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Paper · 36235266

Erdafitinib Inhibits Tumorigenesis of Human Lung Adenocarcinoma A549 by Inducing S-Phase Cell-Cycle Arrest as a CDK2 Inhibitor.

Meng X and 9 others. Molecules, 2022. Cited by 14 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Erdafitinib Inhibits Tumorigenesis of Human Lung Adenocarcinoma A549 by Inducing S-Phase Cell-Cycle Arrest as a CDK2 Inhibitor. Papers, record 36235266. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/36235266

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Erdafitinib Inhibits Tumorigenesis of Human Lung Adenocarcinoma A549 by Inducing S-Phase Cell-Cycle Arrest as a CDK2 Inhibitor.
PubMed
Journal
Molecules
PubMed
Year
2022
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
14
iCite
Relative citation ratio, by iCite
1.03
iCite
Revised in PubMed
2024-09-06
PubMed

Authors10

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Meng XXinmin
2Zhu XXue
3Ji JJiali
4Zhong HHongqin
5Li XXiyue
6Zhao HHongqing
7Xie GGuijuan
8Wang KKehttps://orcid.org/0000-0003-3812-7018
9Shu HHong
10Wang XXun

Source PubMed

Topics14

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Adenocarcinoma of LungMajor topic
Lung NeoplasmsMajor topic
Animals
Apoptosis
Carcinogenesis
Cell Cycle
Cell Cycle Checkpoints
Cell Line, Tumor
Cyclin-Dependent Kinase 2
Humans
Mice
Protein Kinase Inhibitors
Pyrazoles
Quinoxalines

Source PubMed

Grants7

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated by
2018GXNSFAA281053Natural Science Fund Project of Guangxi Province of ChinaPubMed
YCSW2022204Innovation Project of Guangxi Graduate EducationPubMed
MS201937Research Project Fund from Wuxi Municipal Health CommissionPubMed
T201937Research Project Fund from Wuxi Municipal Health CommissionPubMed
NOTop-Notch Talents from Health Care in WuxiPubMed
Z202009Major project of Wuxi Commission of HealthPubMed
Z202110Major project of Wuxi Commission of HealthPubMed

Source PubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References42

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
125,383,044Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells.Cancer Cell Int2014https://conductscience.org/library/papers/25383044PubMed
231,810,398Erdafitinib for the treatment of metastatic bladder cancer.Expert Rev Clin Pharmacol2020https://conductscience.org/library/papers/31810398PubMed
332,183,020The Roles of Cyclin-Dependent Kinases in Cell-Cycle Progression and Therapeutic Strategies in Human Breast Cancer.Int J Mol Sci2020https://conductscience.org/library/papers/32183020PubMed
430,061,045CDK4/6 Inhibition in Cancer: Beyond Cell Cycle Arrest.Trends Cell Biol2018https://conductscience.org/library/papers/30061045PubMed
534,557,754Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors.Innovation (Camb)2021https://conductscience.org/library/papers/34557754PubMed
635,053,461The Renaissance of Cyclin Dependent Kinase Inhibitors.Cancers (Basel)2022https://conductscience.org/library/papers/35053461PubMed
726,345,201Inhibition of lung cancer cells A549 and H460 by curcuminoid extracts and nanoemulsions prepared from Curcuma longa Linnaeus.Int J Nanomedicine2015https://conductscience.org/library/papers/26345201PubMed
833,375,902Fibroblast growth factor receptor (FGFR) inhibitors: A review of a novel therapeutic class.J Oncol Pharm Pract2021https://conductscience.org/library/papers/33375902PubMed
927,030,077Treating cancer with selective CDK4/6 inhibitors.Nat Rev Clin Oncol2016https://conductscience.org/library/papers/27030077PubMed
1027,027,665Gene aberrations for precision medicine against lung adenocarcinoma.Cancer Sci2016https://conductscience.org/library/papers/27027665PubMed

1 to 10 of 42

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Cited by9

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 14 citations.

PMIDTitleJournalYearIn PapersSource
40,685,347EMP3 is upregulated upon epithelial-mesenchymal transition and contributes to EGFR-tyrosine kinase inhibitor resistance in lung adenocarcinoma.Eur J Med Res2025https://conductscience.org/library/papers/40685347PubMed
40,635,078Erdafitinib inhibits the tumorigenicity of MDA-MB-231 triple-negative breast cancer cells by inducing TRIM25/ubiquitin-dependent degradation of FGFR4.Breast Cancer Res2025https://conductscience.org/library/papers/40635078PubMed
40,538,537Erdafitinib diminishes LPS-mediated neuroinflammatory responses through NLRP3 in wild-type mice.Front Pharmacol2025https://conductscience.org/library/papers/40538537PubMed
40,521,477Unraveling Structural and Anticancer Properties of Pyridine-Oxadiazole Derivatives: Single-Crystal XRD, Hirshfeld Analysis, and Cytotoxicity against A549 Cells.ACS Omega2025https://conductscience.org/library/papers/40521477PubMed
40,170,083The TEAD4-DYNLL1 axis accelerates cell cycle progression and augments malignant properties of lung adenocarcinoma cells.Eur J Med Res2025https://conductscience.org/library/papers/40170083PubMed
40,001,320A Comprehensive Analysis of FGF/FGFR Signaling Alteration in NSCLC: Implications in Prognosis and Microenvironment.Thorac Cancer2025https://conductscience.org/library/papers/40001320PubMed
39,994,286Design, synthesis and pharmacological evaluation of 1,4-naphthoquinone- 1,2,3-triazole hybrids as new anticancer agents with multi-kinase inhibitory activity.Sci Rep2025https://conductscience.org/library/papers/39994286PubMed
39,247,610STAT3 inhibitor Stattic Exhibits the Synergistic Effect with FGFRs Inhibitor Erdafitinib in FGFR1-positive Lung Squamous Cell Carcinoma.J Cancer2024https://conductscience.org/library/papers/39247610PubMed
37,994,663
New spiro-indeno[1,2-b]quinoxalines clubbed with benzimidazole scaffold as CDK2 inhibitors for halting non-small cell lung cancer; stereoselective synthesis, molecular dynamics and structural insights.
J Enzyme Inhib Med Chem2023https://conductscience.org/library/papers/37994663PubMed

Genes12

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
ANXA5308PubTator's text mininghttps://conductscience.org/library/genes/308NCBI Gene
CDK1983PubTator's text mininghttps://conductscience.org/library/genes/983NCBI Gene
CDK1251,755PubTator's text mininghttps://conductscience.org/library/genes/51755NCBI Gene
CDK21,017PubTator's text mininghttps://conductscience.org/library/genes/1017NCBI Gene
E2F11,869PubTator's text mininghttps://conductscience.org/library/genes/1869NCBI Gene
EGFR1,956PubTator's text mininghttps://conductscience.org/library/genes/1956NCBI Gene
FGFR12,260PubTator's text mininghttps://conductscience.org/library/genes/2260NCBI Gene
FGFR22,263PubTator's text mininghttps://conductscience.org/library/genes/2263NCBI Gene
FGFR32,261PubTator's text mininghttps://conductscience.org/library/genes/2261NCBI Gene
GAPDH2,597PubTator's text mininghttps://conductscience.org/library/genes/2597NCBI Gene

1 to 10 of 12

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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