Paper · 33000412

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.

Koppula P and 2 others. Protein Cell, 2021. Cited by 2,201 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

Cite this record

ConductScience Library. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Papers, record 33000412. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33000412

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title: Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.; PubMed
Journal: Protein Cell; PubMed
Year: 2021; PubMed
Publication types: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review; PubMed
PubMed: https://pubmed.ncbi.nlm.nih.gov/33000412/; PubMed
DOI: https://doi.org/10.1007/s13238-020-00789-5; PubMed
PMC: https://pmc.ncbi.nlm.nih.gov/articles/PMC8310547/; PubMed
The journal: https://conductscience.org/library/journal-index/101532368; PubMed
Citations, by iCite: 2,201; iCite
Relative citation ratio, by iCite: 141; iCite
Revised in PubMed: 2022-01-26; PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

Order	Author	Forename
1	Koppula P	Pranavi
2	Zhuang L	Li
3	Gan B	Boyi

Source PubMed

Topics17

NLM's MeSH indexing of the paper, its major topics first.

MeSH term	Major
Amino Acid Transport System y+	Major topic
Antineoplastic Agents	Major topic
Cystine	Major topic
Ferroptosis	Major topic
Neoplasms	Major topic
DNA Methylation
Gene Expression Regulation, Neoplastic
Glucose
Glutamine
Glutathione
Histones
Humans
Molecular Targeted Therapy
Piperazines
Signal Transduction
Sorafenib
Sulfasalazine

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes it	Agency	Country	NIH project	Stated by	Source
R01 CA181196	NCI NIH HHS	United States	R01CA181196	PubMed and NIH	NIH RePORTER
R01 CA190370	NCI NIH HHS	United States	R01CA190370	PubMed and NIH	NIH RePORTER
R01 CA244144	NCI NIH HHS	United States	R01CA244144	PubMed and NIH	NIH RePORTER
			R01CA247992	NIH	NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References128

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

Order	PMID	Title	Journal	Year	In Papers	Source
1	15,189,131	Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine.	Annu Rev Nutr	2004	https://conductscience.org/library/papers/15189131	PubMed
2	31,723,000	Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma.	Cancer Res	2020	https://conductscience.org/library/papers/31723000	PubMed
3	28,967,864	Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.	Elife	2017	https://conductscience.org/library/papers/28967864	PubMed
4	32,015,438	LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.	Nat Cell Biol	2020	https://conductscience.org/library/papers/32015438	PubMed
5	31,899,616	Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers.	ACS Chem Biol	2020	https://conductscience.org/library/papers/31899616	PubMed
6	16,144,837	Redox imbalance in cystine/glutamate transporter-deficient mice.	J Biol Chem	2005	https://conductscience.org/library/papers/16144837	PubMed
7	28,427,863	ROS in Cancer: The Burning Question.	Trends Mol Med	2017	https://conductscience.org/library/papers/28427863	PubMed
8	16,103,098	Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance.	Cancer Res	2005	https://conductscience.org/library/papers/16103098	PubMed
9	32,294,465	The Chemistry and Biology of Ferroptosis.	Cell Chem Biol	2020	https://conductscience.org/library/papers/32294465	PubMed
10	9,915,839	4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer.	J Biol Chem	1999	https://conductscience.org/library/papers/9915839	PubMed

1 to 10 of 128

See all 128 references

Cited by1,516

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 2,201 citations.

PMID	Title	Journal	Year	In Papers	Source
42,985,219	Cross-Cohort Transcriptomic and Oral Microbiome Analyses Identify Ferroptosis-Associated Signatures in Periodontitis and Oral Squamous Cell Carcinoma.	Int J Genomics	2026	https://conductscience.org/library/papers/42985219	PubMed
42,980,886	IAP proteins and ferroptosis in breast cancer: an evidence framework for the ILP-2 hypothesis.	Mol Biol Rep	2026	https://conductscience.org/library/papers/42980886	PubMed
42,965,729	CircCCNB1 Inhibits Ferroptosis in Glioblastoma Cells via the USP4/IGF2BP1/SLC7A11 Axis.	Neurochem Res	2026	https://conductscience.org/library/papers/42965729	PubMed
42,964,170	A predefined sulphur-handling transcriptional programme is associated with colorectal cancer molecular subtypes.	Front Oncol	2026	https://conductscience.org/library/papers/42964170	PubMed
42,957,652	Cancer-associated fibroblasts: origins, functional heterogeneity and therapeutic potential.	Signal Transduct Target Ther	2026	https://conductscience.org/library/papers/42957652	PubMed
42,942,362	Peripheral Blood Mononuclear Cell Expression Profile of Proliferation-, Ferroptosis-, and Immune-Related Targets in Breast Cancer.	Medicina (Kaunas)	2026	https://conductscience.org/library/papers/42942362	PubMed
42,942,148	Derivatives of Dictyostelium Differentiation-Inducing Factor-3 Promote Autophagic Flux, Mitochondrial Dysfunction and Iron-Associated Oxidative Stress.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42942148	PubMed
42,942,016	Lipid Metabolism and Ferroptosis in Cancer: Regulatory Mechanisms, Alternative Splicing, and Therapeutic Implications.	Int J Mol Sci	2026	https://conductscience.org/library/papers/42942016	PubMed
42,941,223	Salidroside Regulates Energy Metabolism Reprogramming to Suppress Tumor Proliferation: Mechanisms and Therapeutic Implications.	Metabolites	2026	https://conductscience.org/library/papers/42941223	PubMed
42,940,203	Ferroptosis in Intervertebral Disc Degeneration: How the Extreme Microenvironment Rewires a Cell Death Network.	Biomedicines	2026	https://conductscience.org/library/papers/42940203	PubMed

1 to 10 of 1,516

See all 1,516 cited by

Genes14

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

Gene	NCBI Gene ID	Linked by	In Genes	Source
ACSL4	2,182	PubTator's text mining	https://conductscience.org/library/genes/2182	NCBI Gene
ALOX12	239	PubTator's text mining	https://conductscience.org/library/genes/239	NCBI Gene
ATF4	468	PubTator's text mining	https://conductscience.org/library/genes/468	NCBI Gene
BAP1	8,314	PubTator's text mining	https://conductscience.org/library/genes/8314	NCBI Gene
ETS1	2,113	PubTator's text mining	https://conductscience.org/library/genes/2113	NCBI Gene
GLS	2,744	PubTator's text mining	https://conductscience.org/library/genes/2744	NCBI Gene
GPX4	2,879	PubTator's text mining	https://conductscience.org/library/genes/2879	NCBI Gene
KEAP1	9,817	PubTator's text mining	https://conductscience.org/library/genes/9817	NCBI Gene
KRAS	3,845	PubTator's text mining	https://conductscience.org/library/genes/3845	NCBI Gene
NFE2L2	4,780	PubTator's text mining	https://conductscience.org/library/genes/4780	NCBI Gene

1 to 10 of 14

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed: 2026-11-06; PubMed
iCite: 2026-11-05; iCite
PMC's ID file: 2026-11-05; PMC's ID file
NIH RePORTER's grant and paper links: 2026-11-01; NIH RePORTER's grant and paper links
Trials: 2026-11-12
Gene search: 2026-11-11
Pipelines: 2026-09-18

Sources 11

ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
HGNCCC0
iCiteCC BY 4.0
NCBI GenePublic domain (US government)
NIH RePORTER's grant and paper linksPublic domain
Open TargetsCC0 1.0
PMC's ID filePublic domain (US government)
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0

Each source's terms

ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
HGNCCC0: https://www.genenames.org/about/license/
iCiteCC BY 4.0
NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
PubMedNLM's terms
PubTator 3Public domain
UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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