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Paper · 35478224

Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia.

Cruz NM and 5 others. Nat Biomed Eng, 2022. Cited by 33 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia. Papers, record 35478224. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35478224

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia.
PubMed
Journal
Nat Biomed Eng
PubMed
Year
2022
PubMed
Publication types
Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
PubMed
Citations, by iCite
33
iCite
Relative citation ratio, by iCite
2.17
iCite
Revised in PubMed
2024-09-23
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Cruz NMNelly Mhttps://orcid.org/0000-0002-9040-6957
2Reddy RRaghava
3McFaline-Figueroa JLJosé Lhttps://orcid.org/0000-0003-4387-1511
4Tran CChristine
5Fu HHongxia
6Freedman BSBenjamin Shttps://orcid.org/0000-0003-2228-7383

Source PubMed

Topics7

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
CiliopathiesMajor topic
Pluripotent Stem CellsMajor topic
Cilia
Hedgehog Proteins
Humans
Kinesins
Phenotype

Source PubMed

Grants12

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
K25 HL135432NHLBI NIH HHSUnited StatesK25HL135432PubMed and NIHNIH RePORTER
UH3 TR000504NCATS NIH HHSUnited StatesUH2TR000504PubMed and NIHNIH RePORTER
UH3 TR002158NCATS NIH HHSUnited StatesUG3TR002158PubMed and NIHNIH RePORTER
UG3 TR002158NCATS NIH HHSUnited StatesUG3TR002158PubMed and NIHNIH RePORTER
UH3 TR003288NCATS NIH HHSUnited StatesUG3TR003288PubMed and NIHNIH RePORTER
U01 EB028892NIBIB NIH HHSUnited StatesU01EB028892PubMed and NIHNIH RePORTER
R01 DK117914NIDDK NIH HHSUnited StatesR01DK117914PubMed and NIHNIH RePORTER
UC2 DK126006NIDDK NIH HHSUnited StatesUC2DK126006PubMed and NIHNIH RePORTER
UG3 TR003288NCATS NIH HHSUnited StatesUG3TR003288PubMed and NIHNIH RePORTER
UH2 TR000504NCATS NIH HHSUnited StatesUH2TR000504PubMed and NIHNIH RePORTER

1 to 10 of 12

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Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Erratum in35,610,484Author Correction: Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia.https://conductscience.org/library/papers/35610484

Source PubMed

References62

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
25,661,997Reconstructions of centriole formation and ciliogenesis in mammalian lungs.J Cell Sci1968https://conductscience.org/library/papers/5661997PubMed
312,859,898Two populations of node monocilia initiate left-right asymmetry in the mouse.Cell2003https://conductscience.org/library/papers/12859898PubMed
48,516,294A motility in the eukaryotic flagellum unrelated to flagellar beating.Proc Natl Acad Sci U S A1993https://conductscience.org/library/papers/8516294PubMed
510,227,290Movement of motor and cargo along cilia.Nature1999https://conductscience.org/library/papers/10227290PubMed
627,765,513Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.Trends Cell Biol2017https://conductscience.org/library/papers/27765513PubMed
712,872,123Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination.Nat Genet2003https://conductscience.org/library/papers/12872123PubMed
817,574,030A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.Cell2007https://conductscience.org/library/papers/17574030PubMed
914,520,415Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome.Nature2003https://conductscience.org/library/papers/14520415PubMed
1021,394,081Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry.Nat Cell Biol2011https://conductscience.org/library/papers/21394081PubMed
115,365,371Cilia in cardiac differentiation.J Ultrastruct Res1969https://conductscience.org/library/papers/5365371PubMed

1 to 10 of 62

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Cited by24

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 33 citations.

PMIDTitleJournalYearIn PapersSource
41,667,710Developmentally inspired synthetic kidney engineering.Nat Biotechnol2026https://conductscience.org/library/papers/41667710PubMed
41,530,266Monitoring biological effects of somatic cell genome editing.Nat Rev Genet2026https://conductscience.org/library/papers/41530266PubMed
41,161,866In vitro approaches to study centriole and cilium function in early mouse embryogenesis.Life Sci Alliance2026https://conductscience.org/library/papers/41161866PubMed
41,141,533Elucidating Mechanisms of Hypomorphic WDR19-Related Kidney Failure.Kidney Int Rep2025https://conductscience.org/library/papers/41141533PubMed
40,927,382CRISPR and gene editing for kidney diseases: where are we?Clin Kidney J2025https://conductscience.org/library/papers/40927382PubMed
40,875,857Transcription factors SP5 and SP8 drive primary cilia formation in mammalian embryos.Science2025https://conductscience.org/library/papers/40875857PubMed
40,841,925Developmental Hypoxia Enhances Kidney Organoid Complexity and Maturity.Adv Sci (Weinh)2025https://conductscience.org/library/papers/40841925PubMed
40,602,764Kidney organoids demonstrate that PTH1R drives a cystogenic cAMP-pPKA-pCREB axis in developmental polycystic kidney disease.Am J Physiol Renal Physiol2025https://conductscience.org/library/papers/40602764PubMed
40,499,561Kidney organoid models of polycystic kidney disease: challenges and future directions.Am J Physiol Renal Physiol2025https://conductscience.org/library/papers/40499561PubMed
40,247,123Imaging 3D cell cultures with optical microscopy.Nat Methods2025https://conductscience.org/library/papers/40247123PubMed

1 to 10 of 24

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Genes30

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
ARL13B200,894PubTator's text mininghttps://conductscience.org/library/genes/200894NCBI Gene
BMP4652PubTator's text mininghttps://conductscience.org/library/genes/652NCBI Gene
CD9928PubTator's text mininghttps://conductscience.org/library/genes/928NCBI Gene
CTNNB11,499PubTator's text mininghttps://conductscience.org/library/genes/1499NCBI Gene
EPCAM4,072PubTator's text mininghttps://conductscience.org/library/genes/4072NCBI Gene
FLOT110,211PubTator's text mininghttps://conductscience.org/library/genes/10211NCBI Gene
GLI12,735PubTator's text mininghttps://conductscience.org/library/genes/2735NCBI Gene
GLI22,736PubTator's text mininghttps://conductscience.org/library/genes/2736NCBI Gene
GLI32,737PubTator's text mininghttps://conductscience.org/library/genes/2737NCBI Gene

1 to 10 of 30

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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