Drug · CHEMBL134

CLONIDINE

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. CLONIDINE. Drugs and targets, record CHEMBL134. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL134

On this page

Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: CLONIDINE; ChEMBL
ChEMBL ID: CHEMBL134; ChEMBL
Type: Small molecule; ChEMBL
Brand names: Catapres-tts-1, Catapres-tts-2, Catapres-tts-3, Nexiclon xr; ChEMBL
Other names: Catarpres-tts, Clonidina, Clonidine extended release, Clorpres, Combipres, ST-155-BS, ST-155BS; ChEMBL
Other form: CLONIDINE HYDROCHLORIDE, CHEMBL1705; Drugs and targets
DrugBank: DB00575; DrugBank
InChIKey: GJSURZIOUXUGAL-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 5 of its 53 diseases, from ATC, DailyMed and TTD; Open Targets

Targets3

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
ADRA2A	Adrenergic receptor alpha-2	Adrenergic receptor alpha-2 agonist	AGONIST	https://conductscience.org/library/genes/150
ADRA2B	Adrenergic receptor alpha-2	Adrenergic receptor alpha-2 agonist	AGONIST	https://conductscience.org/library/genes/151
ADRA2C	Adrenergic receptor alpha-2	Adrenergic receptor alpha-2 agonist	AGONIST	https://conductscience.org/library/genes/152

Source ChEMBL

Diseases53

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
Pain	Phase 3	ClinicalTrials.gov	15	15	https://conductscience.org/library/drugs?q=HP_0012531
hypertensive disorder	Approval	ATC, DailyMed and TTD	20	6	https://conductscience.org/library/drugs?q=MONDO_0005044
neonatal abstinence syndrome	Phase 3	ClinicalTrials.gov	5	5	https://conductscience.org/library/drugs?q=MONDO_0005566
Chronic pain	Phase 3	ClinicalTrials.gov	4	4	https://conductscience.org/library/drugs?q=HP_0012532
delirium	Phase 3	ClinicalTrials.gov	4	4	https://conductscience.org/library/drugs?q=MONDO_0045057
neuropathic pain	Approval	DailyMed	4	3	https://conductscience.org/library/drugs?q=EFO_0005762
anxiety	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=MONDO_0011918
attention deficit-hyperactivity disorder	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=MONDO_0007743
sedation	Phase 3	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=EFO_0009868
fecal incontinence	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=EFO_0009523

1 to 10 of 53Source Open Targets

See all 53 diseases

Trials234

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs. 2 more that Open Targets linked to it are not shown, since the release's checks do not confirm them.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT01082874	PeriOperative ISchemic Evaluation-2 Trial	Phase 3	10,010	2016-08-25	clonidine	Its name	ClinicalTrials.gov
NCT00535925	Nephropathy In Type 2 Diabetes and Cardio-renal Events	Phase 4	850	2020-05-11	clonidine	Its name	ClinicalTrials.gov
NCT02361476	Does Intraoperative Clonidine Reduce Post Operative Agitation in Children?	Phase 4	379	2019-02-11	clonidine	Its name	ClinicalTrials.gov
NCT02371759	Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2	Phase 3	256	2017-05-03	clonidine	Its name	ClinicalTrials.gov
NCT02543801	A Clinical Trial of Two Periarticular Multimodal Drug Injections in Total Hip and Knee Arthroplasty	Phase 4	239	2019-10-18	clonidine	Its name	ClinicalTrials.gov
NCT01385748	Efficacy and Safety Study of Clonidine Lauriad® to Treat Oral Mucositis	Phase 2	183	2017-08-09	clonidine	Its name	ClinicalTrials.gov
NCT00695565	Efficacy and Safety Study of ARC-4558 for Management of Pain Associated With Painful Diabetic Neuropathy	Phase 2	180	2016-11-08	clonidine	Its name	ClinicalTrials.gov
NCT01042093	Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)		160	2013-11-08	clonidine	Its name	ClinicalTrials.gov
NCT03117140	Analgesia Duration of Dexamethasone, Buprenorphine, or Clonidine With Ropivacaine for Interscalene Nerve Block	Phase 4	160	2018-07-03	clonidine	Its name	ClinicalTrials.gov
NCT01813149	Mechanism and Treatment of Sympathetically Maintained Pain		128	2021-01-13	clonidine	Its name	ClinicalTrials.gov

1 to 10 of 234

See all 234 trials

Comparisons in its trials76

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Conventional Therapy vs Intensified Therapy: Number of Participants With Overall Fatal and Non-fatal, Major Adverse Cardiovascular Events (MACEs)	146 of 188	116 of 207	395	NCT00535925	Trial comparisons
Conventional Therapy vs Intensified Therapy: deaths from any cause	103 of 188	86 of 207	395	NCT00535925	Trial comparisons
Conventional Therapy vs Intensified Therapy: serious adverse events	88 of 188	69 of 207	395	NCT00535925	Trial comparisons
Intervention vs Placebo: deaths from any cause	0 of 191	0 of 188	379	NCT02361476	Trial comparisons
Intervention vs Placebo: serious adverse events	2 of 191	2 of 188	379	NCT02361476	Trial comparisons
Multifactorial Intensified Therapy vs Standard of Care (SoC) Therapy: Number of Participants Who Achieved of BP, HbA1c and Total, HDL and LDL Cholesterol Goals at the End of Intervention Phase	191 of 199	150 of 169	368	NCT00535925	Trial comparisons
Clonidine Topical Gel (ARC-4558) vs Placebo Gel: serious adverse events	3 of 90	3 of 90	180	NCT00695565	Trial comparisons
Intervention (Protocolized Clonidine Initiation) vs Usual Care (Without Protocolized Clonidine Initiation): deaths from any cause	0 of 32	0 of 96	128	NCT05575219	Trial comparisons
Intervention (Protocolized Clonidine Initiation) vs Usual Care (Without Protocolized Clonidine Initiation): serious adverse events	0 of 32	0 of 96	128	NCT05575219	Trial comparisons
Intervention (Protocolized Clonidine Initiation) vs Usual Care (Without Protocolized Clonidine Initiation): Number of Participants With Withdrawal	10 of 30	33 of 91	121	NCT05575219	Trial comparisons

1 to 10 of 76

See all 76 comparisons in its trials

Papers from its trials158

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
37338615	RESULT	1	PubMed
35112665	RESULT	1	PubMed
32769505	RESULT	1	PubMed
31366330	RESULT	1	PubMed
30802933	RESULT	1	PubMed
27819386	RESULT	1	PubMed
27819381	RESULT	1	PubMed
27298661	RESULT	1	PubMed
26811272	RESULT	1	PubMed
26447431	RESULT	1	PubMed

1 to 10 of 158

See all 158 papers from its trials

Tests in its trials8

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

Test	Trials naming it as an outcome	As a primary outcome	Source
Digit Span Test	2	1	ConductCognition
Trail Making Test A	2	1	ConductCognition
Trail Making Test B	2	1	ConductCognition
Finger Tapping Task	1	1	ConductCognition
2-Back Task	1	1	ConductCognition
Stroop Color-Word Test	1	0	ConductCognition
Verbal Fluency	1	0	ConductCognition
Verbal Learning	1	1	ConductCognition

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL134

GET https://conductscience.org/api/drugs/v1/CHEMBL134/diseases?page=2

API reference For AI assistants