Paper · 32150819

Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus.

Rachdaoui N. Int J Mol Sci, 2020. Cited by 162 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus. Papers, record 32150819. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32150819

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus.; PubMed
Journal: Int J Mol Sci; PubMed
Year: 2020; PubMed
Publication types: Journal Article, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/32150819/; PubMed
DOI: https://doi.org/10.3390/ijms21051770; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC7084909/; PubMed
The journal: https://conductscience.org/library/journal-index/101092791; PubMed
Citations, by iCite: 162; iCite
Relative citation ratio, by iCite: 9.7; iCite
Revised in PubMed: 2020-12-01; PubMed

Authors1

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename	Kind	ORCID iD
1	Rachdaoui N	Nadia

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Diabetes Mellitus, Type 2	Major topic
Hypoglycemic Agents	Major topic
Insulin	Major topic
Insulin Resistance	Major topic
Animals
Homeostasis
Humans

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by
5-2008-310	JDRF	United States		PubMed
502-05	Diabetes Association of Greater Cleveland			PubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References195

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	23,613,085	Insulin resistance in type 1 diabetes: what is 'double diabetes' and what are the risks?	Diabetologia	2013	https://conductscience.org/library/papers/23613085	PubMed
2	11,897,712	Increased islet cell proliferation, decreased apoptosis, and greater vascularization leading to beta-cell hyperplasia in mutant mice lacking insulin.	Endocrinology	2002	https://conductscience.org/library/papers/11897712	PubMed
3	2,642,434	Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion.	Diabetes	1989	https://conductscience.org/library/papers/2642434	PubMed
4	15,467,829	Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes.	J Clin Invest	2004	https://conductscience.org/library/papers/15467829	PubMed
5	15,467,831	Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells.	J Clin Invest	2004	https://conductscience.org/library/papers/15467831	PubMed
6	24,384,568	Insulin receptor signaling in normal and insulin-resistant states.	Cold Spring Harb Perspect Biol	2014	https://conductscience.org/library/papers/24384568	PubMed
7	5,543,636	Evidence for a feedback inhibition of insulin on insulin secretion in the isolated, perfused canine pancreas.	Diabetes	1971	https://conductscience.org/library/papers/5543636	PubMed
8	9,202,395	Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.	Mol Cell Endocrinol	1997	https://conductscience.org/library/papers/9202395	PubMed
9	15,551,269	Insulin and its receptor: structure, function and evolution.	Bioessays	2004	https://conductscience.org/library/papers/15551269	PubMed
10	7,040,963	Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity.	N Engl J Med	1982	https://conductscience.org/library/papers/7040963	PubMed

1 to 10 of 195

See all 195 references

Cited by110

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 162 citations.

PMID	Title	Journal	Year	In Papers	Source
42,958,671	Jiangtang Xiaozhi formula alleviates type 2 diabetes mellitus by improving islet beta-cell dedifferentiation: a network pharmacology-based study.	J Tradit Chin Med	2026	https://conductscience.org/library/papers/42958671	PubMed
42,727,018	Insulin Prescribing Challenges and Physician-Suggested Interventions: Evidence From a Tertiary Care Hospital in Lahore, Pakistan.	Endocrinol Diabetes Metab	2026	https://conductscience.org/library/papers/42727018	PubMed
42,534,817	IGFBP-1 is associated with IRS signaling upregulation and contributes to metabolic recovery post-Roux-en-Y bypass.	Front Endocrinol (Lausanne)	2026	https://conductscience.org/library/papers/42534817	PubMed
42,520,203	Trends in type 2 diabetes, prediabetes, and hyperglycemic recognition among menopausal women: A 20-year analysis of sociodemographic disparities.	Womens Health (Lond)	2026	https://conductscience.org/library/papers/42520203	PubMed
42,500,235	Glycemic and lipid responses to selenium-enriched vs. zeaxanthin-enriched eggs in patients with type 2 diabetes: a 12-week randomized controlled trial.	Front Nutr	2026	https://conductscience.org/library/papers/42500235	PubMed
42,253,926	Targeting Mitochondria in Aging-Related Diseases: Therapeutic Potential and Obstacles.	MedComm (2020)	2026	https://conductscience.org/library/papers/42253926	PubMed
42,131,482	Bioactive compounds as therapeutic modulators of metabolic syndrome: targeting inflammation and gut microbiota regulation.	Front Physiol	2026	https://conductscience.org/library/papers/42131482	PubMed
42,121,431	A Novel Peptide Derived from Sea Buckthorn Leaves: Enzymatic Preparation, Dual Inhibitory Activity Against α-Glucosidase and DPP-IV, and Its Molecular Mechanism.	Foods	2026	https://conductscience.org/library/papers/42121431	PubMed
42,052,977	Allostatic Load of Glucose Homeostasis, Epigenetic Biomarkers, and All-Cause and Cardiovascular Death: A Prospective Cohort Study.	J Am Heart Assoc	2026	https://conductscience.org/library/papers/42052977	PubMed
41,964,775	Pheophytin a from Microcystis aeruginosa exerts antidiabetic activity in streptozotocin-induced diabetes in rat model.	AMB Express	2026	https://conductscience.org/library/papers/41964775	PubMed

1 to 10 of 110

See all 110 cited by

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
AKT1	207	PubTator's text mining	https://conductscience.org/library/genes/207	NCBI Gene
FOXO1	2,308	PubTator's text mining	https://conductscience.org/library/genes/2308	NCBI Gene
GLP1R	2,740	PubTator's text mining	https://conductscience.org/library/genes/2740	NCBI Gene
IGF1	3,479	PubTator's text mining	https://conductscience.org/library/genes/3479	NCBI Gene
IGF2	3,481	PubTator's text mining	https://conductscience.org/library/genes/3481	NCBI Gene
INS	3,630	PubTator's text mining	https://conductscience.org/library/genes/3630	NCBI Gene
INSR	3,643	PubTator's text mining	https://conductscience.org/library/genes/3643	NCBI Gene
MTOR	2,475	PubTator's text mining	https://conductscience.org/library/genes/2475	NCBI Gene
PRL	5,617	PubTator's text mining	https://conductscience.org/library/genes/5617	NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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