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Paper · 35474341

Role of the gut-brain axis in energy and glucose metabolism.

Wachsmuth HR and 2 others. Exp Mol Med, 2022. Cited by 210 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Role of the gut-brain axis in energy and glucose metabolism. Papers, record 35474341. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35474341

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of the gut-brain axis in energy and glucose metabolism.
PubMed
Journal
Exp Mol Med
PubMed
Year
2022
PubMed
Publication types
Journal Article, Review, Research Support, N.I.H., Extramural
PubMed
Citations, by iCite
210
iCite
Relative citation ratio, by iCite
18.4
iCite
Revised in PubMed
2025-07-28
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Wachsmuth HRHallie R
2Weninger SNSavanna N
3Duca FAFrank A

Source PubMed

Topics8

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Brain-Gut AxisMajor topic
Gastrointestinal MicrobiomeMajor topic
Brain
Energy Metabolism
Glucose
Homeostasis
Humans
Obesity

Source PubMed

Grants1

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
R01 DK121804NIDDK NIH HHSUnited StatesR01DK121804PubMed and NIH

Source NIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References293

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
131,518,657Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition.Diabetes Res Clin Pract2019https://conductscience.org/library/papers/31518657PubMed
228,212,973The Burden of Obesity on Diabetes in the United States: Medical Expenditure Panel Survey, 2008 to 2012.Value Health2017https://conductscience.org/library/papers/28212973PubMed
328,530,702Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.Nat Med2017https://conductscience.org/library/papers/28530702PubMed
425,849,133Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.Nat Med2015https://conductscience.org/library/papers/25849133PubMed
530,397,356Gut microbiota and intestinal FXR mediate the clinical benefits of metformin.Nat Med2018https://conductscience.org/library/papers/30397356PubMed
629,065,411Gut Microbiota and Host Metabolism: What Relationship.Neuroendocrinology2018https://conductscience.org/library/papers/29065411PubMed
732,170,068Temporospatial shifts in the human gut microbiome and metabolome after gastric bypass surgery.NPJ Biofilms Microbiomes2020https://conductscience.org/library/papers/32170068PubMed
911,557,510Vagal afferent responses to fatty acids of different chain length in the rat.Am J Physiol Gastrointest Liver Physiol2001https://conductscience.org/library/papers/11557510PubMed
1027,591,963Novel developments in vagal afferent nutrient sensing and its role in energy homeostasis.Curr Opin Pharmacol2016https://conductscience.org/library/papers/27591963PubMed
1110,766,253Central nervous system control of food intake.Nature2000https://conductscience.org/library/papers/10766253PubMed

1 to 10 of 293

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Cited by153

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 210 citations.

PMIDTitleJournalYearIn PapersSource
42,982,796Gut and oral microbiota composition is associated with psychopathic personality: a cross-sectional study.Transl Psychiatry2026https://conductscience.org/library/papers/42982796PubMed
42,886,170Schizophrenia-associated gut microbiota are linked to reduced colonic PRODH expression and behavioral changes in mice.Gut Microbes2026https://conductscience.org/library/papers/42886170PubMed
42,723,213Cholecystokinin Induces Ca2+ Transients in Brainstem Neurons, Astrocytes and Central Vagal Terminals in Jugular/Nodose Ganglia-Brainstem Slice Cultures.Eur J Neurosci2026https://conductscience.org/library/papers/42723213PubMed
42,683,250Seasonal Variation of Gut Bacterial Community in Wild Apodemus agrarius Is Associated With Intrinsic and Extrinsic Environments.Ecol Evol2026https://conductscience.org/library/papers/42683250PubMed
42,681,658The gut neuroepithelial unit as a neurodegeneration-relevant interface in the gut-brain axis.Transl Neurodegener2026https://conductscience.org/library/papers/42681658PubMed
42,662,708The liver-gut-brain axis in metabolic dysfunction-associated steatotic liver disease: bidirectional communication, clinical implications, and future perspectives.Front Endocrinol (Lausanne)2026https://conductscience.org/library/papers/42662708PubMed
42,650,836Endogenous Lipid Signals in Energy Homeostasis and Fibrosis.Biomolecules2026https://conductscience.org/library/papers/42650836PubMed
42,535,110The vagus nerve as a neurovisceral interface: a comprehensive review.Front Neurosci2026https://conductscience.org/library/papers/42535110PubMed
42,533,574Metabolomic insights into the response strategies of bats to high-glucose stimulation.Zool Res2026https://conductscience.org/library/papers/42533574PubMed
42,511,500KBN2201 Attenuates High-Fat Diet-Induced Adipose Tissue Expansion and Body Weight Gain in Male Mice.Int J Mol Sci2026https://conductscience.org/library/papers/42511500PubMed

1 to 10 of 153

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Genes15

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
CASR846PubTator's text mininghttps://conductscience.org/library/genes/846NCBI Gene
CCK885PubTator's text mininghttps://conductscience.org/library/genes/885NCBI Gene
CCKAR886PubTator's text mininghttps://conductscience.org/library/genes/886NCBI Gene
FFAR12,864PubTator's text mininghttps://conductscience.org/library/genes/2864NCBI Gene
FFAR22,867PubTator's text mininghttps://conductscience.org/library/genes/2867NCBI Gene
FFAR4338,557PubTator's text mininghttps://conductscience.org/library/genes/338557NCBI Gene
FOS2,353PubTator's text mininghttps://conductscience.org/library/genes/2353NCBI Gene
GCG2,641PubTator's text mininghttps://conductscience.org/library/genes/2641NCBI Gene
GHSR2,693PubTator's text mininghttps://conductscience.org/library/genes/2693NCBI Gene
GIP2,695PubTator's text mininghttps://conductscience.org/library/genes/2695NCBI Gene

1 to 10 of 15

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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