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Disease · HP_0001788

Premature rupture of membranes

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. Premature rupture of membranes. Diseases, record HP_0001788. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0001788

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
Premature rupture of membranes
Open Targets ID
HP_0001788
Highest stage of its drugs
Phase 3, for 2 of its 3 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs3

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
OXYTOCINCHEMBL395429ProteinPhase 3ClinicalTrials.gov666Drugs and targets
DINOPROSTONECHEMBL548Small moleculePhase 3ClinicalTrials.gov333Drugs and targets
MISOPROSTOLCHEMBL606Small moleculeUnknownClinicalTrials.gov222Drugs and targets

Targets5

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
PTGER3Prostaglandin E2 receptor2Prostaglandin E2 receptor agonist; Prostanoid EP3 receptor agonistPhase 3https://conductscience.org/library/genes/5733Drugs and targets
OXTROxytocin receptor1Oxytocin receptor agonistPhase 3https://conductscience.org/library/genes/5021Drugs and targets
PTGER1Prostaglandin E2 receptor1Prostaglandin E2 receptor agonistPhase 3https://conductscience.org/library/genes/5731Drugs and targets
PTGER2Prostaglandin E2 receptor1Prostaglandin E2 receptor agonistPhase 3https://conductscience.org/library/genes/5732Drugs and targets
PTGER4Prostaglandin E2 receptor1Prostaglandin E2 receptor agonistPhase 3https://conductscience.org/library/genes/5734Drugs and targets

Trials7

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT02314728Cervical Ripening in Premature Rupture of MembranesNot applicable2302021-08-10Pregnancy, Premature Rupture of Membranes, Preterm Premature Rupture of Membranes, Unfavorable CervixMISOPROSTOL, OXYTOCINIts record names the diseaseClinicalTrials.gov
NCT01973036FOLCROM Trial: Foley Catheter in Rupture of MembranesNot applicable2012018-09-24Premature Rupture of MembranesOXYTOCINIts record names the diseaseClinicalTrials.gov
NCT01736852Evaluation of CRB in PROM PatientsNot applicable1292020-10-20Premature Rupture of Fetal MembranesOXYTOCINIts record names the diseaseClinicalTrials.gov
NCT02720978Tearing of Membranes Before Birth - a Comparison Between Two Ways of Induction of Labor Pitocin Opposite ProstaglandinPhase 31,200Fetus or Newborn or Maternal; Effects of Induction of LaborDINOPROSTONE, OXYTOCINIts record names the diseaseClinicalTrials.gov
NCT02825641Premature Rupture of Membranes With a Bishop Score<6: Comparison of Medical Induction/Expectant ManagementNot applicable458Medical Induction of Labor Affecting NewbornDINOPROSTONE, OXYTOCINIts record names the diseaseClinicalTrials.gov
NCT04143685Labor Induction With Misoprostol Versus Oxytocin in Women With Premature Rupture of MembranesNot applicable200Prelabor Rupture of Membranes, Premature Rupture of MembraneMISOPROSTOL, OXYTOCINIts record names the diseaseClinicalTrials.gov
NCT01916291Safety and Efficacy of Dinoprostone (Propess) in the Women With Premature Rupture of Membrane or Gestational Age <38Phase 2189Induction of LaborDINOPROSTONEOpen Targets' reading of its recordClinicalTrials.gov

Comparisons in its trials17

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Misoprostol vs Oxytocin Alone: deaths from any cause0 of 1170 of 113230NCT02314728Trial comparisons
Misoprostol vs Oxytocin Alone: serious adverse events0 of 1170 of 113230NCT02314728Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Overall Cesarean Delivery21 of 10825 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Rate of Neonatal Sepsis0 of 1080 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Number of Participants With Vaginal Delivery Within 12 Hours From Placement of Foley Catheter or Start Time of Oxytocin46 of 10834 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Rate of Five Minute Apgar Score < 51 of 1081 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Number of Participants With Confirmed Histologic Chorioamnionitis/Funisitis9 of 10810 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Rate of Chorioamnionitis0 of 1087 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Rate of Endomyometritis0 of 1080 of 93201NCT01973036Trial comparisons
Oxytocin vs Foley Catheter and Oxytocin: Neonatal Intensive Care Unit (NICU) Admission Rate20 of 10821 of 93201NCT01973036Trial comparisons

1 to 10 of 17

See all 17 comparisons in its trials

Papers from its trials22

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
24297389RESULT1PubMed
22105253RESULT1PubMed
21793769RESULT1PubMed
21152844RESULT1PubMed
21087166RESULT1PubMed
19384121RESULT1PubMed
18515515RESULT1PubMed
16753768RESULT1PubMed
16437525RESULT1PubMed
16125041RESULT1PubMed

1 to 10 of 22

See all 22 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0001788

GET https://conductscience.org/api/diseases/v1/HP_0001788/papers?page=2

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