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Paper · 35856444

BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer.

Chen Z and 4 others. Cell Cycle, 2022. Cited by 19 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer. Papers, record 35856444. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/35856444

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
BMP2 inhibits cell proliferation by downregulating EZH2 in gastric cancer.
PubMed
Journal
Cell Cycle
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
19
iCite
Relative citation ratio, by iCite
1.46
iCite
Revised in PubMed
2023-07-21
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Chen ZZilu
2Yuan LLiyue
3Li XXiaopeng
4Yu JJunhui
5Xu ZZhengshuihttps://orcid.org/0000-0003-0934-3205

Source PubMed

Topics13

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Enhancer of Zeste Homolog 2 ProteinMajor topic
Stomach NeoplasmsMajor topic
Bone Morphogenetic Protein 2
Cell Line, Tumor
Cell Proliferation
Endothelial Cells
Epigenesis, Genetic
Histones
Humans
Lysine
RNA, Small Interfering
Transforming Growth Factor beta
Transforming Growth Factors

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References43

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
131,489,377Combinatorial morphogenetic and mechanical cues to mimic bone development for defect repair.Sci Adv2019https://conductscience.org/library/papers/31489377PubMed
216,314,833Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas.Oncogene2006https://conductscience.org/library/papers/16314833PubMed
319,688,119The Bone Morphogenesis Protein-2 (BMP-2) is associated with progression to metastatic disease in gastric cancer.Cancer Res Treat2008https://conductscience.org/library/papers/19688119PubMed
4221,908Solubilized and insolubilized bone morphogenetic protein.Proc Natl Acad Sci U S A1979https://conductscience.org/library/papers/221908PubMed
533,275,394Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?Clin Orthop Relat Res2020https://conductscience.org/library/papers/33275394PubMed
610,910,126Application of efficient and specific gene transfer systems and organ culture techniques for the elucidation of mechanisms of epithelial-mesenchymal interaction in the developing gut.Dev Growth Differ2000https://conductscience.org/library/papers/10910126PubMed
712,860,278Aberrant signaling of TGF-beta1 by the mutant Smad4 in gastric cancer cells.Cancer Lett2003https://conductscience.org/library/papers/12860278PubMed
830,944,675Epidemiology of gastric cancer: global trends, risk factors and prevention.Prz Gastroenterol2019https://conductscience.org/library/papers/30944675PubMed
919,835,871BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway.Exp Cell Res2010https://conductscience.org/library/papers/19835871PubMed
1026,256,958Evolution of Gastric Cancer Treatment: From the Golden Age of Surgery to an Era of Precision Medicine.Yonsei Med J2015https://conductscience.org/library/papers/26256958PubMed

1 to 10 of 43

See all 43 references

Cited by14

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 19 citations.

PMIDTitleJournalYearIn PapersSource
42,619,032Unveiling the New Trick for Epigenetic Drug: Radiation Enhancement of Prostate Cancer by the EZH2 Inhibitor Tazemetostat.J Cell Mol Med2026https://conductscience.org/library/papers/42619032PubMed
42,366,126
Recombinant bone morphogenetic protein-2 attenuates colorectal cancer progression by orchestrating Hippo pathway activation, Yes-associated protein inhibition, and epithelial-mesenchymal transition suppression.
Korean J Physiol Pharmacol2026https://conductscience.org/library/papers/42366126PubMed
41,201,023Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations.Mol Med Rep2026https://conductscience.org/library/papers/41201023PubMed
40,185,978BMP2 expression in oral squamous cell carcinoma and its effects on SCC9 cell biological behavior.Sci Rep2025https://conductscience.org/library/papers/40185978PubMed
39,939,808Unveiling a novel model of cell senescence-related genes for prognostic assessment and immunotherapeutic insights in gastric cancer.Sci Rep2025https://conductscience.org/library/papers/39939808PubMed
39,697,756Prognostic significance of B cell senescence-associated genes as risk markers in prostate adenocarcinoma.Transl Cancer Res2024https://conductscience.org/library/papers/39697756PubMed
39,238,632Putative Dual Roles of Bone Morphogenetic Protein 8B (BMP8B) in Disease Progression of Gastric Cancer.Cancer Diagn Progn2024https://conductscience.org/library/papers/39238632PubMed
38,681,199Research progress and applications of epigenetic biomarkers in cancer.Front Pharmacol2024https://conductscience.org/library/papers/38681199PubMed
38,510,491miR-539-5p targets BMP2 to regulate Treg activation in B-cell acute lymphoblastic leukemia through TGF-β/Smads/MAPK.Exp Biol Med (Maywood)2024https://conductscience.org/library/papers/38510491PubMed
38,059,889MicroRNA 211-5p inhibits cancer cell proliferation and migration in pancreatic cancer by targeting BMP2.Aging (Albany NY)2023https://conductscience.org/library/papers/38059889PubMed

1 to 10 of 14

See all 14 cited by

Genes7

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BMP1649PubTator's text mininghttps://conductscience.org/library/genes/649NCBI Gene
BMP2650PubTator's text mininghttps://conductscience.org/library/genes/650NCBI Gene
CDK21,017PubTator's text mininghttps://conductscience.org/library/genes/1017NCBI Gene
CDK41,019PubTator's text mininghttps://conductscience.org/library/genes/1019NCBI Gene
CDK61,021PubTator's text mininghttps://conductscience.org/library/genes/1021NCBI Gene
EZH22,146PubTator's text mininghttps://conductscience.org/library/genes/2146NCBI Gene
TGFB17,040PubTator's text mininghttps://conductscience.org/library/genes/7040NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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