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Paper · 30745814

A Pilot Study of Aberrant CpG Island Hypermethylation of SPRED1 in Acute Myeloloid Leukemia.

Sun J and 4 others. Int J Med Sci, 2019. Cited by 8 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. A Pilot Study of Aberrant CpG Island Hypermethylation of SPRED1 in Acute Myeloloid Leukemia. Papers, record 30745814. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/30745814

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
A Pilot Study of Aberrant CpG Island Hypermethylation of SPRED1 in Acute Myeloloid Leukemia.
PubMed
Journal
Int J Med Sci
PubMed
Year
2019
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
8
iCite
Relative citation ratio, by iCite
0.35
iCite
Revised in PubMed
2020-12-09
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Sun JJingwen
2Zhang JJinjing
3Wang YYue
4Li YYan
5Zhang RRui

Source PubMed

Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Intracellular Signaling Peptides and ProteinsMajor topic
Leukemia, Myeloid, AcuteMajor topic
Membrane ProteinsMajor topic
Adaptor Proteins, Signal Transducing
Adolescent
Adult
Aged
CpG Islands
DNA Methylation
Epigenesis, Genetic
Female
Humans
Male
Middle Aged
Pilot Projects
Young Adult

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References32

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,493,923Spred is a Sprouty-related suppressor of Ras signalling.Nature2001https://conductscience.org/library/papers/11493923PubMed
212,154,405CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future.Oncogene2002https://conductscience.org/library/papers/12154405PubMed
312,646,235Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.Biochem Biophys Res Commun2003https://conductscience.org/library/papers/12646235PubMed
414,744,114GeneNote: whole genome expression profiles in normal human tissues.C R Biol2003https://conductscience.org/library/papers/14744114PubMed
514,981,116Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation.J Exp Med2004https://conductscience.org/library/papers/14981116PubMed
615,388,519Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification.Bioinformatics2005https://conductscience.org/library/papers/15388519PubMed
715,952,895Eukaryotic cytosine methyltransferases.Annu Rev Biochem2005https://conductscience.org/library/papers/15952895PubMed
816,243,968Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.Proc Natl Acad Sci U S A2005https://conductscience.org/library/papers/16243968PubMed
916,319,681C/EBPalpha and the pathophysiology of acute myeloid leukemia.Curr Opin Hematol2006https://conductscience.org/library/papers/16319681PubMed
1016,652,141Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors.Oncogene2006https://conductscience.org/library/papers/16652141PubMed

1 to 10 of 32

See all 32 references

Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 8 citations.

PMIDTitleJournalYearIn PapersSource
41,094,606The role of SPRED1 mutation in melanoma.Eur J Med Res2025https://conductscience.org/library/papers/41094606PubMed
38,391,903Conditional Ablation of Spred1 and Spred2 in the Eye Lens Negatively Impacts Its Development and Growth.Cells2024https://conductscience.org/library/papers/38391903PubMed
35,359,401Methylation of SPRED1: A New Target in Acute Myeloid Leukemia.Front Oncol2022https://conductscience.org/library/papers/35359401PubMed
34,325,699Diagnostic difficulties and possibilities of NF1-like syndromes in childhood.BMC Pediatr2021https://conductscience.org/library/papers/34325699PubMed
33,427,197Use of signals of positive and negative selection to distinguish cancer genes and passenger genes.Elife2021https://conductscience.org/library/papers/33427197PubMed
32,851,895Progress in experimental research on SPRED protein family.J Int Med Res2020https://conductscience.org/library/papers/32851895PubMed
30,874,331The Sprouty/Spred family as tumor suppressors: Coming of age.Cancer Sci2019https://conductscience.org/library/papers/30874331PubMed

Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CEBPA1,050PubTator's text mininghttps://conductscience.org/library/genes/1050NCBI Gene
DNMT3A1,788PubTator's text mininghttps://conductscience.org/library/genes/1788NCBI Gene
FLT32,322PubTator's text mininghttps://conductscience.org/library/genes/2322NCBI Gene
IDH13,417PubTator's text mininghttps://conductscience.org/library/genes/3417NCBI Gene
IDH23,418PubTator's text mininghttps://conductscience.org/library/genes/3418NCBI Gene
KIT3,815PubTator's text mininghttps://conductscience.org/library/genes/3815NCBI Gene
KRAS3,845PubTator's text mininghttps://conductscience.org/library/genes/3845NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene
NF14,763PubTator's text mininghttps://conductscience.org/library/genes/4763NCBI Gene
NPM14,869PubTator's text mininghttps://conductscience.org/library/genes/4869NCBI Gene

1 to 10 of 16

See all 16 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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