Disease · MONDO_0005242

empyema

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. empyema. Diseases, record MONDO_0005242. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0005242

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: empyema; Open Targets
Open Targets ID: MONDO_0005242; Open Targets
MeSH: D004653; MeSH
NCI Thesaurus: C34572; NCI Thesaurus
Highest stage of its drugs: Approval, for 1 of its 10 drugs, from DailyMed; Open Targets

Drugs10

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
CLINDAMYCIN PHOSPHATE	CHEMBL3184512	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
ALTEPLASE	CHEMBL1201593	Enzyme	Phase 3	ClinicalTrials.gov	5	5	4	Drugs and targets
DORNASE ALFA	CHEMBL1201431	Enzyme	Phase 3	ClinicalTrials.gov	3	3	3	Drugs and targets
UROKINASE	CHEMBL1201420	Enzyme	Phase 3	ClinicalTrials.gov	2	2	2	Drugs and targets
CLINDAMYCIN	CHEMBL1753	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
HEPARIN	CHEMBL4650299	Oligosaccharide	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
LEVOFLOXACIN	CHEMBL5315124	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
MOXIFLOXACIN	CHEMBL32	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
SODIUM CHLORIDE	CHEMBL1200574	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets
TYLOXAPOL	CHEMBL1201548		Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets3

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
PLAT	Tissue-type plasminogen activator	1	Tissue-type plasminogen activator exogenous protein	Phase 3	https://conductscience.org/library/genes/5327	Drugs and targets
PLAU	Urokinase-type plasminogen activator	1	Urokinase-type plasminogen activator exogenous protein	Phase 3	https://conductscience.org/library/genes/5328	Drugs and targets
SERPINC1	Antithrombin-III	1	Antithrombin-III activator	Unknown	https://conductscience.org/library/genes/462	Drugs and targets

Trials9

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00468104	Efficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/Empyemas	Not applicable	100	2012-04-24	Pleural Effusion Associated With Pulmonary Infection, Bacterial Pleural Effusion Other Than Tuberculosis	ALTEPLASE	Its record names the disease	ClinicalTrials.gov
NCT06787885	Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema	Not applicable	80		Empyema, Pleural	CLINDAMYCIN, LEVOFLOXACIN, MOXIFLOXACIN	Its record names the disease	ClinicalTrials.gov
NCT07432373	Intrapleural Alteplase-Tyloxapol vs Intrapleural Alteplase-DNase in Pleural Infection		80		Pleural Infection	ALTEPLASE, DORNASE ALFA, TYLOXAPOL	Its record names the disease	ClinicalTrials.gov
NCT00103766	Alteplase for Treatment of Empyema and Complicated Parapneumonic Effusion	Not applicable	75		Empyema, Pleural Effusion	ALTEPLASE	Its record names the disease	ClinicalTrials.gov
NCT00144950	Urokinase Versus Primary Video-Assisted Thorascopic Surgery for Empyema	Phase 1	60		Empyema	UROKINASE	Its record names the disease	ClinicalTrials.gov
NCT02165891	Comparison of Intrapleural Urokinase and Video-Assisted Thorascopic Surgery in the Treatment of Parapneumonic Pleural Effusion in Children	Phase 3	40		Empyema, Pleural	UROKINASE	Its record names the disease	ClinicalTrials.gov
NCT05903417	Pleural Irrigation With Normal Saline Versus Intrapleural Fibrinolytic	Not applicable	40		Pleural Infection	ALTEPLASE, DORNASE ALFA	Its record names the disease	ClinicalTrials.gov
NCT06314620	Normal Saline Flushing With And Without Heparin Lock In Maintaining Small Bore Intercostal Chest Catheter (ICC) Patency	Not applicable	40		Pleural Effusion	HEPARIN, SODIUM CHLORIDE	Its record names the disease	ClinicalTrials.gov
NCT01862458	Empyema Treated With tPA & DNAse	Phase 3	0		Empyema	DORNASE ALFA	Its record names the disease	ClinicalTrials.gov

Comparisons in its trials1

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial
Alteplase vs Placebo: No Surgical Intervention	66 of 81	6 of 47	128	NCT00468104

Source Trial comparisons

Papers from its trials20

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
35581627	RESULT	1	PubMed
32367840	RESULT	1	PubMed
27333122	RESULT	1	PubMed
26449328	RESULT	1	PubMed
26254467	RESULT	1	PubMed
26075094	RESULT	1	PubMed
26022948	RESULT	1	PubMed
22398159	RESULT	1	PubMed
21830966	RESULT	1	PubMed
21633576	RESULT	1	PubMed

1 to 10 of 20

See all 20 papers from its trials

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0005242

GET https://conductscience.org/api/diseases/v1/MONDO_0005242/drugs

API reference For AI assistants