Disease · MONDO_0008094

familial multiple nevi flammei

6 sourcesdiseases-2026-09-18-0.1.0

Cite this record

ConductScience Library. familial multiple nevi flammei. Diseases, record MONDO_0008094. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0008094

On this page

Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name: familial multiple nevi flammei; Open Targets
Open Targets ID: MONDO_0008094; Open Targets
Other names: Nevus flammeus, Salmon patch Nevus, capillary malformations, congenital, 1, somatic, mosaic, familial multiple port-wine stains, port wine Nevus, port wine birthmark, port wine stain, port wine stain of skin, port wine stain of the skin, port wine type hemangioma; Open Targets
Disease Ontology: DOID:0111529; Disease Ontology
NCI Thesaurus: C3840; NCI Thesaurus
Orphanet: ORPHA:624; Orphanet
Highest stage of its drugs: Phase 3, for 1 of its 7 drugs, from ClinicalTrials.gov; Open Targets

Drugs7

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Drug	ChEMBL ID	Type	Open Targets' stage	Stage reported by	Reports	Of them trials	Trials shown here	Source
TIMOLOL	CHEMBL499	Small molecule	Phase 3	ClinicalTrials.gov	1	1	1	Drugs and targets
SIROLIMUS	CHEMBL413	Small molecule	Phase 2	ClinicalTrials.gov	3	3	3	Drugs and targets
HEMATOPORPHYRIN	CHEMBL403729	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
IMIQUIMOD	CHEMBL1282	Small molecule	Phase 2	ClinicalTrials.gov	2	2	2	Drugs and targets
BOSENTAN	CHEMBL957	Small molecule	Phase 2	ClinicalTrials.gov	1	1	1	Drugs and targets
TALAPORFIN SODIUM	CHEMBL2107806	Small molecule	Phase 1	ClinicalTrials.gov	1	1	1	Drugs and targets
VERTEPORFIN	CHEMBL5314346	Small molecule	Unknown	ClinicalTrials.gov	1	1	1	Drugs and targets

Targets6

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

Target	Protein	Its drugs that act on it	Mechanisms	Highest stage of those drugs	Gene in Genes	Source
ADRB1	Beta-1 adrenergic receptor	1	Beta-1 adrenergic receptor antagonist	Phase 3	https://conductscience.org/library/genes/153	Drugs and targets
ADRB2	Beta-2 adrenergic receptor	1	Beta-2 adrenergic receptor antagonist	Phase 3	https://conductscience.org/library/genes/154	Drugs and targets
EDNRA	Endothelin receptor, ET-A/ET-B	1	Endothelin receptor, ET-A/ET-B antagonist	Phase 2	https://conductscience.org/library/genes/1909	Drugs and targets
EDNRB	Endothelin receptor, ET-A/ET-B	1	Endothelin receptor, ET-A/ET-B antagonist	Phase 2	https://conductscience.org/library/genes/1910	Drugs and targets
FKBP1A	Peptidyl-prolyl cis-trans isomerase FKBP1A	1	FK506-binding protein 1A inhibitor	Phase 2	https://conductscience.org/library/genes/2280	Drugs and targets
TLR7	Toll-like receptor 7	1	Toll-like receptor 7 agonist	Phase 2	https://conductscience.org/library/genes/51284	Drugs and targets

Trials11

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.

Trial	Title	Phase	Participants	Results first posted	Conditions	Drugs	Linked by	Source
NCT00585247	Combining Topical Imiquimod 5% Cream With a Pulsed Dye Laser to Treat Port Wine Stain Birthmarks	Not applicable	27	2018-04-04	Port Wine Stain	IMIQUIMOD	Its record names the disease	ClinicalTrials.gov
NCT00556946	Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains	Not applicable	17	2016-04-19	Port Wine Stains	VERTEPORFIN	Open Targets' reading of its record	ClinicalTrials.gov
NCT00979550	The Effects of Aldara as an Adjunct to Laser Treatment	Phase 2	7	2018-03-22	Port Wine Stains	IMIQUIMOD	Its record names the disease	ClinicalTrials.gov
NCT06875492	Retrospective Cohort Study on the Impact of PDL Treatment History on the Efficacy of HMME-PDT in Treating PWS Children		273		Port-Wine Stain	HEMATOPORPHYRIN	Its record names the disease	ClinicalTrials.gov
NCT05171894	A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT	Phase 2	84		Port-wine Birthmarks, Port-Wine Stain, Nevus Flammeus	HEMATOPORPHYRIN	Its record names the disease	ClinicalTrials.gov
NCT07436611	Rapamycin Dose-Ranging Efficacy Study in Port Wine Stains	Phase 2	30		Port Wine Stains	SIROLIMUS	Open Targets' reading of its record	ClinicalTrials.gov
NCT01272609	Treatment of Port Wine Stains in Children With Pulsed Dye Laser and Timolol Gel	Phase 3	25		Melanoma	TIMOLOL	Open Targets' reading of its record	ClinicalTrials.gov
NCT00800722	A Randomized Trial to Study Combined Pulsed Dye Laser and Rapamycin Treatment of Port Wine Stain Birthmarks.	Phase 1	21		Port Wine Stain	SIROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT02214706	Treatment of Port Wine Stains Using Pulsed Dye Laser, Erbium Yag Laser and Topical Sirolimus	Not applicable	17		Port-Wine Stain	SIROLIMUS	Its record names the disease	ClinicalTrials.gov
NCT01924273	Novel Treatment for Port Wine Stain Birthmarks	Phase 1	7		Port-Wine Stain	TALAPORFIN SODIUM	Its record names the disease	ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

Comparisons in its trials3

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Imiquimod vs Placebo: serious adverse events	0 of 14	0 of 13	27	NCT00585247	Trial comparisons
Aldara Cream vs Non-medicated Petroleum Cream: deaths from any cause	0 of 4	0 of 3	7	NCT00979550	Trial comparisons
Aldara Cream vs Non-medicated Petroleum Cream: serious adverse events	0 of 4	0 of 3	7	NCT00979550	Trial comparisons

Papers from its trials2

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
22244840	RESULT	1	PubMed
27320685	DERIVED	1	PubMed

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
Drug links and their checks, from Drugs and targets: 2026-09-18; Drugs and targets
ClinicalTrials.gov, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
PubMed, for the checks: 2026-11-06; PubMed
MeSH, for the checks: 2026-11-10; MeSH

Sources 6

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0008094

GET https://conductscience.org/api/diseases/v1/MONDO_0008094/drugs

API reference For AI assistants