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Disease · MONDO_0024332

perennial allergic rhinitis

6 sourcesdiseases-2026-09-18-0.1.0

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ConductScience Library. perennial allergic rhinitis. Diseases, record MONDO_0024332. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0024332

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Disease

Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.

Name
perennial allergic rhinitis
Open Targets
Open Targets ID
MONDO_0024332
Open Targets
Other names
Rhinitis, Allergic, Perennial, non-seasonal allergic rhinitis, nonseasonal allergic rhinitis
Open Targets
MeSH
D012221
MeSH
NCI Thesaurus
C92189
NCI Thesaurus
Highest stage of its drugs
Approval, for 12 of its 44 drugs, from DailyMed and EMA Human Drugs
Open Targets

Drugs44

The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

DrugChEMBL IDTypeOpen Targets' stageStage reported byReportsOf them trialsTrials shown hereSource
FLUTICASONE FUROATECHEMBL1676Small moleculeApprovalDailyMed and EMA Human Drugs161312Drugs and targets
CICLESONIDECHEMBL2040682Small moleculeApprovalDailyMed121010Drugs and targets
BECLOMETHASONE DIPROPIONATECHEMBL1200500Small moleculeApprovalDailyMed766Drugs and targets
AZELASTINE HYDROCHLORIDECHEMBL1200809Small moleculeApprovalDailyMed433Drugs and targets
DESLORATADINECHEMBL1172Small moleculeApprovalDailyMed and EMA Human Drugs1311Drugs and targets
LEVOCETIRIZINE DIHYDROCHLORIDECHEMBL1201190Small moleculeApprovalDailyMed411Drugs and targets
LORATADINECHEMBL998Small moleculeApprovalDailyMed311Drugs and targets
BUDESONIDECHEMBL1370Small moleculeApprovalDailyMed211Drugs and targets
MONTELUKAST SODIUMCHEMBL1200681Small moleculeApprovalDailyMed211Drugs and targets
CARBINOXAMINE MALEATECHEMBL1200974Small moleculeApprovalDailyMed100Drugs and targets

1 to 10 of 44

See all 44 drugs

Targets7

The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.

TargetProteinIts drugs that act on itMechanismsHighest stage of those drugsGene in GenesSource
HRH1Histamine H1 receptor20Histamine H1 receptor antagonist; Histamine H1 receptor inverse agonistApprovalhttps://conductscience.org/library/genes/3269Drugs and targets
NR3C1Glucocorticoid receptor17Glucocorticoid receptor agonistApprovalhttps://conductscience.org/library/genes/2908Drugs and targets
CYSLTR1Cysteinyl leukotriene receptor 12Cysteinyl leukotriene receptor 1 antagonistApprovalhttps://conductscience.org/library/genes/10800Drugs and targets
IL13Interleukin-131Interleukin-13 inhibitorPhase 3https://conductscience.org/library/genes/3596Drugs and targets
PTGDR2Prostaglandin D2 receptor 21G protein-coupled receptor 44 antagonistPhase 2/3https://conductscience.org/library/genes/11251Drugs and targets
SLC6A2Sodium-dependent noradrenaline transporter1Norepinephrine transporter releasing agentPhase 3https://conductscience.org/library/genes/6530Drugs and targets
TBXA2RThromboxane A2 receptor1Thromboxane A2 receptor antagonistPhase 2/3https://conductscience.org/library/genes/6915Drugs and targets

Trials62

Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs. 3 more are not shown, since the checks do not confirm them.

TrialTitlePhaseParticipantsResults first postedConditionsDrugsLinked bySource
NCT00092118The Clinical Effects of Montelukast in Patients With Perennial Allergic Rhinitis (0476-265)Phase 31,9922010-07-23Rhinitis, Allergic, PerennialMONTELUKASTIts record names the diseaseClinicalTrials.gov
NCT00974571Montelukast in Perennial Allergic Rhinitis - 2001-2002 Study (0476-246)Phase 31,3652010-06-07Perennial Allergic RhinitisMONTELUKASTIts record names the diseaseClinicalTrials.gov
NCT00953147A 6 Month Safety and Efficacy Study of Once Daily Ciclesonide Hydrofluoroalkane (HFA) in the Treatment of Perennial Allergic Rhinitis (PAR) in Subjects 12 Years and OlderPhase 31,1102012-06-07Allergic Rhinitis, Perennial Allergic RhinitisCICLESONIDEIts record names the diseaseClinicalTrials.gov
NCT00578331Safety Study of Olopatadine Nasal SprayPhase 38902010-02-03Perennial Allergic RhinitisOLOPATADINEIts record names the diseaseClinicalTrials.gov
NCT01451541A Safety and Efficacy Study of Ciclesonide Nasal Aerosol in Subjects 6-11 Years With Perennial Allergic Rhinitis (PAR).Phase 38482014-05-06Perennial Allergic Rhinitis, PARCICLESONIDEIts record names the diseaseClinicalTrials.gov
NCT01654536A 6 Month Safety Study Of Ciclesonide Nasal Aerosol (Zetonna®) And Ciclesonide Nasal Spray (Omnaris®) In Subjects 12 Years And Older With Perennial Allergic Rhinitis (PAR)Phase 47372014-07-24Perennial Allergic RhinitisCICLESONIDEIts record names the diseaseClinicalTrials.gov
NCT00720382A Study to Evaluate the Safety and Tolerability of a Nasal Spray to Treat Perennial Allergic RhinitisPhase 37032010-01-15Perennial Allergic RhinitisAZELASTINE HYDROCHLORIDE, MOMETASONE FUROATEIts record names the diseaseClinicalTrials.gov
NCT02709538Long Term Safety and Efficacy of Fixed Dose Combination GSP 301 Nasal Spray (NS) in the Treatment of Perennial Allergic Rhinitis (PAR)Phase 36012018-09-13Perennial Allergic RhinitisMOMETASONE FUROATE, OLOPATADINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov
NCT00704769Response of Desloratadine Syrup in the Relief of Symptoms Associated With Perennial Allergic Rhinitis in Pediatric Patients (Study P04299)5912009-08-11RhinitisDESLORATADINEIts record names the diseaseClinicalTrials.gov
NCT00712920A Study to Evaluate the Safety and Effectiveness of a Nasal Spray to Treat Perennial AllergiesPhase 35812010-01-15Perennial Allergic RhinitisAZELASTINE HYDROCHLORIDEIts record names the diseaseClinicalTrials.gov

1 to 10 of 62

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Comparisons in its trials19

Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.

ComparisonGroup 1, with the outcomeGroup 2, with the outcomeParticipantsTrialSource
Montelukast 10 mg vs Placebo: serious adverse events4 of 1,0021 of 9901,992NCT00092118Trial comparisons
Olopatadine 0.6% Nasal Spray vs Placebo Nasal Spray: serious adverse events15 of 44515 of 445890NCT00578331Trial comparisons
Ciclesonide Nasal Aerosol vs Ciclesonide Nasal Spray: Number of Subjects With Increase ≥ 7 mm Hg From Baseline in Intraocular Pressure, or a Change to > 21 mm Hg, in Either Eye9 of 3676 of 370737NCT01654536Trial comparisons
Ciclesonide Nasal Aerosol vs Ciclesonide Nasal Spray: Number of Subjects With Development of or Worsening in Lens Opacities.51 of 36753 of 370737NCT01654536Trial comparisons
Ciclesonide Nasal Aerosol vs Ciclesonide Nasal Spray: Number of Subjects With Change From Baseline in Best Corrected Visual Acuity.1 of 3672 of 370737NCT01654536Trial comparisons
Ciclesonide Nasal Aerosol vs Ciclesonide Nasal Spray: serious adverse events4 of 3675 of 370737NCT01654536Trial comparisons
Astepro 0.15% vs Nasonex®: serious adverse events4 of 4664 of 237703NCT00720382Trial comparisons
FF 110 mcg QD vs Placebo: serious adverse events12 of 3677 of 181548NCT00682643Trial comparisons
BDP Nasal Aerosol 80 mcg/Day vs Placebo Nasal Aerosol: serious adverse events0 of 3620 of 185547NCT01783548Trial comparisons
BDP HFA 320 µg/Day vs Placebo: serious adverse events8 of 4153 of 111526NCT00988247Trial comparisons

1 to 10 of 19

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Papers from its trials25

The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMIDListed asTrials listing itSource
30525743RESULT1PubMed
27785374RESULT1PubMed
26364765RESULT2PubMed
22737708RESULT2PubMed
22370530RESULT1PubMed
22092947RESULT1PubMed
22077106RESULT1PubMed
18164990RESULT1PubMed
17651373RESULT1PubMed
17619558RESULT1PubMed

1 to 10 of 25

See all 25 papers from its trials

Data dates

The date of each source this release read.

Open Targets
2026-09-18
Open Targets
Drug links and their checks, from Drugs and targets
2026-09-18
Drugs and targets
ClinicalTrials.gov, from Trials
2026-11-12
Trials
Comparisons, from Trial comparisons
2026-03-23
Trial comparisons
PubMed, for the checks
2026-11-06
PubMed
MeSH, for the checks
2026-11-10
MeSH

Sources 6

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • NLM's MeSHNLM's terms
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • NLM's MeSHNLM's
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this disease from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/diseases/v1/MONDO_0024332

GET https://conductscience.org/api/diseases/v1/MONDO_0024332/drugs?page=2

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