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Paper · 34717954

The insulin centennial-100 years of milestones in biochemistry.

Attie AD and 2 others. J Biol Chem, 2021. Cited by 3 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. The insulin centennial-100 years of milestones in biochemistry. Papers, record 34717954. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34717954

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
The insulin centennial-100 years of milestones in biochemistry.
PubMed
Journal
J Biol Chem
PubMed
Year
2021
PubMed
Publication types
Editorial, Historical Article, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
3
iCite
Relative citation ratio, by iCite
0.2
iCite
Revised in PubMed
2024-04-04
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Attie ADAlan D
2Tang QQQi-Qun
3Bornfeldt KEKarin E

Source PubMed

Topics5

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
BiochemistryMajor topic
InsulinMajor topic
History, 20th Century
History, 21st Century
Humans

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P01 HL151328NHLBI NIH HHSUnited StatesP01HL151328PubMed and NIHNIH RePORTER
R01 DK101573NIDDK NIH HHSUnited StatesR01DK101573PubMed and NIHNIH RePORTER
R35 HL150754NHLBI NIH HHSUnited StatesR35HL150754PubMed and NIHNIH RePORTER
RC2 DK125961NIDDK NIH HHSUnited StatesRC2DK125961PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References120

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
111,018,078Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1.J Clin Invest2000https://conductscience.org/library/papers/11018078PubMed
215,292,255Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes.J Biol Chem2004https://conductscience.org/library/papers/15292255PubMed
314,527,948Lipase-selective functional domains of perilipin A differentially regulate constitutive and protein kinase A-stimulated lipolysis.J Biol Chem2003https://conductscience.org/library/papers/14527948PubMed
419,850,935Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl).J Biol Chem2009https://conductscience.org/library/papers/19850935PubMed
533,492,422The discovery of insulin in Toronto: beginning a 100 year journey of research and clinical achievement.Diabetologia2021https://conductscience.org/library/papers/33492422PubMed
632,907,986Membrane-bound sn-1,2-diacylglycerols explain the dissociation of hepatic insulin resistance from hepatic steatosis in MTTP knockout mice.J Lipid Res2020https://conductscience.org/library/papers/32907986PubMed
715,115,830Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes.N Engl J Med2004https://conductscience.org/library/papers/15115830PubMed
89,844,629A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance.Mol Cell1998https://conductscience.org/library/papers/9844629PubMed
9170,678Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance.Science1975https://conductscience.org/library/papers/170678PubMed
101,536,560Effects of fluorescein isothiocyanate on insulin actions in rat adipocytes.Arch Biochem Biophys1992https://conductscience.org/library/papers/1536560PubMed

1 to 10 of 120

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Cited by1

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 3 citations.

PMIDTitleJournalYearIn Papers
36,994,866Insulin resistance and cardiovascular disease.J Int Med Res2023https://conductscience.org/library/papers/36994866

Source PubMed

Genes37

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ABCC86,833PubTator's text mininghttps://conductscience.org/library/genes/6833NCBI Gene
ABCC910,060PubTator's text mininghttps://conductscience.org/library/genes/10060NCBI Gene
ABHD551,099PubTator's text mininghttps://conductscience.org/library/genes/51099NCBI Gene
ADRA2B151PubTator's text mininghttps://conductscience.org/library/genes/151NCBI Gene
ALB213PubTator's text mininghttps://conductscience.org/library/genes/213NCBI Gene
AWAT1158,833PubTator's text mininghttps://conductscience.org/library/genes/158833NCBI Gene
EPHB22,048PubTator's text mininghttps://conductscience.org/library/genes/2048NCBI Gene
FFAR12,864PubTator's text mininghttps://conductscience.org/library/genes/2864NCBI Gene
FOXO12,308PubTator's text mininghttps://conductscience.org/library/genes/2308NCBI Gene
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene

1 to 10 of 37

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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