Disease · MONDO_0006042

meningeal tuberculosis

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. meningeal tuberculosis. Diseases, record MONDO_0006042. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0006042

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: meningeal tuberculosis; Open Targets
Open Targets ID: MONDO_0006042; Open Targets
Other names: Meningitis, Tuberculous, TB meningitis, TBM, tubercular meningitis, tuberculous meningitis; Open Targets
MeSH: D014390; MeSH
NCI Thesaurus: C84888; NCI Thesaurus
Orphanet: ORPHA:499004; Orphanet
Highest stage of its drugs: Approval, for 5 of its 22 drugs, from DailyMed; Open Targets

Drugs22

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
DEXAMETHASONE	CHEMBL384467	Small molecule	Approval	DailyMed	3	1	1	Drugs and targets
CORTISONE ACETATE	CHEMBL1650	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
DEXAMETHASONE SODIUM PHOSPHATE	CHEMBL2021430	Small molecule	Approval	DailyMed	2	0	0	Drugs and targets
PREDNISOLONE	CHEMBL131	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
PREDNISONE	CHEMBL635	Small molecule	Approval	DailyMed	1	0	0	Drugs and targets
RIFAMPIN	CHEMBL374478	Small molecule	Phase 2/3	ClinicalTrials.gov	7	7	7	Drugs and targets
CYCLOPHOSPHAMIDE	CHEMBL1200796	Small molecule	Phase 2/3	ClinicalTrials.gov	1	1	1	Drugs and targets
LINEZOLID	CHEMBL126	Small molecule	Phase 2	ClinicalTrials.gov	6	6	6	Drugs and targets
MOXIFLOXACIN	CHEMBL32	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
PYRAZINAMIDE	CHEMBL614	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets

1 to 10 of 22

See all 22 drugs

Targets4

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
NR3C1	Glucocorticoid receptor	5	Glucocorticoid receptor agonist	Approval	https://conductscience.org/library/genes/2908	Drugs and targets
PTGS1	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 2	https://conductscience.org/library/genes/5742	Drugs and targets
PTGS2	Cyclooxygenase	1	Cyclooxygenase inhibitor	Phase 2	https://conductscience.org/library/genes/5743	Drugs and targets
TNF	Tumor necrosis factor	1	TNF-alpha inhibitor	Phase 2	https://conductscience.org/library/genes/7124	Drugs and targets

Trials15

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT04021121	Adjunctive Linezolid for the Treatment of Tuberculous Meningitis	Phase 2	40	2024-10-01	Tuberculosis, Meningeal	LINEZOLID, RIFAMPIN	Its record names the disease	ClinicalTrials.gov
NCT03787940	Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis	Not applicable	676		Tuberculous Meningitis	ISONIAZID	Its record names the disease	ClinicalTrials.gov
NCT03092817	Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)	Phase 3	520		Tuberculosis, Tuberculous Meningitis, Drug-Induced Liver Injury, HIV, IRIS	DEXAMETHASONE	Its record names the disease	ClinicalTrials.gov
NCT07227779	BPaLMZ for TB Meningitis	Phase 2	312		Tuberculous Meningitis, HIV, Meningitis, TB - Tuberculosis	BEDAQUILINE, LINEZOLID, MOXIFLOXACIN, PRETOMANID, PYRAZINAMIDE, RIFAMPIN	Its record names the disease	ClinicalTrials.gov
NCT00433719	Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis	Not applicable	253		HIV Infections, Tuberculous Meningitis	EFAVIRENZ, LAMIVUDINE, ZIDOVUDINE	Its record names the disease	ClinicalTrials.gov
NCT03898635	Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis		150		Tuberculous Meningitis	LINEZOLID	Its record names the disease	ClinicalTrials.gov
NCT05590455	Tnf Inhibitors to Reduce Mortality in HIV-1 Infected PAtients With Tuberculosis meNIngitis	Phase 2	130		Tuberculous Meningitis, HIV I Infection	ADALIMUMAB	Its record names the disease	ClinicalTrials.gov
NCT07350174	Phase 2a Trial of Alpibectir Plus Ethionamide for Tuberculosis Meningitis	Phase 2	64		Tuberculosis Meningitis	ALPIBECTIR, ETHIONAMIDE	Open Targets' reading of its record	ClinicalTrials.gov
NCT01158755	Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study	Phase 2	60		Meningitis, Tuberculous, Pharmacokinetics, Pharmacodynamics, Tolerability	MOXIFLOXACIN, RIFAMPIN	Its record names the disease	ClinicalTrials.gov
NCT02169882	High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study	Phase 2/3	60		Tuberculosis, Meningeal	RIFAMPIN	Its record names the disease	ClinicalTrials.gov

1 to 10 of 15

See all 15 trials

Comparisons in its trials0

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

None in this release.

Papers from its trials10

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37819954	DERIVED	1	PubMed
37740554	DERIVED	1	PubMed
36482216	DERIVED	1	PubMed
35291004	DERIVED	1	PubMed
34286103	DERIVED	1	PubMed
33972248	DERIVED	1	PubMed
33283229	DERIVED	1	PubMed
30224533	DERIVED	1	PubMed
25703312	DERIVED	1	PubMed
23103177	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0006042

GET https://conductscience.org/api/diseases/v1/MONDO_0006042/drugs?page=2

API reference For AI assistants