Paper · 29643418
Contextual determinants of TGFβ action in development, immunity and cancer.
David CJ and 1 other. Nat Rev Mol Cell Biol, 2018. Cited by 701 papers, by iCite.
11 sourcespapers-2026-11-12-0.1.0
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ConductScience Library. Contextual determinants of TGFβ action in development, immunity and cancer. Papers, record 29643418. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/29643418
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Paper
PubMed's record of the paper, with iCite's citation figures. No abstract is shown.
Topics0
NLM's MeSH indexing of the paper, its major topics first.
None in this release.
Grants3
Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.
| Grant, as the record writes it | Agency | Country | NIH project | Stated by | Source |
|---|---|---|---|---|---|
| P30 CA008748 | NCI NIH HHS | United States | P30CA008748 | PubMed | NIH RePORTER |
| R01 CA034610 | NCI NIH HHS | United States | R01CA034610 | PubMed | NIH RePORTER |
| T32 CA160001 | NCI NIH HHS | United States | T32CA160001 | PubMed | NIH RePORTER |
Trials0
The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.
None in this release.
Comments and corrections1
PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.
| Kind | PMID | Title | In Papers |
|---|---|---|---|
| Erratum in | 29,740,128 | Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer. | https://conductscience.org/library/papers/29740128 |
Source PubMed
References195
The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.
| Order | PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|---|
| 1 | 28,191,871 | Distinct modes of SMAD2 chromatin binding and remodeling shape the transcriptional response to NODAL/Activin signaling. | Elife | 2017 | https://conductscience.org/library/papers/28191871 | PubMed |
| 2 | 18,684,741 | Dlx3 is a crucial regulator of hair follicle differentiation and cycling. | Development | 2008 | https://conductscience.org/library/papers/18684741 | PubMed |
| 3 | 28,741,478 | Targeting the Microenvironment in Advanced Colorectal Cancer. | Trends Cancer | 2016 | https://conductscience.org/library/papers/28741478 | PubMed |
| 4 | 9,214,508 | A structural basis for mutational inactivation of the tumour suppressor Smad4. | Nature | 1997 | https://conductscience.org/library/papers/9214508 | PubMed |
| 5 | 27,741,240 | Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate. | PLoS Genet | 2016 | https://conductscience.org/library/papers/27741240 | PubMed |
| 6 | 17,936,557 | Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. | Cancer Cell | 2007 | https://conductscience.org/library/papers/17936557 | PubMed |
| 7 | 29,140,250 | Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. | Elife | 2017 | https://conductscience.org/library/papers/29140250 | PubMed |
| 8 | 22,224,781 | Regulatory T cells: mechanisms of differentiation and function. | Annu Rev Immunol | 2012 | https://conductscience.org/library/papers/22224781 | PubMed |
| 9 | 12,105,419 | Metastasis is driven by sequential elevation of H-ras and Smad2 levels. | Nat Cell Biol | 2002 | https://conductscience.org/library/papers/12105419 | PubMed |
| 10 | 21,297,990 | Interaction of TGFβ and BMP signaling pathways during chondrogenesis. | PLoS One | 2011 | https://conductscience.org/library/papers/21297990 | PubMed |
1 to 10 of 195
See all 195 referencesCited by543
The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 701 citations.
| PMID | Title | Journal | Year | In Papers | Source |
|---|---|---|---|---|---|
| 42,982,877 | Deubiquitinases at the crossroads of T-cell immunity and tumor immune evasion. | Cell Mol Immunol | 2026 | https://conductscience.org/library/papers/42982877 | PubMed |
| 42,938,108 | Non-Invasive Assessment of SMAD4 Expression Status in Pancreatic Ductal Adenocarcinoma: Diagnostic Value of T1ρ-Weighted Imaging Combined with Clinical Parameters. | Diagnostics (Basel) | 2026 | https://conductscience.org/library/papers/42938108 | PubMed |
| 42,935,956 | The CXCL12/CXCR4 axis in breast cancer-associated fibroblasts: a transcriptome analysis and systematic literature review. | Front Bioeng Biotechnol | 2026 | https://conductscience.org/library/papers/42935956 | PubMed |
| 42,919,442 | Oncogenic RAS as an adaptive signaling ecosystem: context-dependent vulnerabilities and resistance-informed therapeutic design. | Exp Hematol Oncol | 2026 | https://conductscience.org/library/papers/42919442 | PubMed |
| 42,872,025 | FKBP12 determines ligand-specific SMAD signaling in individual living endothelial cells. | iScience | 2026 | https://conductscience.org/library/papers/42872025 | PubMed |
| 42,772,945 | SAE1 knockdown attenuates hepatic fibrosis by promoting ubiquitination and proteasomal degradation of TGF-β receptors. | BMJ Open Gastroenterol | 2026 | https://conductscience.org/library/papers/42772945 | PubMed |
| 42,709,540 | Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer. | Cancer Biol Ther | 2026 | https://conductscience.org/library/papers/42709540 | PubMed |
| 42,699,358 | Monocyte-Macrophage Lineages in Cancer: Biology, Plasticity, and Therapeutic Targeting. | Cancer Biome Target Ther | 2026 | https://conductscience.org/library/papers/42699358 | PubMed |
| 42,676,718 | Smad4 and Eomes converge on a shared transcriptional program associated with inflammatory CD8 T-cell differentiation. | Front Immunol | 2026 | https://conductscience.org/library/papers/42676718 | PubMed |
| 42,643,841 | NAD+ metabolism influences TGF-β-associated transcriptional programs and the gut microbiota in murine models of colitis. | Biochem Biophys Rep | 2026 | https://conductscience.org/library/papers/42643841 | PubMed |
1 to 10 of 543
See all 543 cited byGenes40
The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.
| Gene | NCBI Gene ID | Linked by | In Genes | Source |
|---|---|---|---|---|
| ACTR1B | 10,120 | PubTator's text mining | https://conductscience.org/library/genes/10120 | NCBI Gene |
| ACTR2 | 10,097 | PubTator's text mining | https://conductscience.org/library/genes/10097 | NCBI Gene |
| ACVR1 | 90 | PubTator's text mining | https://conductscience.org/library/genes/90 | NCBI Gene |
| ACVR1B | 91 | PubTator's text mining | https://conductscience.org/library/genes/91 | NCBI Gene |
| ACVR1C | 130,399 | PubTator's text mining | https://conductscience.org/library/genes/130399 | NCBI Gene |
| ACVR2A | 92 | PubTator's text mining | https://conductscience.org/library/genes/92 | NCBI Gene |
| ACVR2B | 93 | PubTator's text mining | https://conductscience.org/library/genes/93 | NCBI Gene |
| ACVRL1 | 94 | PubTator's text mining | https://conductscience.org/library/genes/94 | NCBI Gene |
| AMH | 268 | PubTator's text mining | https://conductscience.org/library/genes/268 | NCBI Gene |
| AMHR2 | 269 | PubTator's text mining | https://conductscience.org/library/genes/269 | NCBI Gene |
1 to 10 of 40
See all 40 genesDrugs0
The drugs whose trials, in the Pipelines release, list the paper.
None in this release.
Data0
The data bank entries PubMed's record names. Trial numbers are under Trials.
None in this release.
Data dates
The date of each source this release read.
- Trials
- 2026-11-12
- Gene search
- 2026-11-11
- Pipelines
- 2026-09-18
Sources 11
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- HGNCCC0
- iCiteCC BY 4.0
- NCBI GenePublic domain (US government)
- NIH RePORTER's grant and paper linksPublic domain
- Open TargetsCC0 1.0
- PMC's ID filePublic domain (US government)
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- HGNCCC0: https://www.genenames.org/about/license/
- iCiteCC BY 4.0
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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