NIH HHSUnited StatesR01CA180277PubMed and NIHNIH RePORTER
UL1 TR001445NCATS NIH HHSUnited StatesUL1TR001445PubMed and NIHNIH RePORTER
P30 CA016087NCI NIH HHSUnited StatesP30CA016087PubMedNIH RePORTER
P40 OD010995NIH HHSUnited StatesP40OD010995PubMed and NIHNIH RePORTER
P30 DK034987NIDDK NIH HHSUnited StatesP30DK034987PubMedNIH RePORTER
R21 CA175794NCI NIH HHSUnited StatesR21CA175794PubMed and NIHNIH RePORTER
R21 CA155649NCI NIH HHSUnited StatesR21CA155649PubMedNIH RePORTER
R01 CA206105NCI NIH HHSUnited StatesR01CA206105PubMed and NIHNIH RePORTER
R01 DE025992NIDCR NIH HHSUnited StatesR01DE025992PubMed and NIHNIH RePORTER
T32 GM007308NIGMS NIH HHSUnited StatesT32GM007308PubMed and NIHNIH RePORTER

1 to 10 of 11

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Trials3

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

TrialTitleThe trial lists it asNamed in the paper's recordSource
NCT07818421Intratumoral Microbiota and Immune Microenvironment in Prostate CancerResultsClinicalTrials.gov
NCT07845565FMT Plus SHR-1701 With Nab-Paclitaxel/Gemcitabine as First-Line Treatment for Locally Advanced or Metastatic Pancreatic Ductal AdenocarcinomaBackgroundClinicalTrials.gov
NCT07854977Fecal Microbiota Transplantation Combined With NALIRIFOX Plus Serplulimab as First-line Treatment for Advanced or Metastatic Pancreatic Ductal Adenocarcinoma.BackgroundClinicalTrials.gov

Comments and corrections4

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn PapersSource
Erratum in33,262,184Correction: The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression.https://conductscience.org/library/papers/33262184PubMed
Comment in29,610,286Immunotherapy for Pancreatic Cancer: More Than Just a Gut Feeling.https://conductscience.org/library/papers/29610286PubMed
Comment in29,674,642Microbiome promotes pancreatic cancer.https://conductscience.org/library/papers/29674642PubMed
Comment in30,613,638Microbial marauders: pancreatic microbiota and its impact on carcinogenesis.https://conductscience.org/library/papers/30613638PubMed

References54

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
121,702,898Metagenomic biomarker discovery and explanation.Genome Biol2011https://conductscience.org/library/papers/21702898PubMed
215,184,435Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora.J Clin Microbiol2004https://conductscience.org/library/papers/15184435PubMed
324,060,131Advancing our understanding of the human microbiome using QIIME.Methods Enzymol2013https://conductscience.org/library/papers/24060131PubMed
424,675,436The gut microbiome in health and disease.Gastroenterology2014https://conductscience.org/library/papers/24675436PubMed
511,474,100Complex species interactions and the dynamics of ecological systems: long-term experiments.Science2001https://conductscience.org/library/papers/11474100PubMed
626,066,790In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA.J Vis Exp2015https://conductscience.org/library/papers/26066790PubMed
717,909,062Dynamics of the immune reaction to pancreatic cancer from inception to invasion.Cancer Res2007https://conductscience.org/library/papers/17909062PubMed
812,732,560Protocol for rapid fluorescence in situ hybridization of bacteria in cryosections of microarthropods.Appl Environ Microbiol2003https://conductscience.org/library/papers/12732560PubMed
928,442,553NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma.J Exp Med2017https://conductscience.org/library/papers/28442553PubMed
1017,000,676Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.Clin Cancer Res2006https://conductscience.org/library/papers/17000676PubMed

1 to 10 of 54

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Cited by936

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 1,177 citations.

PMIDTitleJournalYearIn PapersSource
42,979,040Naringenin in pancreatic cancer: emerging evidence on the tumor immune-stromal microenvironment, immunometabolic reprogramming, microbiota-host crosstalk, and therapeutic resistance.Front Immunol2026https://conductscience.org/library/papers/42979040PubMed
42,967,594The microbiome and brain metastasis in non-small cell lung cancer: A graded appraisal and a framework for prevention-oriented research.Clin Transl Med2026https://conductscience.org/library/papers/42967594PubMed
42,957,626Autophagy and intratumoral bacteria abundance influence the prognosis of patients with pancreatic carcinoma.Cell Death Dis2026https://conductscience.org/library/papers/42957626PubMed
42,941,196Gut Microbiome Compositional and Functional Signatures Associated with Chemotherapy Response in Pancreatic Ductal Adenocarcinoma: An Exploratory Cohort Study.Metabolites2026https://conductscience.org/library/papers/42941196PubMed
42,909,229Gut mycobiome dysbiosis in digestive system cancers: immune remodeling and translational implications.Front Cell Infect Microbiol2026https://conductscience.org/library/papers/42909229PubMed
42,903,966Interactions between microbiota and innate immunity in tumor microenvironment: Novel insights into cancer progression and immunotherapy.Hlife2025https://conductscience.org/library/papers/42903966PubMed
42,903,607The intratumoral microbiome in breast cancer: an actionable component of the tumor immune microenvironment.Front Immunol2026https://conductscience.org/library/papers/42903607PubMed
42,898,931Spatial organization of intratumoral microbiome and regional tumor immunity.Front Immunol2026https://conductscience.org/library/papers/42898931PubMed
42,898,724Intratumoral microbiota and their emerging role in the tumor microenvironment.Microbiome Res Rep2026https://conductscience.org/library/papers/42898724PubMed
42,891,339Microbiome-pancreatic cancer crosstalk: From tumor biology to therapeutic intervention.IMetaOmics2026https://conductscience.org/library/papers/42891339PubMed

1 to 10 of 936

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Genes10

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CD38952PubTator's text mininghttps://conductscience.org/library/genes/952NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
CD8A925PubTator's text mininghttps://conductscience.org/library/genes/925NCBI Gene
FCGR2A2,212PubTator's text mininghttps://conductscience.org/library/genes/2212NCBI Gene
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene
ITGAM3,684PubTator's text mininghttps://conductscience.org/library/genes/3684NCBI Gene
PDCD15,133PubTator's text mininghttps://conductscience.org/library/genes/5133NCBI Gene
TLR57,100PubTator's text mininghttps://conductscience.org/library/genes/7100NCBI Gene
TLR751,284PubTator's text mininghttps://conductscience.org/library/genes/51284NCBI Gene
TNF7,124PubTator's text mininghttps://conductscience.org/library/genes/7124NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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