Disease · EFO_0022985
neonatal encephalopathy
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. neonatal encephalopathy. Diseases, record EFO_0022985. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/EFO_0022985
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- neonatal encephalopathy
- Open Targets ID
- EFO_0022985
- Highest stage of its drugs
- Phase 3, for 3 of its 7 drugs, from ClinicalTrials.gov
Source Open Targets
Drugs7
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| DARBEPOETIN ALFA | CHEMBL1201566 | Protein | Phase 3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| EPOETIN ALFA | CHEMBL1201565 | Protein | Phase 3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| EPOETIN BETA | CHEMBL2109092 | Protein | Phase 3 | ClinicalTrials.gov | 1 | 1 | 0 | Drugs and targets |
| DEXMEDETOMIDINE HYDROCHLORIDE | CHEMBL2106195 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| MORPHINE SULFATE | CHEMBL2103744 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SOVATELITIDE | CHEMBL3188091 | Protein | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SILDENAFIL | CHEMBL192 | Small molecule | Phase 1 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
Targets6
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| EPOR | Erythropoietin receptor | 3 | Erythropoietin receptor agonist | Phase 3 | https://conductscience.org/library/genes/2057 | Drugs and targets |
| ADRA2A | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/150 | Drugs and targets |
| ADRA2B | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/151 | Drugs and targets |
| ADRA2C | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 agonist | Phase 2 | https://conductscience.org/library/genes/152 | Drugs and targets |
| OPRM1 | Mu-type opioid receptor | 1 | Mu opioid receptor agonist | Phase 2 | https://conductscience.org/library/genes/4988 | Drugs and targets |
| PDE5A | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 | Phosphodiesterase 5A inhibitor | Phase 1 | https://conductscience.org/library/genes/8654 | Drugs and targets |
Trials4
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT04772222 | Dexmedetomidine Use in Infants Undergoing Cooling Due to Neonatal Encephalopathy (DICE Trial) | Phase 2 | 50 | 2026-03-06 | Hypoxic-Ischemic Encephalopathy, Pain | DEXMEDETOMIDINE HYDROCHLORIDE, MORPHINE SULFATE | Its record names the disease | ClinicalTrials.gov |
| NCT05514340 | Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy | Phase 2 | 40 | Hypoxic-Ischemic Encephalopathy, Neonatal Asphyxia, Neonatal Encephalopathy | SOVATELITIDE | Its record names the disease | ClinicalTrials.gov | |
| NCT02812433 | Sildenafil Administration to Treat Neonatal Encephalopathy | Phase 1 | 28 | Neonatal Encephalopathy | SILDENAFIL | Its record names the disease | ClinicalTrials.gov | |
| NCT05275725 | Finding Solutions to Thrive After Birth Asphyxia in Africa | Phase 1 | 18 | Birth Asphyxia | SILDENAFIL | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials3
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Dexmedetomidine (DMT) vs Morphine: Number of Participants Who Experience Shivering | 13 of 25 | 14 of 23 | 48 | NCT04772222 | Trial comparisons |
| Dexmedetomidine (DMT) vs Morphine: deaths from any cause | 0 of 25 | 1 of 23 | 48 | NCT04772222 | Trial comparisons |
| Dexmedetomidine (DMT) vs Morphine: serious adverse events | 1 of 25 | 1 of 23 | 48 | NCT04772222 | Trial comparisons |
Papers from its trials2
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/EFO_0022985
GET https://conductscience.org/api/diseases/v1/EFO_0022985/drugs