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Paper · 34839558

SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma.

Meng F and 5 others. Cancer Sci, 2022. Cited by 10 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma. Papers, record 34839558. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/34839558

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma.
PubMed
Journal
Cancer Sci
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
10
iCite
Relative citation ratio, by iCite
0.81
iCite
Revised in PubMed
2025-01-03
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Meng FFengxihttps://orcid.org/0000-0002-1742-3283
2Yuan YYiqun
3Ren HHui
4Yue HHan
5Xu BBinbin
6Qian JJiang

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
MelanomaMajor topic
Retinoblastoma Binding ProteinsMajor topic
SumoylationMajor topic
Ubiquitin-Protein LigasesMajor topic
Uveal NeoplasmsMajor topic
Animals
Apoptosis
Cell Line, Tumor
Cell Proliferation
Humans
Mice
Phosphorylation
SUMO-1 Protein
Uveal Melanoma

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
81970835National Natural Science Foundation of ChinaPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References49

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
129,049,518Long-term Outcomes After Proton Beam Irradiation in Patients With Large Choroidal Melanomas.JAMA Ophthalmol2017https://conductscience.org/library/papers/29049518PubMed
224,938,562Effect of selumetinib vs chemotherapy on progression-free survival in uveal melanoma: a randomized clinical trial.JAMA2014https://conductscience.org/library/papers/24938562PubMed
310,969,768Inactivation of retinoblastoma protein in uveal melanoma by phosphorylation of sites in the COOH-terminal region.Cancer Res2000https://conductscience.org/library/papers/10969768PubMed
415,087,395Overexpression of a dominant-negative mutant Ubc9 is associated with increased sensitivity to anticancer drugs.Cancer Res2004https://conductscience.org/library/papers/15087395PubMed
518,239,126Cancer proliferation gene discovery through functional genomics.Science2008https://conductscience.org/library/papers/18239126PubMed
619,078,957Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.Nature2009https://conductscience.org/library/papers/19078957PubMed
79,694,791The regulation of E2F by pRB-family proteins.Genes Dev1998https://conductscience.org/library/papers/9694791PubMed
824,953,629SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression.Nat Commun2014https://conductscience.org/library/papers/24953629PubMed
99,247,253Expression of MAGE genes in ocular melanoma during progression from primary to metastatic disease.Clin Exp Metastasis1997https://conductscience.org/library/papers/9247253PubMed
108,505,203Studies of human uveal melanocytes in vitro: isolation, purification and cultivation of human uveal melanocytes.Invest Ophthalmol Vis Sci1993https://conductscience.org/library/papers/8505203PubMed

1 to 10 of 49

See all 49 references

Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 10 citations.

PMIDTitleJournalYearIn PapersSource
42,212,122Post-translational modifications in retinoblastoma: mechanisms, immune regulation, and therapeutic opportunities.Front Immunol2026https://conductscience.org/library/papers/42212122PubMed
41,930,165Epigenetics of Malignant Melanoma: Mechanisms, Diagnostic Approaches and Therapeutic Applications.Oncol Res2026https://conductscience.org/library/papers/41930165PubMed
41,674,654Blockage of SUMO E1 enzyme inhibits ocular lens fibrosis by mediating SMAD4 SUMOylation.Genes Dis2026https://conductscience.org/library/papers/41674654PubMed
40,177,537Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review.Explor Target Antitumor Ther2025https://conductscience.org/library/papers/40177537PubMed
36,558,920Pharmacological Activities of Ginkgolic Acids in Relation to Autophagy.Pharmaceuticals (Basel)2022https://conductscience.org/library/papers/36558920PubMed
36,361,724Contribution of Microhomology to Genome Instability: Connection between DNA Repair and Replication Stress.Int J Mol Sci2022https://conductscience.org/library/papers/36361724PubMed
34,839,558SUMOylation regulates Rb hyperphosphorylation and inactivation in uveal melanoma.Cancer Sci2022https://conductscience.org/library/papers/34839558PubMed

Genes22

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
BAP18,314PubTator's text mininghttps://conductscience.org/library/genes/8314NCBI Gene
CCNL281,669PubTator's text mininghttps://conductscience.org/library/genes/81669NCBI Gene
CDK21,017PubTator's text mininghttps://conductscience.org/library/genes/1017NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
GNA112,767PubTator's text mininghttps://conductscience.org/library/genes/2767NCBI Gene
GNAQ2,776PubTator's text mininghttps://conductscience.org/library/genes/2776NCBI Gene
MAP2K75,609PubTator's text mininghttps://conductscience.org/library/genes/5609NCBI Gene
PIK3R15,295PubTator's text mininghttps://conductscience.org/library/genes/5295NCBI Gene

1 to 10 of 22

See all 22 genes

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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