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Paper · 38643262

TMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts.

Stefania K and 4 others. Sci Rep, 2024. Cited by 38 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. TMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts. Papers, record 38643262. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/38643262

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
TMAO enhances TNF-α mediated fibrosis and release of inflammatory mediators from renal fibroblasts.
PubMed
Journal
Sci Rep
PubMed
Year
2024
PubMed
Publication types
Journal Article
PubMed
Citations, by iCite
38
iCite
Relative citation ratio, by iCite
6.59, provisional
iCite
Revised in PubMed
2024-04-26
PubMed

Authors5

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Stefania KKapetanaki
2Ashok KKKumawat Kumar
3Geena PVParamel Varghese
4Katarina PPersson
5Isak DDemirel

Source PubMed

Topics10

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Tumor Necrosis Factor-alphaMajor topic
Renal Insufficiency, ChronicMajor topic
MethylaminesMajor topic
Humans
Inflammation Mediators
Fibrosis
Cytokines
Fibroblasts
Inflammation
Collagen

Source PubMed

Grants0

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

None in this release.

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References61

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
133,436,815Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.Sci Rep2021https://conductscience.org/library/papers/33436815PubMed
235,729,842The role of IL-10 in kidney disease.Int Immunopharmacol2022https://conductscience.org/library/papers/35729842PubMed
322,009,250Cellular and molecular mechanisms of renal fibrosis.Nat Rev Nephrol2011https://conductscience.org/library/papers/22009250PubMed
434,769,294The Fibrotic Effects of TMAO on Human Renal Fibroblasts Is Mediated by NLRP3, Caspase-1 and the PERK/Akt/mTOR Pathway.Int J Mol Sci2021https://conductscience.org/library/papers/34769294PubMed
536,195,887TNFα and IFNγ rapidly activate PI3K-AKT signaling to drive glycolysis that confers mesenchymal stem cells enhanced anti-inflammatory property.Stem Cell Res Ther2022https://conductscience.org/library/papers/36195887PubMed
618,508,599Urokinase and its receptors in chronic kidney disease.Front Biosci2008https://conductscience.org/library/papers/18508599PubMed
716,951,369Distinct in vivo roles of colony-stimulating factor-1 isoforms in renal inflammation.J Immunol2006https://conductscience.org/library/papers/16951369PubMed
87,773,632Human renal fibroblast cell lines (tFKIF and tNKF) are new tools to investigate pathophysiologic mechanisms of renal interstitial fibrosis.Exp Nephrol1995https://conductscience.org/library/papers/7773632PubMed
920,502,043The role of tubulointerstitial inflammation in the progression of chronic renal failure.Nephron Clin Pract2010https://conductscience.org/library/papers/20502043PubMed
1032,365,994The Role of Wnt Signalling in Chronic Kidney Disease (CKD).Genes (Basel)2020https://conductscience.org/library/papers/32365994PubMed

1 to 10 of 61

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Cited by30

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 38 citations.

PMIDTitleJournalYearIn PapersSource
42,589,363Intestinal Flora and Myocarditis: Potential Mechanisms and Therapeutic Strategies Affecting Disease Progression and Cardiac Function.Int J Mol Sci2026https://conductscience.org/library/papers/42589363PubMed
42,495,760Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review).Int J Mol Med2026https://conductscience.org/library/papers/42495760PubMed
42,239,940Trimethylamine N-Oxide Combined with Phenylacetylglutamine as Potential Biomarkers for Diabetic Kidney Disease.Diabetes Metab Syndr Obes2026https://conductscience.org/library/papers/42239940PubMed
42,008,043Targeting YAP: mechanistic breakthroughs and therapeutic prospects in reversing organ fibrosis.Mol Cell Biochem2026https://conductscience.org/library/papers/42008043PubMed
41,674,334Applying dendrimer nanoprobes to the diagnosis and evaluation of kidney fibrosis.Nanomedicine (Lond)2026https://conductscience.org/library/papers/41674334PubMed
41,632,330IFN-γ and TNF-α Impair Lung Development by Upregulating SMAD7 to Inhibit TGF-β Signaling Pathway and ECM Dysregulation.Inflammation2026https://conductscience.org/library/papers/41632330PubMed
41,628,781Gut microbiota-derived metabolites as immune modulators in aging and age-related chronic inflammatory diseases.Ageing Res Rev2026https://conductscience.org/library/papers/41628781PubMed
41,522,487The Gut Microbiota-Insulin Resistance Axis: Mechanisms, Clinical Implications, and Therapeutic Potential.FASEB Bioadv2026https://conductscience.org/library/papers/41522487PubMed
41,453,954Trimethylamine-N-oxide promotes fibrotic activation of quiescent valvular interstitial cells via endoplasmic reticulum stress.Sci Rep2025https://conductscience.org/library/papers/41453954PubMed
41,441,627Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease.Toxins (Basel)2025https://conductscience.org/library/papers/41441627PubMed

1 to 10 of 30

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Genes13

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AKT1207PubTator's text mininghttps://conductscience.org/library/genes/207NCBI Gene
CCL76,354PubTator's text mininghttps://conductscience.org/library/genes/6354NCBI Gene
CD40958PubTator's text mininghttps://conductscience.org/library/genes/958NCBI Gene
CXCL66,372PubTator's text mininghttps://conductscience.org/library/genes/6372NCBI Gene
FN12,335PubTator's text mininghttps://conductscience.org/library/genes/2335NCBI Gene
HGF3,082PubTator's text mininghttps://conductscience.org/library/genes/3082NCBI Gene
IL63,569PubTator's text mininghttps://conductscience.org/library/genes/3569NCBI Gene
LAP7,939PubTator's text mininghttps://conductscience.org/library/genes/7939NCBI Gene
MAPK15,594PubTator's text mininghttps://conductscience.org/library/genes/5594NCBI Gene
MTOR2,475PubTator's text mininghttps://conductscience.org/library/genes/2475NCBI Gene

1 to 10 of 13

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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