Disease · GO_0030728
ovulation
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. ovulation. Diseases, record GO_0030728. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/GO_0030728
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- ovulation
- Open Targets ID
- GO_0030728
- Highest stage of its drugs
- Approval, for 1 of its 14 drugs, from EMA Human Drugs
Source Open Targets
Drugs14
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| CETRORELIX | CHEMBL1200490 | Protein | Approval | EMA Human Drugs | 1 | 0 | 0 | Drugs and targets |
| ESTRADIOL | CHEMBL135 | Small molecule | Phase 2 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| ETHINYL ESTRADIOL | CHEMBL691 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ETONOGESTREL | CHEMBL1531 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| IBUPROFEN | CHEMBL521 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| LEVONORGESTREL | CHEMBL1389 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| MELOXICAM | CHEMBL599 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| NOMEGESTROL ACETATE | CHEMBL1476022 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| PIROXICAM | CHEMBL527 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| ULIPRISTAL ACETATE | CHEMBL260538 | Small molecule | Phase 1/2 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
1 to 10 of 14
See all 14 drugsTargets6
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| PGR | Progesterone receptor | 6 | Progesterone receptor agonist; Progesterone receptor modulator | Phase 2 | https://conductscience.org/library/genes/5241 | Drugs and targets |
| ESR1 | Estrogen receptor | 3 | Estrogen receptor alpha agonist; Estrogen receptor modulator | Phase 2 | https://conductscience.org/library/genes/2099 | Drugs and targets |
| PTGS2 | Cyclooxygenase | 3 | Cyclooxygenase inhibitor; Cyclooxygenase-2 inhibitor | Phase 2 | https://conductscience.org/library/genes/5743 | Drugs and targets |
| GNRHR | Gonadotropin-releasing hormone receptor | 2 | Gonadotropin-releasing hormone receptor antagonist | Approval | https://conductscience.org/library/genes/2798 | Drugs and targets |
| PTGS1 | Cyclooxygenase | 2 | Cyclooxygenase inhibitor | Phase 2 | https://conductscience.org/library/genes/5742 | Drugs and targets |
| ESR2 | Estrogen receptor | 1 | Estrogen receptor modulator | Phase 1 | https://conductscience.org/library/genes/2100 | Drugs and targets |
Trials10
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT01709318 | A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012) | Phase 2 | 666 | 2019-12-05 | Contraception | ESTRADIOL, ETHINYL ESTRADIOL, ETONOGESTREL, NOMEGESTROL ACETATE | Its record names the disease | ClinicalTrials.gov |
| NCT04291001 | Ovarian Function With ENG Implant and UPA Use | Early phase 1 | 40 | 2024-07-12 | Contraception | ULIPRISTAL ACETATE | Its record names the disease | ClinicalTrials.gov |
| NCT01403038 | An Open-label Study of the Effects of Elagolix in Adult Premenopausal Females | Phase 1 | 216 | Folliculogenesis | ELAGOLIX | Its record names the disease | ClinicalTrials.gov | |
| NCT01320709 | Effect of Piroxicam on Ovulation | Phase 2 | 72 | Contraception, Postcoital | PIROXICAM | Its record names the disease | ClinicalTrials.gov | |
| NCT02732418 | Lower Dose Depo Provera® Contraceptive Injection | Phase 1 | 60 | Contraception | MEDROXYPROGESTERONE ACETATE | Its record names the disease | ClinicalTrials.gov | |
| NCT02571543 | Can Ibuprofen Delay Ovulation in Natural Cycle-IVF? | Phase 2 | 51 | Ovulation, Ovulation Inhibition, Ovulation Inhibition/Drug Effects, Pregnancy, Fertilization in Vitro/Methods | IBUPROFEN | Its record names the disease | ClinicalTrials.gov | |
| NCT03343912 | Estriol and Trimegestone Dose-response Trial With Single Dose Application of Vaginal Rings | Phase 1 | 36 | Pregnancy | ESTRIOL, TRIMEGESTONE | Its record names the disease | ClinicalTrials.gov | |
| NCT02451826 | A Study to Evaluate the Effect of a Contraceptive Vaginal Ring Delivering Ulipristal Acetate Combined With a Single or Repeated Levonorgestrel on Inhibition of Ovulation, Endometrial Changes and Bleeding Patterns in Normal Cycling Women | Phase 1/2 | 19 | Ovulation Inhibition | ULIPRISTAL ACETATE | Its record names the disease | ClinicalTrials.gov | |
| NCT05695352 | Oral Levonorgestrel Plus Meloxicam, IG-002 Delays Ovulation in Normal Menstruating Women by Seven Days | Phase 2 | 19 | Pregnancy Prevention | LEVONORGESTREL, MELOXICAM | Its record names the disease | ClinicalTrials.gov | |
| NCT00796133 | A Phase 2, Dose-finding, Cross-over Study to Evaluate the Effect of a NES/E2 Transdermal Gel Delivery on Ovulation Suppression in Normal Ovulating Women | Phase 2 | 18 | Ovulation | ESTRADIOL | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials2
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| ENG Implant Alone vs ENG Implant Plus Oral UPA: deaths from any cause | 0 of 20 | 0 of 20 | 40 | NCT04291001 | Trial comparisons |
| ENG Implant Alone vs ENG Implant Plus Oral UPA: serious adverse events | 0 of 20 | 0 of 20 | 40 | NCT04291001 | Trial comparisons |
Papers from its trials18
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/GO_0030728
GET https://conductscience.org/api/diseases/v1/GO_0030728/drugs