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Paper · 35355018

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.

Kadur Lakshminarasimha Murthy P and 15 others. Nature, 2022. Cited by 279 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. Papers, record 35355018. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35355018

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.
PubMed
Journal
Nature
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
279
iCite
Relative citation ratio, by iCite
18.6
iCite
Revised in PubMed
2024-03-29
PubMed

Authors16

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Kadur Lakshminarasimha Murthy PPreetish
2Sontake VVishwarajhttps://orcid.org/0000-0002-8532-7680
3Tata AAleksandra
4Kobayashi YYoshihiko
5Macadlo LLauren
6Okuda KKenichihttps://orcid.org/0000-0001-9341-2730
7Conchola ASAnsley Shttps://orcid.org/0000-0002-2385-6712
8Nakano SSatoko
9Gregory SSimon
10Miller LALisa A

1 to 10 of 16Source PubMed

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Topics16

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Cell LineageMajor topic
LungMajor topic
Stem CellsMajor topic
Alveolar Epithelial Cells
Animals
Cell Differentiation
Connectome
Fibroblasts
Gene Expression Profiling
Humans
Lung Diseases
Mice
Organoids
Primates
Regeneration
Single-Cell Analysis

Source PubMed

Grants15

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 HL119215NHLBI NIH HHSUnited StatesR01HL119215PubMed and NIHNIH RePORTER
R01 HL153375NHLBI NIH HHSUnited StatesR01HL153375PubMed and NIHNIH RePORTER
R00 HL127181NHLBI NIH HHSUnited StatesR00HL127181PubMed and NIHNIH RePORTER
R24 HD000836NICHD NIH HHSUnited StatesR24HD000836PubMed and NIHNIH RePORTER
R01 HL165404NHLBI NIH HHSUnited StatesR01HL165404PubMedNIH RePORTER
P51 OD011107NIH HHSUnited StatesP51OD011107PubMed and NIHNIH RePORTER
R01 HL127002NHLBI NIH HHSUnited StatesR01HL127002PubMed and NIHNIH RePORTER
P30 CA014236NCI NIH HHSUnited StatesP30CA014236PubMed and NIHNIH RePORTER
P30 DK054759NIDDK NIH HHSUnited StatesP30DK054759PubMedNIH RePORTER
U01 HL134766NHLBI NIH HHSUnited StatesU01HL134766PubMed and NIHNIH RePORTER

1 to 10 of 15

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References56

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
132,061,334Small airways pathology in idiopathic pulmonary fibrosis: a retrospective cohort study.Lancet Respir Med2020https://conductscience.org/library/papers/32061334PubMed
25,610,792The resistance of small airways in normal and diseased human lungs.Aspen Emphysema Conf1967https://conductscience.org/library/papers/5610792PubMed
327,611,890Micro-Computed Tomography Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema.Am J Respir Crit Care Med2017https://conductscience.org/library/papers/27611890PubMed
414,005,590Architecture of the human lung. Use of quantitative methods establishes fundamental relations between size and number of lung structures.Science1962https://conductscience.org/library/papers/14005590PubMed
532,661,339Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.Nat Cell Biol2020https://conductscience.org/library/papers/32661339PubMed
632,678,092Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis.Nat Commun2020https://conductscience.org/library/papers/32678092PubMed
732,750,316Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.Cell Stem Cell2020https://conductscience.org/library/papers/32750316PubMed
829,206,104The Human Cell Atlas.Elife2017https://conductscience.org/library/papers/29206104PubMed
926,000,488Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets.Cell2015https://conductscience.org/library/papers/26000488PubMed
1026,000,487Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells.Cell2015https://conductscience.org/library/papers/26000487PubMed

1 to 10 of 56

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Cited by224

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 279 citations.

PMIDTitleJournalYearIn PapersSource
42,926,426A tonic PDGFA-dependent niche organizer maintains alveolar homeostasis.bioRxiv2026https://conductscience.org/library/papers/42926426PubMed
42,864,331LGR5-positive fibroblasts orchestrate skin mechanoadaptation through JAK1 modulation.Nat Commun2026https://conductscience.org/library/papers/42864331PubMed
42,862,716Single-cell transcriptomic atlas uncovers immune/structural lineage remodeling and fibrosis in Klebsiella pneumoniae-infected porcine lungs.Virulence2026https://conductscience.org/library/papers/42862716PubMed
42,844,469Alveolar stem cells transdifferentiate to drive bronchiolar regeneration.Nature2026https://conductscience.org/library/papers/42844469PubMed
42,827,249Airway cell-cell communication in smoking through integration of spatial and single-cell transcriptomics.Respir Res2026https://conductscience.org/library/papers/42827249PubMed
42,812,152Co-optation of the regenerative role of type 2 alveolar cells in distal lung repair in mice by terminal airway epithelial cells in humans.bioRxiv2026https://conductscience.org/library/papers/42812152PubMed
42,778,202Defective alveolar regeneration in emphysema: identifying dysfunctional cellular crosstalk and novel therapeutic opportunities for tissue repair.Eur Respir Rev2026https://conductscience.org/library/papers/42778202PubMed
42,719,019Temporal regulation of wnt signaling in alveolar development and regeneration: mechanistic insights and therapeutic advances in chronic lung diseases.Front Cell Dev Biol2026https://conductscience.org/library/papers/42719019PubMed
42,683,067ERS Congress 2025: highlights from the Basic and Translational Sciences Assembly.ERJ Open Res2026https://conductscience.org/library/papers/42683067PubMed
42,613,076Ageing-associated regenerative failure in the lung: stem cell senescence and transitional cell persistence in idiopathic pulmonary fibrosis.Eur Respir Rev2026https://conductscience.org/library/papers/42613076PubMed

1 to 10 of 224

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Genes80

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ACTA259PubTator's text mininghttps://conductscience.org/library/genes/59NCBI Gene
ACTB60PubTator's text mininghttps://conductscience.org/library/genes/60NCBI Gene
AGER177PubTator's text mininghttps://conductscience.org/library/genes/177NCBI Gene
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
AQP5362PubTator's text mininghttps://conductscience.org/library/genes/362NCBI Gene
BDNF627PubTator's text mininghttps://conductscience.org/library/genes/627NCBI Gene
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
BMPR1B658PubTator's text mininghttps://conductscience.org/library/genes/658NCBI Gene
BMPR2659PubTator's text mininghttps://conductscience.org/library/genes/659NCBI Gene
BST2684PubTator's text mininghttps://conductscience.org/library/genes/684NCBI Gene

1 to 10 of 80

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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