Disease · HP_0012227

Urethral stricture

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. Urethral stricture. Diseases, record HP_0012227. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/HP_0012227

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: Urethral stricture
Open Targets ID: HP_0012227
Highest stage of its drugs: Phase 2/3, for 1 of its 2 drugs, from ClinicalTrials.gov

Source Open Targets

Drugs2

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
MITOMYCIN	CHEMBL105	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	CHEMBL2108709	Enzyme	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets25

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
COL11A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1301	Drugs and targets
COL11A2	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1302	Drugs and targets
COL15A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1306	Drugs and targets
COL18A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/80781	Drugs and targets
COL1A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1277	Drugs and targets
COL1A2	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1278	Drugs and targets
COL24A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/255631	Drugs and targets
COL27A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/85301	Drugs and targets
COL28A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/340267	Drugs and targets
COL2A1	Collagen	1	Collagen hydrolytic enzyme	Phase 2	https://conductscience.org/library/genes/1280	Drugs and targets

1 to 10 of 25

See all 25 targets

Trials2

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT02948842	Clostridium Histolyticum Collagenase Injection for Urethral Disease	Phase 2	5	2023-11-03	Urethral Stricture	COLLAGENASE CLOSTRIDIUM HISTOLYTICUM	Its record names the disease	ClinicalTrials.gov
NCT06232005	Intralesional Injection of Mitomycin C Following Visual Internal Urethrotomy for Recurrent Urethral Stricture	Phase 2/3	50		Urethral Stricture	MITOMYCIN	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials9

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
26491251	RESULT	1	PubMed
26126692	RESULT	1	PubMed
24745607	RESULT	1	PubMed
23376148	RESULT	1	PubMed
21315996	RESULT	1	PubMed
17617144	RESULT	1	PubMed
17437780	RESULT	1	PubMed
15541123	RESULT	1	PubMed
9679876	RESULT	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/HP_0012227

GET https://conductscience.org/api/diseases/v1/HP_0012227/targets?page=2

API reference For AI assistants