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Paper · 15535842

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.

Dontu G and 5 others. Breast Cancer Res, 2004. Cited by 581 papers, by iCite.

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ConductScience Library. Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Papers, record 15535842. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/15535842

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells.
PubMed
Journal
Breast Cancer Res
PubMed
Year
2004
PubMed
Publication types
Journal Article, Research Support, U.S. Gov't, P.H.S.
PubMed
Citations, by iCite
581
iCite
Relative citation ratio, by iCite
10.7
iCite
Revised in PubMed
2022-04-08
PubMed

Authors6

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Dontu GGabriela
2Jackson KWKyle W
3McNicholas EErin
4Kawamura MJMari J
5Abdallah WMWissam M
6Wicha MSMax S

Source PubMed

Topics15

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Mammary Glands, HumanMajor topic
Proto-Oncogene ProteinsMajor topic
Receptors, Cell SurfaceMajor topic
Stem CellsMajor topic
Transcription FactorsMajor topic
Cell Differentiation
Cells, Cultured
Epithelial Cells
Female
Humans
Proto-Oncogene Mas
Receptor, Notch1
Receptor, Notch4
Receptors, Notch
Signal Transduction

Source PubMed

Grants4

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
R01 CA101860NCI NIH HHSUnited StatesR01CA101860PubMed and NIHNIH RePORTER
5 P 30 CA46592NCI NIH HHSUnited StatesP30CA046592PubMed and NIHNIH RePORTER
CA101860NCI NIH HHSUnited StatesR01CA101860PubMed and NIHNIH RePORTER
CA66233NCI NIH HHSUnited StatesPubMedPubMed

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References38

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
110,557,086Involvement of Notch1 in the development of mouse mammary tumors.Oncogene1999https://conductscience.org/library/papers/10557086PubMed
210,528,225Arbiter of differentiation and death: Notch signaling meets apoptosis.J Cell Physiol1999https://conductscience.org/library/papers/10528225PubMed
310,645,000Identification of a novel NOTCH-4/INT-3 RNA species encoding an activated gene product in certain human tumor cell lines.Oncogene2000https://conductscience.org/library/papers/10645000PubMed
410,797,286Expression of an activated Notch4(int-3) oncoprotein disrupts morphogenesis and induces an invasive phenotype in mammary epithelial cells in vitro.Int J Cancer2000https://conductscience.org/library/papers/10797286PubMed
510,837,027Notch signaling is essential for vascular morphogenesis in mice.Genes Dev2000https://conductscience.org/library/papers/10837027PubMed
610,850,492Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.Cell2000https://conductscience.org/library/papers/10850492PubMed
710,882,062A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1.Mol Cell2000https://conductscience.org/library/papers/10882062PubMed
810,980,592Ras pathway signals are required for notch-mediated oncogenesis.Oncogene2000https://conductscience.org/library/papers/10980592PubMed
911,010,805Notch signaling: a dance of proteins changing partners.Exp Cell Res2000https://conductscience.org/library/papers/11010805PubMed
1011,182,080Notch1 and Notch3 instructively restrict bFGF-responsive multipotent neural progenitor cells to an astroglial fate.Neuron2001https://conductscience.org/library/papers/11182080PubMed

1 to 10 of 38

See all 38 references

Cited by379

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 581 citations.

PMIDTitleJournalYearIn PapersSource
42,974,381Astrocyte plasticity shapes brain metastasis progression through tumor-astrocyte crosstalk.Cancer Heterog Plast2025https://conductscience.org/library/papers/42974381PubMed
42,426,902Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications.J Hematol Oncol2026https://conductscience.org/library/papers/42426902PubMed
41,206,509The Glyco-Switch of life: O-GlcNAcylation in cell fate decision.Glycobiology2025https://conductscience.org/library/papers/41206509PubMed
41,027,955Role of Notch gene receptors as prognostic biomarkers in colorectal cancer.Sci Rep2025https://conductscience.org/library/papers/41027955PubMed
40,733,561The Gene Expression Profile of Milk Somatic Cells of Small Ruminant Lentivirus-Seropositive and -Seronegative Dairy Goats (Capra hircus) During Their First Lactation.Viruses2025https://conductscience.org/library/papers/40733561PubMed
40,080,721Signaling pathway dysregulation in breast cancer.Oncotarget2025https://conductscience.org/library/papers/40080721PubMed
40,006,075Drug Treatment Direction Based on the Molecular Mechanism of Breast Cancer Brain Metastasis.Pharmaceuticals (Basel)2025https://conductscience.org/library/papers/40006075PubMed
40,003,637Notch and Hedgehog Signaling Unveiled: Crosstalk, Roles, and Breakthroughs in Cancer Stem Cell Research.Life (Basel)2025https://conductscience.org/library/papers/40003637PubMed
39,940,912Mutanobactin-D, a Streptococcus mutans Non-Ribosomal Cyclic Lipopeptide, Induces Osteogenic/Odontogenic Differentiation of Human Dental Pulp Stem Cells and Human Bone Marrow Stem Cells.Int J Mol Sci2025https://conductscience.org/library/papers/39940912PubMed
39,853,518Targeting breast cancer stem cells in ER-positive breast cancer by repurposing the benzoporphyrin derivative verteporfin as a YAP/TAZ small molecule inhibitor.Mol Biol Rep2025https://conductscience.org/library/papers/39853518PubMed

1 to 10 of 379

See all 379 cited by

Genes9

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
DLK18,788PubTator's text mininghttps://conductscience.org/library/genes/8788NCBI Gene
EPCAM4,072PubTator's text mininghttps://conductscience.org/library/genes/4072NCBI Gene
HES13,280PubTator's text mininghttps://conductscience.org/library/genes/3280NCBI Gene
KRT143,861PubTator's text mininghttps://conductscience.org/library/genes/3861NCBI Gene
KRT183,875PubTator's text mininghttps://conductscience.org/library/genes/3875NCBI Gene
MME4,311PubTator's text mininghttps://conductscience.org/library/genes/4311NCBI Gene
MUC14,582PubTator's text mininghttps://conductscience.org/library/genes/4582NCBI Gene
NOTCH14,851PubTator's text mininghttps://conductscience.org/library/genes/4851NCBI Gene
NOTCH44,855PubTator's text mininghttps://conductscience.org/library/genes/4855NCBI Gene

Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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