Drug · CHEMBL768

ESMOLOL

7 sourcespipelines-2026-09-18-0.3.1

Cite this record

ConductScience Library. ESMOLOL. Drugs and targets, record CHEMBL768. Release pipelines-2026-09-18-0.3.1, 18 Sept 2026. https://conductscience.org/library/drugs/CHEMBL768

On this page

Drug

Names and IDs as ChEMBL gives them, through Open Targets.

Name: ESMOLOL; ChEMBL
ChEMBL ID: CHEMBL768; ChEMBL
Type: Small molecule; ChEMBL
Other names: ASL-8052-001; ChEMBL
Other form: ESMOLOL HYDROCHLORIDE, CHEMBL1201115; Drugs and targets
DrugBank: DB00187; DrugBank
InChIKey: AQNDDEOPVVGCPG-UHFFFAOYSA-N; ChEMBL
Open Targets' highest stage: Approval, for 1 of its 25 diseases, from ATC; Open Targets

Targets2

The targets ChEMBL's mechanism records give for the drug, through Open Targets. A mechanism record says what the drug acts on, not how strongly.

Target	Protein	Mechanism	Action	Gene in Genes
ADRB1	Beta-1 adrenergic receptor	Beta-1 adrenergic receptor antagonist	ANTAGONIST	https://conductscience.org/library/genes/153
ADRB2	Beta-2 adrenergic receptor	Beta-2 adrenergic receptor antagonist	ANTAGONIST	https://conductscience.org/library/genes/154

Source ChEMBL

Diseases25

The diseases Open Targets' clinical reports study the drug for, the most trial reports first. The stage is Open Targets', the highest any of its sources reports for the pair, and each row names the sources that report it.

Disease	Open Targets' stage	Stage reported by	Reports	Of them trials	Its drugs
septic shock	Phase 3	ClinicalTrials.gov	13	13	https://conductscience.org/library/drugs?q=EFO_0006834
Tachycardia	Phase 3	ClinicalTrials.gov	4	4	https://conductscience.org/library/drugs?q=HP_0001649
Sepsis	Phase 2	ClinicalTrials.gov	3	3	https://conductscience.org/library/drugs?q=HP_0100806
Pain	Phase 2	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=HP_0012531
atrial fibrillation	Phase 2	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0004981
hypertensive disorder	Phase 3	ClinicalTrials.gov	2	2	https://conductscience.org/library/drugs?q=MONDO_0005044
Increased blood pressure	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=HP_0032263
acute myocardial infarction	Phase 2	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0004781
acute respiratory distress syndrome	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0006502
brain edema	Phase 3	ClinicalTrials.gov	1	1	https://conductscience.org/library/drugs?q=MONDO_0006684

1 to 10 of 25Source Open Targets

See all 25 diseases

Trials91

Trials whose record names the drug by a name ChEMBL states, posted results first, then the largest. Open Targets read each trial's text to find its drugs.

Trial	Title	Phase	Participants	Results first posted	Named as	Linked by	Source
NCT01208402	Esmolol for Treatment of Perioperative Tachycardia	Phase 3	76	2014-11-19	esmolol	Its name	ClinicalTrials.gov
NCT01114971	Labetalol and Esmolol: Vital Signs and Post Operative Pain Management	Phase 4	75	2020-02-20	esmolol	Its name	ClinicalTrials.gov
NCT01212874	Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery		70	2016-08-17	esmolol	Its name	ClinicalTrials.gov
NCT01782898	The Effect of Intraoperative Esmolol to Improve Postoperative Quality of Recovery and Pain After Ambulatory Surgery		70	2016-04-04	esmolol	Its name	ClinicalTrials.gov
NCT00756236	A Comparison of the Effects of Intraoperative Administration of Metoprolol or Esmolol on General Anesthetic Requirement		60	2017-06-28	esmolol	Its name	ClinicalTrials.gov
NCT01951950	Nicardipine vs Esmolol Craniotomy Emergence	Phase 1	40	2014-08-29	esmolol	Its name	ClinicalTrials.gov
NCT02369900	Esmolol to Treat the Hemodynamic Effects of Septic Shock	Phase 2	40	2021-06-28	esmolol	Its name	ClinicalTrials.gov
NCT01179113	Esmolol Infusion During Laminectomy: Effect on Quality of Recovery	Phase 4	33	2016-08-30	esmolol	Its name	ClinicalTrials.gov
NCT04356352	Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain	Phase 2/3	33	2024-09-19	esmolol	Its name	ClinicalTrials.gov
NCT01114997	Effect of Lidocaine and Esmolol to Improve the Quality of Recovery	Phase 4	32	2016-06-23	esmolol	Its name	ClinicalTrials.gov

1 to 10 of 91

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Comparisons in its trials13

Comparisons Trial comparisons calculated in the trials whose record names the drug, most participants first. A comparison in one of its trials does not always compare the drug, so read the two groups.

Comparison	Group 1, with the outcome	Group 2, with the outcome	Participants	Trial	Source
Esmolol vs Nitroglycerin: serious adverse events	0 of 35	0 of 35	70	NCT01212874	Trial comparisons
Long-Acting Beta Blocker vs Esmolol: serious adverse events	2 of 31	2 of 28	59	NCT01208402	Trial comparisons
Esmolol vs .9 Normal Saline: serious adverse events	0 of 29	0 of 29	58	NCT01782898	Trial comparisons
Esmolol vs Saline: deaths from any cause	0 of 27	0 of 27	54	NCT04181606	Trial comparisons
Esmolol vs Saline: serious adverse events	0 of 27	0 of 27	54	NCT04181606	Trial comparisons
Nicardipine vs Esmolol: serious adverse events	0 of 26	0 of 26	52	NCT01951950	Trial comparisons
Nicardipine vs Esmolol: Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg	1 of 20	11 of 20	40	NCT01951950	Trial comparisons
Esmolol Infusion vs Standard Care, Saline: deaths from any cause	6 of 18	8 of 22	40	NCT02369900	Trial comparisons
Esmolol Infusion vs Standard Care, Saline: serious adverse events	4 of 18	0 of 22	40	NCT02369900	Trial comparisons
Esmolol vs Placebo: Postoperative Nausea and Vomiting	0 of 16	2 of 17	33	NCT01179113	Trial comparisons

1 to 10 of 13

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Papers from its trials59

The papers the trials whose record names the drug list on ClinicalTrials.gov as their results (RESULT) or as drawn from them (DERIVED), results first, newest first.

PMID	Listed as	Trials listing it	Source
40009025	RESULT	1	PubMed
38240494	RESULT	1	PubMed
31045633	RESULT	1	PubMed
30424939	RESULT	1	PubMed
25886340	RESULT	1	PubMed
19302635	RESULT	1	PubMed
18396107	RESULT	1	PubMed
17959952	RESULT	1	PubMed
16914460	RESULT	1	PubMed
15716709	RESULT	1	PubMed

1 to 10 of 59

See all 59 papers from its trials

Tests in its trials0

The tests ConductCognition runs that the trials whose record names the drug name in their registered outcomes, as ScienceGraph matched them. ConductCognition's list names the tests it runs, not every test a trial used.

None in this release.

Data dates

The date of each source this release read.

Open Targets: 2026-09-18; Open Targets
ClinicalTrials.gov: 2026-11-05; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
Papers the trials list, from Trials: 2026-11-12; Trials
Comparisons, from Trial comparisons: 2026-03-23; Trial comparisons
Tests named in the trials, as ScienceGraph matched them: 2026-11-12; ConductCognition

Sources 7

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ChEMBL, through Open TargetsCC BY-SA 3.0
ConductCognition's list of its testsOur own data
ClinicalTrials.govNo license stated
NLM's MeSHNLM's terms
Open TargetsCC0 1.0
PubMedNLM's terms

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
ConductCognition's list of its testsOur own data: ConductCognition's list of its tests, https://conductcognition.com
ClinicalTrials.govnone stated
NLM's MeSHNLM's
Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
PubMedNLM's terms

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this drug from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/drugs/v1/CHEMBL768

GET https://conductscience.org/api/drugs/v1/CHEMBL768/diseases?page=2

API reference For AI assistants