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Paper · 32901017

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.

Yang W and 15 others. Nat Commun, 2020. Cited by 901 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity. Papers, record 32901017. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/32901017

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity.
PubMed
Journal
Nat Commun
PubMed
Year
2020
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
901
iCite
Relative citation ratio, by iCite
44.1
iCite
Revised in PubMed
2026-01-27
PubMed

Authors16

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Yang WWenjing
2Yu TTianming
3Huang XXiangsheng
4Bilotta AJAnthony J
5Xu LLeiqi
6Lu YYao
7Sun JJiaren
8Pan FFan
9Zhou JJiahttps://orcid.org/0000-0002-2811-1090
10Zhang WWenbo

1 to 10 of 16Source PubMed

See all 16 authors

Topics23

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Fatty Acids, VolatileMajor topic
Gastrointestinal MicrobiomeMajor topic
Immunity, InnateMajor topic
InterleukinsMajor topic
Animals
Butyrates
CD4-Positive T-Lymphocytes
Citrobacter rodentium
Colitis
Enterobacteriaceae Infections
Histone Deacetylase Inhibitors
Humans
Hypoxia-Inducible Factor 1, alpha Subunit
In Vitro Techniques
Lymphocytes
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Transgenic
Promoter Regions, Genetic
Receptors, Aryl Hydrocarbon
Receptors, G-Protein-Coupled
Interleukin-22

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 DK105585NIDDK NIH HHSUnited StatesR01DK105585PubMed and NIHNIH RePORTER
R01 DK112436NIDDK NIH HHSUnited StatesR01DK112436PubMed and NIHNIH RePORTER
R01 DK125011NIDDK NIH HHSUnited StatesR01DK125011PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References57

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
115,120,651IL-22, a Th1 cytokine that targets the pancreas and select other peripheral tissues.Int Immunopharmacol2004https://conductscience.org/library/papers/15120651PubMed
216,982,811Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides.J Exp Med2006https://conductscience.org/library/papers/16982811PubMed
331,022,687IL-22: There Is a Gap in Our Knowledge.Immunohorizons2018https://conductscience.org/library/papers/31022687PubMed
430,995,504IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation.Immunity2019https://conductscience.org/library/papers/30995504PubMed
523,200,827Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria.Immunity2012https://conductscience.org/library/papers/23200827PubMed
625,706,098Interleukin-22: immunobiology and pathology.Annu Rev Immunol2015https://conductscience.org/library/papers/25706098PubMed
722,359,410Healing of intestinal inflammation by IL-22.Inflamm Bowel Dis2012https://conductscience.org/library/papers/22359410PubMed
819,100,701Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.Immunity2008https://conductscience.org/library/papers/19100701PubMed
922,291,094Microbiota-induced IL-1β, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine.J Exp Med2012https://conductscience.org/library/papers/22291094PubMed
1019,029,903RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells.Nat Immunol2009https://conductscience.org/library/papers/19029903PubMed

1 to 10 of 57

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Cited by671

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 901 citations.

PMIDTitleJournalYearIn PapersSource
42,974,449Microbial metabolites in tumor epigenetic regulation.Imeta2026https://conductscience.org/library/papers/42974449PubMed
42,959,646Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management.MedComm (2020)2026https://conductscience.org/library/papers/42959646PubMed
42,947,379The Emerging Role of Butyrate in Immune Tolerance.J Immunol Res2026https://conductscience.org/library/papers/42947379PubMed
42,934,798Faecalibacterium prausnitzii in the gut protects against acute lung injury in influenza through butyrate educated reparative CD4+T cells.Microbiome2026https://conductscience.org/library/papers/42934798PubMed
42,925,396Clostridium butyricum: A Promising Probiotic for Inflammatory Bowel Disease through Modulation of Gut Microbiota and Immunity.Probiotics Antimicrob Proteins2026https://conductscience.org/library/papers/42925396PubMed
42,905,293The Crosstalk Role of Intestinal Barrier Damage in the Gut-Organ Axis and its Potential Therapeutic Implications.Curr Microbiol2026https://conductscience.org/library/papers/42905293PubMed
42,894,724Effects of maternal supplementation with fatty acid-balanced oil on the performance of sows and intestinal barrier function of offspring.Anim Nutr2026https://conductscience.org/library/papers/42894724PubMed
42,842,553Feeding a low-protein diet exacerbates the susceptibility to Citrobacter rodentium and dextran sulfate sodium-induced intestinal injury in mice.PLoS One2026https://conductscience.org/library/papers/42842553PubMed
42,757,455ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review).Int J Mol Med2026https://conductscience.org/library/papers/42757455PubMed
42,755,181Targeting the gut-bone axis in osteoporosis: probiotic interventions and other microbiota-based therapeutic strategies.Gut Microbes2026https://conductscience.org/library/papers/42755181PubMed

1 to 10 of 671

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Genes16

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AHR196PubTator's text mininghttps://conductscience.org/library/genes/196NCBI Gene
CD28940PubTator's text mininghttps://conductscience.org/library/genes/940NCBI Gene
CD4920PubTator's text mininghttps://conductscience.org/library/genes/920NCBI Gene
FFAR32,865PubTator's text mininghttps://conductscience.org/library/genes/2865NCBI Gene
FOXP350,943PubTator's text mininghttps://conductscience.org/library/genes/50943NCBI Gene
HDAC99,734PubTator's text mininghttps://conductscience.org/library/genes/9734NCBI Gene
HIF1A3,091PubTator's text mininghttps://conductscience.org/library/genes/3091NCBI Gene
IFNG3,458PubTator's text mininghttps://conductscience.org/library/genes/3458NCBI Gene
IL103,586PubTator's text mininghttps://conductscience.org/library/genes/3586NCBI Gene
IL12B3,593PubTator's text mininghttps://conductscience.org/library/genes/3593NCBI Gene

1 to 10 of 16

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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