Disease · MONDO_0001566

hypercalcemia disease

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. hypercalcemia disease. Diseases, record MONDO_0001566. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0001566

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: hypercalcemia disease; Open Targets
Open Targets ID: MONDO_0001566; Open Targets
Other names: Elevated calcium(2+) concentration, Elevated calcium(2+) level, Elevated calcium(2+) level in blood, High blood calcium levels, Hypercalcaemia, Increased calcium in blood, Increased calcium(2+) concentration, Increased calcium(2+) level, Increased calcium(2+) level in blood, hypercalcemia; Open Targets
Disease Ontology: DOID:12678; Disease Ontology
MeSH: D006934; MeSH
NCI Thesaurus: C3112; NCI Thesaurus
Highest stage of its drugs: Approval, for 15 of its 18 drugs, from DailyMed, EMA Human Drugs, FDA, PMDA and TTD; Open Targets

Drugs18

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CINACALCET	CHEMBL1201284	Small molecule	Approval	EMA Human Drugs	6	3	3	Drugs and targets
IBANDRONIC ACID	CHEMBL997	Small molecule	Approval	EMA Human Drugs	4	0	0	Drugs and targets
ZOLEDRONIC ACID	CHEMBL4303669	Small molecule	Approval	EMA Human Drugs and PMDA	3	0	0	Drugs and targets
CALCITONIN SALMON	CHEMBL3989767	Protein	Approval	FDA	2	0	0	Drugs and targets
CORTISONE ACETATE	CHEMBL1650	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
DEXAMETHASONE	CHEMBL384467	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
DEXAMETHASONE SODIUM PHOSPHATE	CHEMBL2021430	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
CLODRONIC ACID	CHEMBL12318	Small molecule	Approval	TTD	1	0	0	Drugs and targets
DENOSUMAB	CHEMBL1237023	Antibody	Approval	DailyMed	1	0	0	Drugs and targets
GALLIUM NITRATE	CHEMBL1200983	Small molecule	Approval	TTD	1	0	0	Drugs and targets

1 to 10 of 18

See all 18 drugs

Targets8

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	5	Glucocorticoid receptor agonist	Approval	https://conductscience.org/library/genes/2908	Drugs and targets
FDPS	Farnesyl pyrophosphate synthase	4	Farnesyl diphosphate synthase inhibitor	Approval	https://conductscience.org/library/genes/2224	Drugs and targets
CASR	Extracellular calcium-sensing receptor	2	Calcium sensing receptor positive allosteric modulator	Approval	https://conductscience.org/library/genes/846	Drugs and targets
CALCR	Calcitonin receptor	1	Calcitonin receptor agonist	Approval	https://conductscience.org/library/genes/799	Drugs and targets
RRM1	Ribonucleoside-diphosphate reductase RR1	1	Ribonucleoside-diphosphate reductase RR1 inhibitor	Approval	https://conductscience.org/library/genes/6240	Drugs and targets
RRM2	Ribonucleoside-diphosphate reductase RR1	1	Ribonucleoside-diphosphate reductase RR1 inhibitor	Approval	https://conductscience.org/library/genes/6241	Drugs and targets
RRM2B	Ribonucleoside-diphosphate reductase RR1	1	Ribonucleoside-diphosphate reductase RR1 inhibitor	Approval	https://conductscience.org/library/genes/50484	Drugs and targets
TNFSF11	Tumor necrosis factor ligand superfamily member 11	1	Tumor necrosis factor ligand superfamily member 11 inhibitor	Approval	https://conductscience.org/library/genes/8600	Drugs and targets

Trials5

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 1 more is not shown, since the checks do not confirm it.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00975000	Treatment of Autonomous Hyperparathyroidism in Post Renal Transplant Recipients	Phase 3	114	2016-01-29	Chronic Allograft Nephropathy, Chronic Kidney Disease, Chronic Renal Failure, Disordered Mineral Metabolism, End Stage Renal Disease, Hyperparathyroidism, Hypophosphatemia, Kidney Disease, Kidney Transplantation, Post Renal Transplantation	CINACALCET	Its record names the disease	ClinicalTrials.gov
NCT00975221	Efficacy and Safety Study of Cinacalcet for the Treatment of Hypercalcemia in Patients With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy	Phase 3	67	2016-01-25	Hyperparathyroidism, Primary, Hypercalcemia	CINACALCET	Its record names the disease	ClinicalTrials.gov
NCT03280264	Phase 3 Study of KHK7580 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Primary Hyperparathyroidism	Phase 3	18	2021-05-27	Parathyroid Carcinoma, Primary Hyperparathyroidism	EVOCALCET	Its record names the disease	ClinicalTrials.gov
NCT03301038	Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria	Phase 2	60		Idiopathic Infantile Hypercalcaemia - Severe Form, Genetic Disease, Hypercalcemia, Idiopathic, of Infancy, Hypercalciuric Hypercalcemia, Idiopathic Infantile Hypercalcemia - Mild Form, Hypercalciuria	RIFAMPIN	Its record names the disease	ClinicalTrials.gov
NCT01460030	An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism	Phase 3			Parathyroid Carcinoma, Hypercalcemia, Primary Hyperparathyroidism	CINACALCET	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Cinacalcet vs Placebo: serious adverse events	15 of 57	19 of 57	114	NCT00975000

Source Trial comparisons

Papers from its trials0

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0001566

GET https://conductscience.org/api/diseases/v1/MONDO_0001566/drugs

API reference For AI assistants