Drug · CHEMBL485
CODEINE
7 sourcespipelines-2026-09-18-0.3.1
Cite this record
ConductScience Library. CODEINE. Drugs and targets, record CHEMBL485. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL485
On this page
Drug
Names and IDs as ChEMBL gives them, through Open Targets.
- Other names
- Codeine monohydrate, Codeinum, Codeinum monohydricum, Dea no. 9050, IDS-NC-005(SECT.-2)
- ChEMBL
Targets3
The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.
| Target | Protein | Mechanism | Action | Gene in Genes |
|---|---|---|---|---|
| OPRD1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta agonist | AGONIST | https://conductscience.org/library/genes/4985 |
| OPRK1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta agonist | AGONIST | https://conductscience.org/library/genes/4986 |
| OPRM1 | Opioid receptors; mu/kappa/delta | Opioid receptors; mu/kappa/delta agonist | AGONIST | https://conductscience.org/library/genes/4988 |
Source ChEMBL
Diseases6
The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.
| Disease | Open Targets' stage | Stage reported by | Reports | Of them trials | Its drugs |
|---|---|---|---|---|---|
| Pain | Approval | ATC and TTD | 14 | 11 | https://conductscience.org/library/drugs?q=HP_0012531 |
| Cough | Approval | ATC | 3 | 1 | https://conductscience.org/library/drugs?q=HP_0012735 |
| Headache | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0002315 |
| Low back pain | Unknown | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=HP_0003419 |
| constipation disorder | Phase 1 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=MONDO_0002203 |
| toothache | Phase 3 | ClinicalTrials.gov | 1 | 1 | https://conductscience.org/library/drugs?q=EFO_0010072 |
Source Open Targets
Trials48
Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.
| Trial | Title | Phase | Participants | Results first posted | Named as | Linked by | Source |
|---|---|---|---|---|---|---|---|
| NCT01402375 | Comparing the Efficacy of Oral Opioids for Outpatient Acute Pain Management After ED Discharge Discharge | Phase 3 | 720 | 2018-05-01 | codeine | Its name | ClinicalTrials.gov |
| NCT01229449 | Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study | Phase 3 | 678 | 2018-09-17 | codeine | Its name | ClinicalTrials.gov |
| NCT03173456 | Comparing Five Oral Analgesics for Treatment of Acute Pain in the Emergency Department (ED) | Phase 2 | 600 | 2022-02-01 | codeine | Its name | ClinicalTrials.gov |
| NCT00694369 | A Study to Asses the Effect of MK0663 in the Treatment of Patients With Postoperative Dental Pain (0663-092) | Phase 3 | 588 | 2010-01-29 | codeine | Its name | ClinicalTrials.gov |
| NCT02455518 | Comparative Efficacy of 4 Oral Analgesics | Phase 4 | 416 | 2018-02-13 | codeine | Its name | ClinicalTrials.gov |
| NCT00784810 | A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis | Phase 4 | 247 | 2011-11-02 | codeine | Its name | ClinicalTrials.gov |
| NCT04399122 | Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone | Phase 4 | 200 | 2021-10-05 | codeine | Its name | ClinicalTrials.gov |
| NCT02647788 | Acetaminophen/Codeine vs Acetaminophen/Ibuprofen for Pain Control and Patient Satisfaction After Hand Surgery | Phase 4 | 144 | 2019-02-18 | codeine | Its name | ClinicalTrials.gov |
| NCT01267136 | A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy | Phase 4 | 84 | 2014-04-17 | codeine | Its name | ClinicalTrials.gov |
| NCT02295280 | A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective. | 70 | 2018-04-02 | codeine | Its name | ClinicalTrials.gov |
1 to 10 of 48
See all 48 trialsComparisons in its trials11
Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.
| Comparison | Group 1, with the outcome | Group 2, with the outcome | Participants | Trial | Source |
|---|---|---|---|---|---|
| Oxycodone/Naloxone Tablets (OXN) vs Codeine/Paracetamol Tablets: serious adverse events | 3 of 124 | 4 of 123 | 247 | NCT00784810 | Trial comparisons |
| Acetaminophen With Codeine vs Acetaminophen With Oxycodone: deaths from any cause | 0 of 97 | 0 of 100 | 197 | NCT04399122 | Trial comparisons |
| Acetaminophen With Codeine vs Acetaminophen With Oxycodone: serious adverse events | 0 of 97 | 0 of 100 | 197 | NCT04399122 | Trial comparisons |
| Acetaminophen/Ibuprofen vs Acetaminophen/Codeine: deaths from any cause | 0 of 70 | 0 of 70 | 140 | NCT02647788 | Trial comparisons |
| Acetaminophen/Ibuprofen vs Acetaminophen/Codeine: serious adverse events | 0 of 70 | 0 of 70 | 140 | NCT02647788 | Trial comparisons |
| Capital® With Codeine Suspension vs Tramadol Suspension: serious adverse events | 1 of 42 | 1 of 42 | 84 | NCT01267136 | Trial comparisons |
| Metoclopramide & Diphenhydramine vs Codeine: deaths from any cause | 0 of 35 | 0 of 35 | 70 | NCT02295280 | Trial comparisons |
| Metoclopramide & Diphenhydramine vs Codeine: serious adverse events | 0 of 35 | 0 of 35 | 70 | NCT02295280 | Trial comparisons |
| Cannabidiol vs Tylenol T3: deaths from any cause | 0 of 35 | 0 of 35 | 70 | NCT05477875 | Trial comparisons |
| Cannabidiol vs Tylenol T3: serious adverse events | 0 of 35 | 0 of 35 | 70 | NCT05477875 | Trial comparisons |
1 to 10 of 11
See all 11 comparisons in its trialsPapers from its trials15
The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.
| PMID | Listed as | Trials listing it | Source |
|---|---|---|---|
| 20839388 | RESULT | 1 | PubMed |
| 19937046 | RESULT | 1 | PubMed |
| 42524865 | DERIVED | 1 | PubMed |
| 37349498 | DERIVED | 1 | PubMed |
| 34922726 | DERIVED | 1 | PubMed |
| 34655316 | DERIVED | 1 | PubMed |
| 33470341 | DERIVED | 1 | PubMed |
| 33358232 | DERIVED | 1 | PubMed |
| 32973880 | DERIVED | 1 | PubMed |
| 32797734 | DERIVED | 1 | PubMed |
1 to 10 of 15
See all 15 papers from its trialsTests in its trials2
The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.
| Test | Trials naming it as an outcome | As a primary outcome | Source |
|---|---|---|---|
| Trail Making Test A | 1 | 0 | ConductCognition |
| Trail Making Test B | 1 | 0 | ConductCognition |
Data dates
The date of each source this release read.
Sources 7
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ConductCognition's list of its testsOur own data
- ClinicalTrials.govNo license stated
- NLM's MeSHNLM's terms
- Open TargetsCC0 1.0
- PubMedNLM's terms
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
- ClinicalTrials.govnone stated
- NLM's MeSHNLM's
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this drug from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/drugs/v1/CHEMBL485
GET https://conductscience.org/api/drugs/v1/CHEMBL485/trials?page=2