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Paper · 37895166

RETRACTED: Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity.

Mannino F and 10 others. Int J Mol Sci, 2023. Cited by 7 papers, by iCite. Retracted.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. RETRACTED: Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity. Papers, record 37895166. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/37895166

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
RETRACTED: Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity.
PubMed
Journal
Int J Mol Sci
PubMed
Year
2023
PubMed
Publication types
Journal Article, Retracted Publication
PubMed
Citations, by iCite
7
iCite
Relative citation ratio, by iCite
1.54
iCite
Retracted
Yes, by PubMed's record
PubMed
Revised in PubMed
2026-01-27
PubMed

Authors11

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Mannino FFederica
2Pallio GGiovannihttps://orcid.org/0000-0002-4187-2265
3Imbesi CChiara
4Scarfone AAlessandro
5Puzzolo DDomenico
6Micali AAntonio
7Freni JJoséhttps://orcid.org/0000-0001-7855-2655
8Squadrito FFrancescohttps://orcid.org/0000-0002-8868-0762
9Bitto AAlessandra
10Minutoli LLetteria

1 to 10 of 11Source PubMed

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Topics11

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
SesquiterpenesMajor topic
NeuroblastomaMajor topic
Humans
Cadmium
Receptor, Cannabinoid, CB2
Reactive Oxygen Species
Antioxidants
NF-E2-Related Factor 2
Anti-Inflammatory Agents, Non-Steroidal
Cell Line, Tumor
Polycyclic Sesquiterpenes

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections1

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

KindPMIDTitleIn Papers
Retracted by40,076,995RETRACTED: Mannino et al. Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity. Int. J. Mol. Sci. 2023, 24, 15487.https://conductscience.org/library/papers/40076995

Source PubMed

References47

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
126,773,363Curcumin and β-caryophellene attenuate cadmium quantum dots induced oxidative stress and lethality in Caenorhabditis elegans model system.Environ Toxicol Pharmacol2016https://conductscience.org/library/papers/26773363PubMed
223,931,748Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum.Cell Metab2013https://conductscience.org/library/papers/23931748PubMed
332,466,586The Effects of Cadmium Toxicity.Int J Environ Res Public Health2020https://conductscience.org/library/papers/32466586PubMed
425,022,246The protective effect of Physalis peruviana L. against cadmium-induced neurotoxicity in rats.Biol Trace Elem Res2014https://conductscience.org/library/papers/25022246PubMed
531,468,353Possible prophylactic effect of omega-3 fatty acids on cadmium-induced neurotoxicity in rats' brains.Environ Sci Pollut Res Int2019https://conductscience.org/library/papers/31468353PubMed
618,281,164Mechanism of cadmium induced apoptosis in the immunocyte.Toxicol Lett2008https://conductscience.org/library/papers/18281164PubMed
735,318,111Potential protective effect of beta-caryophyllene against cadmium chloride-induced damage to the male reproductive system in mouse.Reprod Toxicol2022https://conductscience.org/library/papers/35318111PubMed
822,945,569Heavy metal toxicity and the environment.Exp Suppl2012https://conductscience.org/library/papers/22945569PubMed
934,311,536PDRN, a natural bioactive compound, blunts inflammation and positively reprograms healing genes in an "in vitro" model of oral mucositis.Biomed Pharmacother2021https://conductscience.org/library/papers/34311536PubMed
1012,813,001Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.Br J Pharmacol2003https://conductscience.org/library/papers/12813001PubMed

1 to 10 of 47

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Cited by7

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 7 citations.

PMIDTitleJournalYearIn PapersSource
41,160,374Beta-Caryophyllene Mitigates Oxidative Stress in Skin Fibroblasts by Targeting mTOR, Akt, and MAPK Signaling.Cell Biochem Biophys2026https://conductscience.org/library/papers/41160374PubMed
40,076,995RETRACTED: Mannino et al. Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity. Int. J. Mol. Sci. 2023, 24, 15487.Int J Mol Sci2025https://conductscience.org/library/papers/40076995PubMed
39,968,054ADME/Tox study and the effect of β-Caryophyllene on the resistant strain of Staphylococcus aureus carrying the QacA/B efflux pump gene.Toxicol Rep2025https://conductscience.org/library/papers/39968054PubMed
39,717,553Activation of cannabinoid receptor 2 by turmeric oleoresin reduces inflammation and oxidative stress in an osteoarthritis in vitro model.Front Pharmacol2024https://conductscience.org/library/papers/39717553PubMed
39,125,623Evaluation of the Potential Cytoprotective Effect of Melatonin in Comparison with Vitamin E and Trolox against Cd2+-Induced Toxicity in SH-SY5Y, HCT 116, and HepG2 Cell Lines.Int J Mol Sci2024https://conductscience.org/library/papers/39125623PubMed
38,543,118Effect of Arthrospira (Spirulina) maxima on Cadmium-Chloride-Induced Alterations in Sexual Behavior and Fertility in Male Wistar Rats.Pharmaceuticals (Basel)2024https://conductscience.org/library/papers/38543118PubMed
38,338,554Evaluation of the Potential Protective Effect of Ellagic Acid against Heavy Metal (Cadmium, Mercury, and Lead) Toxicity in SH-SY5Y Neuroblastoma Cells.Foods2024https://conductscience.org/library/papers/38338554PubMed

Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
BAX581PubTator's text mininghttps://conductscience.org/library/genes/581NCBI Gene
BCL2596PubTator's text mininghttps://conductscience.org/library/genes/596NCBI Gene
BDNF627PubTator's text mininghttps://conductscience.org/library/genes/627NCBI Gene
CNR11,268PubTator's text mininghttps://conductscience.org/library/genes/1268NCBI Gene
CTRL1,506PubTator's text mininghttps://conductscience.org/library/genes/1506NCBI Gene
DNTT1,791PubTator's text mininghttps://conductscience.org/library/genes/1791NCBI Gene
IL1B3,553PubTator's text mininghttps://conductscience.org/library/genes/3553NCBI Gene
IL63,569PubTator's text mininghttps://conductscience.org/library/genes/3569NCBI Gene
NFE2L24,780PubTator's text mininghttps://conductscience.org/library/genes/4780NCBI Gene
NFKB14,790PubTator's text mininghttps://conductscience.org/library/genes/4790NCBI Gene

1 to 10 of 13

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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