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Paper · 33744934

Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication.

Bainbridge LJ and 2 others. Nucleic Acids Res, 2021. Cited by 46 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication. Papers, record 33744934. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/33744934

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Repriming DNA synthesis: an intrinsic restart pathway that maintains efficient genome replication.
PubMed
Journal
Nucleic Acids Res
PubMed
Year
2021
PubMed
Publication types
Historical Article, Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
Citations, by iCite
46
iCite
Relative citation ratio, by iCite
2.39
iCite
Revised in PubMed
2025-05-30
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Bainbridge LJLewis Jhttps://orcid.org/0000-0002-4037-9516
2Teague RRebeccahttps://orcid.org/0000-0002-7045-3561
3Doherty AJAidan Jhttps://orcid.org/0000-0002-6370-1109

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
DNAMajor topic
DNA ReplicationMajor topic
Animals
DNA Damage
DNA Primase
DNA-Directed DNA Polymerase
Genome
History, 20th Century
Models, Genetic
Stress, Physiological

Source PubMed

Grants3

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
Wellcome TrustUnited KingdomPubMed
BB/H019723/1Biotechnology and Biological Sciences Research CouncilUnited KingdomPubMed
BB/M008800/1Biotechnology and Biological Sciences Research CouncilUnited KingdomPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References174

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
132,826,907Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C.Nat Commun2020https://conductscience.org/library/papers/32826907PubMed
226,866,665MCM: one ring to rule them all.Curr Opin Struct Biol2016https://conductscience.org/library/papers/26866665PubMed
316,956,796Gaps and forks in DNA replication: Rediscovering old models.DNA Repair (Amst)2006https://conductscience.org/library/papers/16956796PubMed
417,707,226Characterization of a triple DNA polymerase replisome.Mol Cell2007https://conductscience.org/library/papers/17707226PubMed
59,974,380Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta.Science1999https://conductscience.org/library/papers/9974380PubMed
632,883,112An updated perspective on the polymerase division of labor during eukaryotic DNA replication.Crit Rev Biochem Mol Biol2020https://conductscience.org/library/papers/32883112PubMed
723,892,402A new strategy for gene targeting and functional proteomics using the DT40 cell line.Nucleic Acids Res2013https://conductscience.org/library/papers/23892402PubMed
821,981,920CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.Mol Cell2011https://conductscience.org/library/papers/21981920PubMed
927,262,731DNA Polymerases Divide the Labor of Genome Replication.Trends Cell Biol2016https://conductscience.org/library/papers/27262731PubMed
10817,735Evidence that both growing DNA chains at a replication fork are synthesized discontinuously.Biochemistry1976https://conductscience.org/library/papers/817735PubMed

1 to 10 of 174

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Cited by39

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 46 citations.

PMIDTitleJournalYearIn PapersSource
42,480,506Increased replication-associated single-stranded DNA promotes formaldehyde-induced mutagenesis in Saccharomyces cerevisiae.Genetics2026https://conductscience.org/library/papers/42480506PubMed
42,302,790FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity.Mol Cell2026https://conductscience.org/library/papers/42302790PubMed
42,094,416Increased replication-associated single-stranded DNA promotes formaldehyde-induced mutagenesis.bioRxiv2026https://conductscience.org/library/papers/42094416PubMed
41,974,659Recurrent MBTPS2 variant c.970+5G>A in IFAP syndrome: a mutational hotspot.Hum Genome Var2026https://conductscience.org/library/papers/41974659PubMed
41,750,275Generation of Human Haematopoietic Model Cell Lines Revealed Distinct Replication Stress Tolerance Between Two Oncogenic KRAS Mutations, G12V and A146T.Biomolecules2026https://conductscience.org/library/papers/41750275PubMed
41,741,471The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells.Nat Commun2026https://conductscience.org/library/papers/41741471PubMed
41,675,985A Quantitative DNA Fiber Assay to Monitor Replication Fork Progression, Protection, and Restart.Bio Protoc2026https://conductscience.org/library/papers/41675985PubMed
41,514,018RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.Nat Cell Biol2026https://conductscience.org/library/papers/41514018PubMed
41,370,868How DNA secondary structures drive replication fork instability.DNA Repair (Amst)2025https://conductscience.org/library/papers/41370868PubMed
41,303,849Cellular and Molecular Mechanisms of Oxidative DNA Damage and Repair.Medicina (Kaunas)2025https://conductscience.org/library/papers/41303849PubMed

1 to 10 of 39

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Genes37

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AICDA57,379PubTator's text mininghttps://conductscience.org/library/genes/57379NCBI Gene
ATR545PubTator's text mininghttps://conductscience.org/library/genes/545NCBI Gene
BLM641PubTator's text mininghttps://conductscience.org/library/genes/641NCBI Gene
BRCA1672PubTator's text mininghttps://conductscience.org/library/genes/672NCBI Gene
BRCA2675PubTator's text mininghttps://conductscience.org/library/genes/675NCBI Gene
CARM110,498PubTator's text mininghttps://conductscience.org/library/genes/10498NCBI Gene
CHEK11,111PubTator's text mininghttps://conductscience.org/library/genes/1111NCBI Gene
DNAH81,769PubTator's text mininghttps://conductscience.org/library/genes/1769NCBI Gene
EXO19,156PubTator's text mininghttps://conductscience.org/library/genes/9156NCBI Gene
FEN12,237PubTator's text mininghttps://conductscience.org/library/genes/2237NCBI Gene

1 to 10 of 37

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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