Disease · MONDO_0004277

gonorrhea

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. gonorrhea. Diseases, record MONDO_0004277. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0004277

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: gonorrhea; Open Targets
Open Targets ID: MONDO_0004277; Open Targets
Other names: GC, Neisseria gonorrhoeae infection, chronic gonococcal infectious disease of lower genitourinary tract; Open Targets
Disease Ontology: DOID:7551; Disease Ontology
MeSH: D006069; MeSH
NCI Thesaurus: C92950; NCI Thesaurus
Orphanet: ORPHA:100642; Orphanet
Highest stage of its drugs: Approval, for 9 of its 15 drugs, from DailyMed, PMDA and TTD; Open Targets

Drugs15

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
AZITHROMYCIN	CHEMBL529	Small molecule	Approval	PMDA	3	2	2	Drugs and targets
CEFIXIME	CHEMBL1541	Small molecule	Approval	DailyMed	3	1	1	Drugs and targets
CIPROFLOXACIN	CHEMBL8	Small molecule	Approval	DailyMed	3	1	1	Drugs and targets
DOXYCYCLINE	CHEMBL1200699	Small molecule	Approval	DailyMed	2	1	1	Drugs and targets
CEFTRIAXONE SODIUM	CHEMBL6067656	Small molecule	Approval	DailyMed	38	0	0	Drugs and targets
AMOXICILLIN	CHEMBL1082	Small molecule	Approval	DailyMed	3	0	0	Drugs and targets
AMPICILLIN	CHEMBL174	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
CEFOTAXIME SODIUM	CHEMBL1010	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
ROSARAMICIN	CHEMBL8965	Small molecule	Approval	TTD	1	0	0	Drugs and targets
CEFTRIAXONE	CHEMBL161	Small molecule	Phase 3	ClinicalTrials.gov	4	4	4	Drugs and targets

1 to 10 of 15

See all 15 drugs

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
MMP1	Interstitial collagenase	1	Matrix metalloproteinase-1 inhibitor	Approval	https://conductscience.org/library/genes/4312	Drugs and targets
MMP13	Collagenase 3	1	Matrix metalloproteinase 13 inhibitor	Approval	https://conductscience.org/library/genes/4322	Drugs and targets
MMP7	Matrilysin	1	Matrix metalloproteinase 7 inhibitor	Approval	https://conductscience.org/library/genes/4316	Drugs and targets
MMP8	Neutrophil collagenase	1	Matrix metalloproteinase 8 inhibitor	Approval	https://conductscience.org/library/genes/4317	Drugs and targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04010539	A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea	Phase 3	628	2024-05-30	Gonorrhea	AZITHROMYCIN, CEFTRIAXONE, GEPOTIDACIN	Its record names the disease	ClinicalTrials.gov
NCT02015637	Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea	Phase 3	460	2018-04-26	Gonorrhea	CEFTRIAXONE, DELAFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT02257918	Randomized, Open-label Phase 2 Study of Oral AZD0914 in the Treatment of Gonorrhea	Phase 2	180	2017-02-08	Gonorrhoea	ZOLIFLODACIN	Its record names the disease	ClinicalTrials.gov
NCT05286931	SpeeDx Ciprofloxacin gyrA Assay for N. Gonorrhoeae Gonococcal Infection	Not applicable	1,800		Neisseria Gonorrhoeae Infection	CIPROFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT00713999	Urogenital Schistosomiasis and Sexually Transmitted Infections in Madagascar	Not applicable	680		Sexually Transmitted Infections, Schistosoma Haematobium	PRAZIQUANTEL	Its record names the disease	ClinicalTrials.gov
NCT02210325	Efficacy and Safety Study of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea	Phase 3	264		Uncomplicated Urogenital Gonorrhea	AZITHROMYCIN, CEFTRIAXONE, SOLITHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT05216744	Comparison of Efficacy of Two Combination Regimens for the Neisseria Gonorrhoeae and Chlamydia Coinfection	Phase 2	125		Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection	CEFTRIAXONE, DOXYCYCLINE	Its record names the disease	ClinicalTrials.gov
NCT01591447	Safety and Efficacy Study of Single-Dose Oral CEM-101 in Patients With Uncomplicated Urogenital Gonorrhea	Phase 2	60		Uncomplicated Urogenital Gonorrhea	SOLITHROMYCIN	Its record names the disease	ClinicalTrials.gov
NCT01949363	The Pharmacokinetics of Extended Duration High-dose Cefixime for the Decreased Susceptibility of Neisseria Gonorrhoeae: A Phase I Pilot Study	Phase 1	25		Gonorrhoea	CEFIXIME	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials4

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Gepotidacin vs Ceftriaxone Plus Azithromycin: deaths from any cause	0 of 309	0 of 313	622	NCT04010539	Trial comparisons
Gepotidacin vs Ceftriaxone Plus Azithromycin: serious adverse events	1 of 309	0 of 313	622	NCT04010539	Trial comparisons
Delafloxacin vs Ceftriaxone: deaths from any cause	0 of 304	0 of 154	458	NCT02015637	Trial comparisons
Delafloxacin vs Ceftriaxone: serious adverse events	0 of 304	1 of 154	458	NCT02015637	Trial comparisons

Papers from its trials10

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
42841733	DERIVED	1	PubMed
40245902	DERIVED	1	PubMed
37751016	DERIVED	1	PubMed
36255258	DERIVED	1	PubMed
35810277	DERIVED	1	PubMed
31196813	DERIVED	1	PubMed
30985632	DERIVED	1	PubMed
30403954	DERIVED	1	PubMed
29624558	DERIVED	1	PubMed
26089222	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0004277

GET https://conductscience.org/api/diseases/v1/MONDO_0004277/drugs

API reference For AI assistants