Disease · MONDO_0100620
developmental and epileptic encephalopathy
6 sourcesdiseases-2026-09-18-0.1.0
Cite this record
ConductScience Library. developmental and epileptic encephalopathy. Diseases, record MONDO_0100620. Release diseases-2026-09-18-0.1.0, 18 Sept 2026. https://conductscience.org/library/diseases/MONDO_0100620
On this page
Disease
Names and IDs as Open Targets gives them. Its IDs in MeSH, Orphanet, the Disease Ontology and the NCI Thesaurus are those Open Targets states for it.
- Name
- developmental and epileptic encephalopathy
- Open Targets ID
- MONDO_0100620
- Other names
- DEE
- Highest stage of its drugs
- Phase 3, for 2 of its 4 drugs, from ClinicalTrials.gov
Source Open Targets
Drugs4
The drugs Open Targets' clinical reports study for the disease, the highest stage first, then the most trial reports. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Drug | ChEMBL ID | Type | Open Targets' stage | Stage reported by | Reports | Of them trials | Trials shown here | Source |
|---|---|---|---|---|---|---|---|---|
| ELSUNERSEN | CHEMBL6068116 | Oligonucleotide | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| EZOGABINE | CHEMBL41355 | Small molecule | Phase 3 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
| SOTICLESTAT | CHEMBL4298172 | Small molecule | Phase 2 | ClinicalTrials.gov | 2 | 2 | 2 | Drugs and targets |
| BEXICASERIN | CHEMBL5314507 | Small molecule | Phase 2 | ClinicalTrials.gov | 1 | 1 | 1 | Drugs and targets |
Targets6
The targets ChEMBL's mechanism records give for the disease's drugs, through Open Targets, the most drugs first. A mechanism record says what a drug acts on, not that the target causes the disease.
| Target | Protein | Its drugs that act on it | Mechanisms | Highest stage of those drugs | Gene in Genes | Source |
|---|---|---|---|---|---|---|
| CYP46A1 | Cholesterol 24-hydroxylase | 1 | Cholesterol 24-hydroxylase inhibitor | Phase 2 | https://conductscience.org/library/genes/10858 | Drugs and targets |
| KCNQ1 | KCNQ (Kv7) potassium channel | 1 | KCNQ (Kv7) potassium channel opener | Phase 3 | https://conductscience.org/library/genes/3784 | Drugs and targets |
| KCNQ2 | KCNQ (Kv7) potassium channel | 1 | KCNQ (Kv7) potassium channel opener | Phase 3 | https://conductscience.org/library/genes/3785 | Drugs and targets |
| KCNQ3 | KCNQ (Kv7) potassium channel | 1 | KCNQ (Kv7) potassium channel opener | Phase 3 | https://conductscience.org/library/genes/3786 | Drugs and targets |
| KCNQ4 | KCNQ (Kv7) potassium channel | 1 | KCNQ (Kv7) potassium channel opener | Phase 3 | https://conductscience.org/library/genes/9132 | Drugs and targets |
| KCNQ5 | KCNQ (Kv7) potassium channel | 1 | KCNQ (Kv7) potassium channel opener | Phase 3 | https://conductscience.org/library/genes/56479 | Drugs and targets |
Trials5
Trials an Open Targets clinical report links to the disease, posted results first, then the largest. A trial is shown when the release's checks confirm its link to the disease and Drugs and targets shows its link to one of the disease's drugs.
| Trial | Title | Phase | Participants | Results first posted | Conditions | Drugs | Linked by | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03635073 | A Study of Soticlestat in Adults and Children With Rare Epilepsies | Phase 2 | 156 | 2026-03-19 | Epilepsy, Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | SOTICLESTAT | Its record names the disease | ClinicalTrials.gov |
| NCT03166215 | Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies | Phase 1/2 | 18 | 2020-01-10 | Developmental and/or Epileptic Encephalopathies | SOTICLESTAT | Open Targets' reading of its record | ClinicalTrials.gov |
| NCT04639310 | XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy | Phase 3 | 8 | 2024-08-23 | Epilepsy, Epilepsy in Children, Epilepsy; Seizure, Disease, Brain Diseases, Central Nervous System Diseases, Nervous System Diseases, Epileptic Syndromes | EZOGABINE | Its record names the disease | ClinicalTrials.gov |
| NCT05626634 | Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy | Phase 2 | 41 | Developmental and Epileptic Encephalopathy, Dravet Syndrome, Lennox-Gastaut Syndrome | BEXICASERIN | Its record names the disease | ClinicalTrials.gov | |
| NCT07019922 | A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety | Phase 3 | 40 | Epileptic Encephalopathy, SCN2A Encephalopathy | ELSUNERSEN | Its record names the disease | ClinicalTrials.gov |
Comparisons in its trials3
Comparisons Trial comparisons calculated in the trials shown here, most participants first. A comparison in one of these trials does not always compare a treatment for the disease, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| XEN496 vs Placebo: Percentage of Subjects With ≥50 Percent Reduction in Monthly (28 Day) Seizure Frequency | 2 of 5 | 0 of 3 | 8 | NCT04639310 | Trial comparisons |
| XEN496 vs Placebo: deaths from any cause | 0 of 5 | 0 of 3 | 8 | NCT04639310 | Trial comparisons |
| XEN496 vs Placebo: serious adverse events | 1 of 5 | 1 of 3 | 8 | NCT04639310 | Trial comparisons |
Papers from its trials1
The papers the trials shown here list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it |
|---|---|---|
| 33940389 | DERIVED | 1 |
Source PubMed
Data dates
The date of each source this release read.
Sources 6
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this disease from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/diseases/v1/MONDO_0100620
GET https://conductscience.org/api/diseases/v1/MONDO_0100620/drugs