Disease · MONDO_0020066
Ehlers-Danlos syndrome
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. Ehlers-Danlos syndrome. Diseases, record MONDO_0020066. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0020066
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Other names
Danlos Disease, Ehlers, Danlos disease, Disease, Ehlers Danlos, Dystrophia mesodermalis congenita, EDS, Ehler Danlos Syndrome, Ehlers Danlos Disease, Ehlers-Danlos syndromes, Fibrodysplasia elastica generalisata, Hereditary collagen dysplasia, Meekeren-Ehlers-Danlos syndrome, Syndrome, Ehlers-Danlos, danlos ehlers syndrome, elastic skin, skin elastic
- Open Targets
- Highest stage of its drugs
- Phase 3, for 2 of its 4 drugs, from ClinicalTrials.gov and TTD
- Open Targets
Drugs4
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| CELIPROLOL | CHEMBL27810 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| CELIPROLOL HYDROCHLORIDE | CHEMBL1742424 | Small molecule | Phase 3 | TTD | 1 | 0 | 0 | Drugs and targets |
| MECASERMIN | CHEMBL1201716 | Protein | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| NEPIDERMIN | CHEMBL2108314 | Protein | Unknown | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets6
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| ADRA2A | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 antagonist | Phase 3 | https://conductscience.org/library/genes/150 | Drugs and targets |
| ADRA2B | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 antagonist | Phase 3 | https://conductscience.org/library/genes/151 | Drugs and targets |
| ADRA2C | Adrenergic receptor alpha-2 | 1 | Adrenergic receptor alpha-2 antagonist | Phase 3 | https://conductscience.org/library/genes/152 | Drugs and targets |
| ADRB1 | Beta-1 adrenergic receptor | 1 | Beta-1 adrenergic receptor antagonist | Phase 3 | https://conductscience.org/library/genes/153 | Drugs and targets |
| ADRB2 | Beta-2 adrenergic receptor | 1 | Beta-2 adrenergic receptor partial agonist | Phase 3 | https://conductscience.org/library/genes/154 | Drugs and targets |
| IGF1R | Insulin-like growth factor 1 receptor | 1 | Insulin-like growth factor I receptor agonist | Unknown | https://conductscience.org/library/genes/3480 | Drugs and targets |
Trials3
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT05724589 | The Effectiveness of Epidermal Growth Factor Serum in Improve Facial Skin Hydration, Elasticity, Pigmentation, and Wrinkles. | Not applicable | 28 | 2025-07-31 | Aging | NEPIDERMIN | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT05432466 | Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome | Phase 3 | 150 | Vascular Ehlers-Danlos Syndrome | CELIPROLOL | Open Targets' reading of its record | ClinicalTrials.gov | |
| NCT01446783 | IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients | Not applicable | 15 | Ehlers-Danlos Syndrome, Classic | MECASERMIN | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials0
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
None in this release.
Papers from its trials0
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
None in this release.
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0020066
GET https://conductscience.org/api/diseases/v1/MONDO_0020066/drugs