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Paper · 20148675

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.

Huang P and 2 others. Annu Rev Physiol, 2010. Cited by 379 papers, by iCite.

11 sourcespapers-2026-11-12-0.1.0

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ConductScience Library. Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. Papers, record 20148675. Release papers-2026-11-12-0.1.0, 12 Nov 2026. https://conductscience.org/library/papers/20148675

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Paper

PubMed's record of the paper, with iCite's citation figures. No abstract is shown.

Title
Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.
PubMed
Journal
Annu Rev Physiol
PubMed
Year
2010
PubMed
Publication types
Journal Article, Review
PubMed
Citations, by iCite
379
iCite
Relative citation ratio, by iCite
9.31
iCite
Revised in PubMed
2022-03-17
PubMed

Authors3

The authors in the order PubMed's record lists them, with the ORCID iDs it states.

OrderAuthorForenameKindORCID iD
1Huang PPengxiang
2Chandra VVikas
3Rastinejad FFraydoon

Source PubMed

Topics12

NLM's MeSH indexing of the paper, its major topics first.

MeSH termMajor
Drug DiscoveryMajor topic
Drug TherapyMajor topic
Nuclear ProteinsMajor topic
Receptors, Cytoplasmic and NuclearMajor topic
Amino Acid Sequence
Animals
Humans
Lipid Metabolism
Protein Structure, Secondary
Receptors, Estrogen
Receptors, Steroid
Receptors, Thyroid Hormone

Source PubMed

Grants2

Each grant PubMed's record writes, matched to the NIH project NIH's grant and paper links name for this paper, and each of those links the record does not write.

Grant, as the record writes itAgencyCountryNIH projectStated bySource
P30 DK067629NIDDK NIH HHSUnited StatesP30DK067629PubMed and NIHNIH RePORTER
R01 GM055217NIGMS NIH HHSUnited StatesR01GM055217PubMed and NIHNIH RePORTER

Trials0

The trials whose ClinicalTrials.gov record lists the paper, and the trial numbers the paper's PubMed record names.

None in this release.

Comments and corrections0

PubMed's comments and corrections, NLM's own indexing: retractions first, then expressions of concern, errata and updates, and comments last.

None in this release.

References167

The papers the reference list in PubMed's record names, those in our copy of PubMed, in the list's order.

OrderPMIDTitleJournalYearIn PapersSource
116,137,620Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking.Mol Cell2005https://conductscience.org/library/papers/16137620PubMed
29,600,906Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.Proc Natl Acad Sci U S A1998https://conductscience.org/library/papers/9600906PubMed
318,812,595Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia.J Lipid Res2009https://conductscience.org/library/papers/18812595PubMed
410,696,570How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.Endocr Rev2000https://conductscience.org/library/papers/10696570PubMed
511,179,889Retinoid X receptor and its partners in the nuclear receptor family.Curr Opin Struct Biol2001https://conductscience.org/library/papers/11179889PubMed
617,978,568PPARgamma physiology and pathology in gastrointestinal epithelial cells.Mol Cells2007https://conductscience.org/library/papers/17978568PubMed
719,043,829Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.Nature2008https://conductscience.org/library/papers/19043829PubMed
815,456,246Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.J Med Chem2004https://conductscience.org/library/papers/15456246PubMed
919,337,272Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes.Nat Rev Drug Discov2009https://conductscience.org/library/papers/19337272PubMed
1010,373,553Distinct glucocorticoid receptor transcriptional regulatory surfaces mediate the cytotoxic and cytostatic effects of glucocorticoids.Mol Cell Biol1999https://conductscience.org/library/papers/10373553PubMed

1 to 10 of 167

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Cited by195

The papers in our copy of PubMed whose reference list names this one, newest first. iCite, which reads more sources, counts 379 citations.

PMIDTitleJournalYearIn PapersSource
42,422,020PROTAC-mediated regulation of programmed cell death: From molecular mechanisms to therapeutic breakthroughs.Innovation (Camb)2026https://conductscience.org/library/papers/42422020PubMed
41,924,275New p65 iso5 isoforms as dexamethasone-binding proteins: novel potential therapeutic targets for inflammatory diseases.Front Immunol2026https://conductscience.org/library/papers/41924275PubMed
41,750,342Nuclear Receptor-Targeted Therapies: Reprogramming Metabolism with TRβ, ERRα, and LXR Modulators.Biomolecules2026https://conductscience.org/library/papers/41750342PubMed
41,571,652Antibody-conjugated mesenchymal stromal cell drug delivery system for the treatment of autoimmune diseases in mice.Nat Commun2026https://conductscience.org/library/papers/41571652PubMed
41,543,151Role of tumor‑infiltrating lymphocytes and miR‑155 in breast cancer: Insights into carcinogenesis and their potential as prognostic biomarkers (Review).Oncol Rep2026https://conductscience.org/library/papers/41543151PubMed
40,885,723Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse.Oncogenesis2025https://conductscience.org/library/papers/40885723PubMed
40,231,860Small Molecules Targeting the Structural Dynamics of AR-V7 Partially Disordered Proteins Using Deep Ensemble Docking.J Chem Theory Comput2025https://conductscience.org/library/papers/40231860PubMed
40,082,595Structural basis for the asymmetric binding of coactivator SRC1 to FXR-RXRα and allosteric communication within the complex.Commun Biol2025https://conductscience.org/library/papers/40082595PubMed
39,900,897Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex.Nat Commun2025https://conductscience.org/library/papers/39900897PubMed
39,770,128In Silico Design of Dual Estrogen Receptor and Hsp90 Inhibitors for ER-Positive Breast Cancer Through a Mixed Ligand/Structure-Based Approach.Molecules2024https://conductscience.org/library/papers/39770128PubMed

1 to 10 of 195

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Genes35

The genes the Gene search release ties to the paper: Swiss-Prot's references first, then PubTator's text mining.

GeneNCBI Gene IDLinked byIn GenesSource
AR367PubTator's text mininghttps://conductscience.org/library/genes/367NCBI Gene
ESR12,099PubTator's text mininghttps://conductscience.org/library/genes/2099NCBI Gene
ESR22,100PubTator's text mininghttps://conductscience.org/library/genes/2100NCBI Gene
ESRRG2,104PubTator's text mininghttps://conductscience.org/library/genes/2104NCBI Gene
F2R2,149PubTator's text mininghttps://conductscience.org/library/genes/2149NCBI Gene
GRIP123,426PubTator's text mininghttps://conductscience.org/library/genes/23426NCBI Gene
HNF4A3,172PubTator's text mininghttps://conductscience.org/library/genes/3172NCBI Gene
HSD11B23,291PubTator's text mininghttps://conductscience.org/library/genes/3291NCBI Gene
INS3,630PubTator's text mininghttps://conductscience.org/library/genes/3630NCBI Gene
JUNB3,726PubTator's text mininghttps://conductscience.org/library/genes/3726NCBI Gene

1 to 10 of 35

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Drugs0

The drugs whose trials, in the Pipelines release, list the paper.

None in this release.

Data0

The data bank entries PubMed's record names. Trial numbers are under Trials.

None in this release.

Data dates

The date of each source this release read.

PubMed
2026-11-06
PubMed
iCite
2026-11-05
iCite
PMC's ID file
2026-11-05
PMC's ID file
NIH RePORTER's grant and paper links
2026-11-01
NIH RePORTER's grant and paper links
Trials
2026-11-12
Gene search
2026-11-11
Pipelines
2026-09-18

Sources 11

  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • HGNCCC0
  • iCiteCC BY 4.0
  • NCBI GenePublic domain (US government)
  • NIH RePORTER's grant and paper linksPublic domain
  • Open TargetsCC0 1.0
  • PMC's ID filePublic domain (US government)
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • HGNCCC0: https://www.genenames.org/about/license/
  • iCiteCC BY 4.0
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH RePORTER's grant and paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PMC's ID fileNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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